A5001211200- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Cancer-related gene regulation
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
National Cancer Center Hospital East
2012-2025
Tokyo National Hospital
2016-2025
Keio University
2024-2025
National Hospital Organization
2011-2024
National Defense Medical College
2024
Iwate Medical University
2023-2024
The Japanese Society of Gastroenterological Surgery
2023-2024
Onomichi General Hospital
2023-2024
Hiroshima University
2023-2024
Kure Medical Center
2024
Cellular plasticity in adult organs is involved both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reactivation of pathways embryonic pancreatic development. In contrast, such promotes the development ductal adenocarcinoma (PDA) precursor lesions mice expressing constitutively active form GTPase, Kras, exocrine pancreas. The molecular environment mediates versus PDA poorly...
Next-generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide management by providing information about actionable gene aberrations that have diagnostic and therapeutic significance. Here, we undertook a hospital-based prospective study (TOP-GEAR project, 2nd stage) to investigate the feasibility utility NGS-based analysis 114 cancer-associated genes (the NCC Oncopanel test). We examined 230 cases (comprising more than 30 types) advanced solid tumors, all which were...
Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in tumorigenesis poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 YAP1-NUTM1 poromas (92/104 lesions, 88.5%) their rare malignant counterpart, porocarcinomas (7/11 63.6%). A WWTR1-NUTM1 fusion was single lesion poroma. Fluorescence situ hybridization confirmed genomic rearrangements involving...
Abstract Hereditary colorectal cancer (HCRC) accounts for < 5% of all cases. Some the unique characteristics commonly encountered in HCRC cases include early age onset, synchronous/metachronous occurrence, and multiple cancers other organs. These necessitate different management approaches, including diagnosis, treatment or surveillance, from sporadic management. There are two representative HCRC, named familial adenomatous polyposis Lynch syndrome. Other than these syndromes, related...
Pancreatic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in the United States. Deregulation of Hedgehog signaling has been implicated pathogenesis PDA. To gain insights into role pathway during distinct stages pancreatic carcinogenesis, we established mouse model which is activated specifically epithelium. Transgenic mice survived to adulthood and developed undifferentiated carcinoma, indicating epithelium-specific sufficient drive neoplasia...
There is accumulating evidence that Wnt/β-catenin signaling involved in the regulation of liver development and physiology. The presence genetic alterations resulting constitutive β-catenin stabilization human murine tumors also implicates this pathway hepatocyte proliferation. In present study, we generated hepatocyte-specific knockout mice to explore role function. Conditional were born at expected Mendelian ratio developed normally adulthood, indicating dispensable for essential function...
Ewing sarcoma is a high-grade round cell that affects bones and soft tissues in children young adults. Its diagnosis can be challenging, the differential diagnoses include wide variety of small tumors. CD99 FLI-1 are currently accepted immunohistochemical markers for sarcoma, but their accuracy has been controversial. NKX2.2 homeodomain-containing transcription factor plays critical role neuroendocrine/glial differentiation. The gene was recently identified as target EWS-FLI-1, fusion...
The molecular basis for the development of appendiceal mucinous tumours, which can be a cause pseudomyxoma peritonei, remains largely unknown. Thirty-five neoplasms were analysed GNAS and KRAS mutations. A functional analysis mutant was performed using colorectal cancer cell line. mutational identified activating mutations in 16 32 low-grade (LAMNs) but none three adenocarcinomas (MACs). found 30 LAMNs all MACs. We additionally total 186 extra-appendiceal tumours that highly prevalent...
Recent studies have suggested that β-catenin is involved in the regulation of hepatocyte proliferation multiple contexts, including organ development and tumorigenesis. We explored role during liver regeneration using T cell factor/lymphoid enhancer factor (TCF/LEF)-reporter mice (TOPGal mice) liver-specific knockout mice. Liver-specific showed a delayed onset DNA synthesis after hepatectomy, whereas recovery mass was not affected. Among putative target genes examined, induction Ccnd1...
