A5002608068- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Medical Imaging and Pathology Studies
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Legionella and Acanthamoeba research
- Influenza Virus Research Studies
- Infectious Diseases and Mycology
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Bacterial biofilms and quorum sensing
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Gastrointestinal disorders and treatments
- Eosinophilic Disorders and Syndromes
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Diagnosis and treatment of tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
Osaka University
2016-2025
University of the Ryukyus University Hospital
2014-2025
University of the Ryukyus
2015-2024
Dai-ichi Life Insurance (United States)
2023-2024
Naha City Hospital
2023
Weatherford College
2020-2022
Osaka University Hospital
2019-2021
Aichi Medical University Hospital
2020
Okayama University
1998-2018
Creative Research Enterprises (United States)
2018
Analysis of microbiota in various biological and environmental samples under a variety conditions has recently become more practical due to remarkable advances next-generation sequencing. Changes leading specific states including some the complex diseases can now be characterized with relative ease. It is known that gut involved pathogenesis inflammatory bowel disease (IBD), mainly Crohn's ulcerative colitis, exhibiting symptoms gastrointestinal tract. Recent studies also showed increased...
Legionella pneumophila is the causative agent of human Legionnaire's disease. During infection, bacterium invades macrophages and lung epithelial cells, replicates intracellularly. However, little known about its interaction with T cells. We investigated ability L. to infect stimulate production interleukin-8 (IL-8) in The objective this study was assess whether interferes immune system by interacting infecting cells.Wild-type flagellin-deficient Legionella, but not lacking a functional type...
As the histogenesis and development of α-fetoprotein-producing gastric cancer (AFPGC) have not yet been elucidated, we analyzed histologic immunologic relationship between type mucosal lesion considered to be primary lesion, that its invasive in 36 cases AFPGC.We reviewed 23 AFPGCs with lesions (1 22 submucosal or deeper tumors) among had resected endoscopically surgically 1970 2005. AFPGC was defined as a tumor showing immunohistochemical positivity for either α-fetoprotein (AFP)...
The prevalence of nontuberculous mycobacteria (NTM) pulmonary diseases has been increasing worldwide. NTM consist approximately 200 species and distinguishing between them at the subspecies level is critical to treatment. In this study, we sequenced 63 genomes, 27 which were newly determined, by hybrid assembly using sequencers from Illumina Oxford Nanopore Technologies (ONT). This analysis expanded available genomic data 175 redefined their subgenus classification. We also developed a novel...
While respiratory virus infection has been implicated in the onset of bacterial pneumonia, no research investigated association viruses with aspiration pneumonia (AP). This study aimed to investigate role infections AP. Patients presenting acute symptoms and undergoing influenza antigen testing at emergency department Okinawa Chubu Hospital from February 2020 January 2021, diagnosed lower tract infections, were included. Cases categorized into AP, other than AP (non-AP), bronchitis (AB)...
The pathological features of lung disease in nine patients with systemic sclerosis (SSc) were evaluated. comprised one man and eight women, a median age 58 years. SSc was diagnosed according to the criteria American Rheumatism Association. In all patients, high resolution computed radiographic scanning lungs (HRCT) performed, apparent honeycomb formation seen four patients. Pathologically, usual interstitial pneumonia (UIP), three non-specific (NSIP) group II, NSIP II–III, II diffuse...
The present study was designed to evaluate the pathological and immunohistochemical findings of Mycobacterium avium intracellulare complex (MAC) lung infection. A retrospective performed in five cases with positive cultures for MAC whom resections were between January 1989 December 1996. determination whether or not caused pulmonary disease made using 1997 criteria defined by American Thoracic Society. In addition, cultured from all specimens. Pathological as well chest computed tomography...
A large-scale study was undertaken to clarify the prevalence rate of strongyloidiasis in Okinawa, Japan and evaluate relationship between infection with human T cell lymphotropic virus type 1 (HTLV-1). The Strongyloides stercoralis HTLV-1 were 6.3% 14.0%, respectively. Among 2,185 patients more than 50 years age, S. significantly higher compared without infection. In 252 treated ivermectin, serum IgE levels peripheral eosinophil counts lower co-infected addition, anthelmintic effect Our...
