A5051611223- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- 14-3-3 protein interactions
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
University of Tsukuba
2015-2025
Okayama Prefecture
2023-2025
Suita Tokushukai Hospital
2022-2025
John Wiley & Sons (Germany)
2024
Shonan Kamakura General Hospital
2022-2024
Shonan Institute of Technology
2023-2024
Okayama Psychiatric Medical Center
2012-2022
Saba University School of Medicine
2020
University of Tsukuba Hospital
1985-2019
Planetary Science Institute
2018
The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R was demonstrated to be a the IL-4 on basis chemical cross-linking data, ability augment binding affinity, requirement for in IL-4-mediated phosphorylation insulin substrate-1. observation that functional receptor, together with finding associates IL-7 begins elucidate why deficiency this common (gamma c) has profound effect lymphoid function...
Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor γ chain (γ c ) gene that encodes a shared, essential component of receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15. The Janus family tyrosine kinase Jak3 is only signaling molecule known to be associated , so it was hypothesized might cause an XSCID-like phenotype. A girl immunological features indistinguishable from those XSCID therefore selected analysis. An Epstein-Barr...
Interleukin-2 (IL-2) signaling requires the dimerization of IL-2 receptor β (IL-2Rβ) and common γ (γ c ) chains. Mutations can result in X-linked severe combined immunodeficiency (XSCID). IL-2, IL-4, IL-7 (whose receptors are known to contain ), IL-9 is shown here induced tyrosine phosphorylation activation Janus family kinases Jak1 Jak3. Jak3 associated with IL-2Rβ , respectively; Jak3-IL-2Rβ increased Jak3-γ associations. Truncations a point mutation causing moderate (XCID), decreased...
The interleukin-2 (IL-2) receptor γ chain (IL-2Rγ) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2Rγ was demonstrated to be a the IL-4 on basis chemical cross-linking data, ability augment binding affinity, requirement for in IL-4-mediated phosphorylation insulin substrate-1. observation that functional receptor, together with finding associates IL-7 begins elucidate why deficiency this common (gamma; c ) has profound effect lymphoid function development, as...
Neuroendocrine (NE) tumors of the lung include typical carcinoid (TC), atypical (AC), large-cell NE carcinoma (LCNEC), and small-cell (SCLC). Their clinicopathologic profiles relative grade malignancy have not been defined.From 10 Japanese institutes, 383 surgically resected pulmonary were collected. The histologic diagnosis was determined by consensus a pathology panel consisting six expert pathologists as TC, AC, LCNEC, or SCLC on basis WHO classification, its relationship to analyzed.Of...
The new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification provides, first time, standardized terminology cancer diagnosis in small biopsies and cytology; this was not primarily addressed by previous World Health Organization classifications. Until recently there have been no therapeutic implications to further NSCLC, so little attention has given distinction squamous cell carcinoma tissue samples....
Review of 61 surgically resected small hepatocellular carcinomas (HCC) less than or equal to 3 cm in diameter yielded a simple gross classification system five types based on tumor shape, which is highly correlated with microscopic and clinical features, including prognosis. Type 1 (single nodular type) tumors (n = 13) are expansile, roughly spheric, often encapsulated. In 2 type extranodular growth) 21), replacing growth seen the area growth. (contiguous multinodular 19) consist nodules...