<b>Background and study aims: </b>As more early gastric cancer (EGC) patients are being treated with endoscopic submucosal dissection (ESD), it is important to understand the outcomes of who develop metachronous (MGC). The aim this was evaluate long-term surveillance treatment MGC after curative ESD. <b>Patients methods: </b>The included 1526 consecutive underwent ESD resection EGC. They were generally followed by annual or biannual esophagogastroduodenoscopy. risk factors for assessed along...
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 polyps, including hyperplastic sessile adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous by using targeted next-generation sequencing reverse transcription-PCR. Our analyses showed that most TSAs (71%) contained WNT components. particular,...
As the histogenesis and development of α-fetoprotein-producing gastric cancer (AFPGC) have not yet been elucidated, we analyzed histologic immunologic relationship between type mucosal lesion considered to be primary lesion, that its invasive in 36 cases AFPGC.We reviewed 23 AFPGCs with lesions (1 22 submucosal or deeper tumors) among had resected endoscopically surgically 1970 2005. AFPGC was defined as a tumor showing immunohistochemical positivity for either α-fetoprotein (AFP)...
Gastric and duodenal adenomas exhibit a significant morphological phenotypical diversity are classified into intestinal-type, foveolar-type pyloric gland adenomas. We analysed the mutations in GNAS, KRAS, BRAF CTNNB1 expressions of mismatch repair (MMR) proteins 80 gastric 32 with histologically distinct subtypes, as well 71 adenocarcinomas. Activating GNAS were found 22 35 (PGAs; 63%) but none or intestinal-type Fourteen PGAs (41%), two (9%), five (9%) one adenocarcinoma (1%) had KRAS...
Although recent findings of cancer biology research indicate that prognostic power arises from genes expressed by stromal cells rather than epithelial cells, desmoplastic reaction (DR) has not been completely examined as a marker for colorectal cancer. A pathologic review 821 stage II and III patients who underwent R0 resection at 4 independent institutions was conducted. DR classified mature, intermediate, or immature based on the existence hyalinized keloid-like collagen myxoid stroma...
Neuroendocrine carcinoma (NEC) of the stomach has been recognized as a highly malignant tumor; however, because its rarity, limited information is available regarding clinicopathologic characteristics. Here, we investigated morphologic and immunohistochemical features prognosis 51 cases gastric NEC. Histologically, 40 lesions were large cell type, 11 small type. The majority tumors exhibited solid growth pattern (94%), with subsets showing trabecular (18%), scirrhous (10%), or tubular...
Phyllodes tumours are rare fibroepithelial of the breast, that include benign, borderline, and malignant lesions. Although molecular basis phyllodes largely remains unknown, a recent exome study identified MED12 mutations as sole recurrent genetic alteration in fibroadenoma, common benign tumour shares some histological features with tumour. Forty-six 58 fibroadenomas breast were analysed for by using Sanger sequencing. 37 out 46 (80%). The prevalence was similar among (15/18, 83%),...
Background and study aim Endoscopic submucosal dissection (ESD) is known as a curative treatment for colorectal superficial neoplasms. There however need more long-term clinical data to establish the full advantages of ESD regarding very low recurrence rates. The this retrospective was determine outcomes ESD. Methods A total 423 lesions treated by adenoma/dysplasia or adenocarcinoma between 1998 2008 at single high volume referral center were included. We conducted survey on patients with...
Background Magnifying Narrow Band Imaging (NBI) during colonoscopy is a reliable method for differential and depth diagnoses of colorectal lesions. This study examined the diagnostic yield magnifying NBI based on Japan Expert Team (JNET) classification in clinical setting using large‐scale practice database. Types 1, 2A, 2B 3 correspond to histopathological classifications hyperplastic polyp/sessile‐serrated polyp, low‐grade intramucosal neoplasia, high‐grade neoplasia/shallow submucosal...