On the basis of “protease-antiprotease imbalance” theory for pathogenesis pulmonary emphysema, we hypothesized that measurement elastase burden and antielastase capacity in alveolar space might correlate with emphysema. To evaluate this, severity burden, inhibitory were estimated 28 patients chronic bronchitis variable degrees none whom had congenital deficiency alpha-1-protease inhibitor, all underwent bronchoalveolar lavage. Emphysema was assessed by both computed tomography diffusing...
Abstract The mechanism of host cell recognition Cryptococcus neoformans, an opportunistic fungal pathogen in immunocompromised patients, remains poorly understood. In the present study, we asked whether DNA this yeast activates mouse bone marrow-derived myeloid dendritic cells (BM-DCs). BM-DCs released IL-12p40 and expressed CD40 upon stimulation with cryptococcal DNA, response was abolished by treatment DNase, but not RNase. production expression were attenuated chloroquine, bafilomycin A,...
Abstract Dectin‐1 is known as a sole receptor for β‐glucan, major cell wall component of fungal microorganisms. In the current study, we examined role this molecule in host defense to Cryptococcus neoformans , an opportunistic pathogen AIDS patients. There was no significant difference clinical course and cytokine production between dectin‐1 gene‐deficient control mice. These results indicate that not likely essential development protective responses C. .
Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand phylogenetic relationships among S. stercoralis isolates infecting humans to assess zoonotic potential this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S a sperm protein domain-containing genes. Overall, our analyses indicated presence distinct lineages (referred as type A B). While parasites were isolated both from in different countries, B found...
Recent reports indicate that respiratory infectious diseases were suppressed during the novel coronavirus disease-2019 (COVID-19) pandemic. COVID-19 led to behavioral changes aimed control droplet transmission or contact transmission. In this study, we examined incidence of common in Japan data extracted from national based on National Epidemiological Surveillance Infectious Diseases (NESID). Common selected notifiable under NESID. The epidemic activity 2015-2020 was evaluated Disease Weekly...
The beneficial effect of short-term smoking reduction in reducing lower respiratory tract inflammation was assessed 15 healthy heavy smokers. All underwent fibreoptic bronchoscopy and bronchoalveolar lavage were then treated with at least 20 mg nicotine gum daily. Self-reported cigarette consumption decreased from 50.7 +/- 2.3 to 18.8 1.5 (p less than 0.001) cigarettes daily, expired CO 48.5 2.5 27.3 ppm 0.001). After two months, repeat revealed that bronchial inflammation, as by direct...
The present study was designed to elucidate the role of Toll-like receptor (TLR) 2 and TLR4 in host response Cryptococcus neoformans. Both TLR2 knockout (KO) TLR4KO mice produced interleukin-1beta (IL-1beta), IL-6, IL-12p40 tumor necrosis factor-alpha (TNF-alpha) sera cleared this fungal pathogen from infected lungs at a comparable level control littermate (LM) mice. Synthesis these cytokines not significantly different KO LM mice, although IL-1beta, IL-6 tended be lower TLR2KO, but TLR4KO,...
New serum markers (1-->3) beta-D-glucan (beta-D-glucan) and KL-6 are reported to be useful for the clinical diagnosis of Pneumocystis jirovecii pneumonia (PCP). However, utility these in PCP with HIV infection (HIV PCP) without (non-HIV is unknown. This study was aimed evaluate patients non-HIV PCP.Retrospective study.We reviewed medical records consecutive 35 patients. The levels were comparatively evaluated. We evaluated survivors non survivors.The detection rates lower than those (88% vs....
In Japan, the clinical characteristics and recent serotype distribution among adult patients of invasive pneumococcal disease (IPD) have not been fully investigated since introduction conjugate vaccine (PCV) in children. From November 2010, PCV7 was encouraged by an official program, funded government, subsequently included routine schedule April 2013, replaced with a PCV13 2013. Between 2013 March 2015, IPD older than 15 years were evaluated based on enhanced national surveillance ten...
Summary The human gut harbours diverse microorganisms, and dysbiosis has recently attracted attention because of its possible involvement in various diseases. In particular, the lack diversity microbiota been associated with complications haematopoietic stem cell transplantation (HSCT), such as infections, acute graft‐versus‐host disease relapse primary disease, which lead to a poor prognosis. However, few studies have serially examined composition intestinal after HSCT. this study, we...