A5035341894- Advanced Optical Imaging Technologies
- Interactive and Immersive Displays
- Virus-based gene therapy research
- Augmented Reality Applications
- Lung Cancer Diagnosis and Treatment
- Virtual Reality Applications and Impacts
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Vision and Imaging
- Medical Imaging and Pathology Studies
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Tactile and Sensory Interactions
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- CAR-T cell therapy research
- Optical measurement and interference techniques
- Advanced Drug Delivery Systems
- Robotics and Automated Systems
- Medical Imaging Techniques and Applications
- Color Science and Applications
- Advanced Optical Sensing Technologies
- Analytical Chemistry and Chromatography
- Dermatology and Skin Diseases
- Crystallization and Solubility Studies
University of Electro-Communications
2016-2025
Niigata Cancer Center Hospital
2007-2025
Showa Pharmaceutical University
2011-2024
Japan Science and Technology Agency
2020
University of Tsukuba
2015
The University of Tokyo
2003-2015
Keio University
2010-2012
Black AIDS Institute
2009-2012
University of California, Los Angeles
2012
University of Amsterdam
2009
Purpose The image noise and quality of a prototype ultra-high-resolution computed tomography (U-HRCT) scanner was evaluated compared with those conventional high-resolution CT (C-HRCT) scanners. Materials Methods This study approved by the institutional review board. A U-HRCT 0.25 mm x 4 rows operating at 120 mAs used. C-HRCT images were obtained using 0.5 16 or 64 detector-row 150 mAs. Images from both scanners reconstructed 0.1-mm intervals; slice thickness for For scanners, display field...
Claudin, a tight junction integral membrane protein and family of proteins, forms the actual sealing element junction. There are more than 20 members claudin with different tissue-specific expression barrier functions. Thus, may be target for modifying absorption drugs. Here, we examined whether modulation could used to enhance drug absorption. In current studies, C-terminal fragment <i>Clostridium perfringens</i> enterotoxin (C-CPE) as modulator claudin-4. The dextran was assessed in an...
A normalized least-mean-squares (NLMS) adaptive algorithm with double the convergence speed, at same computational load, of conventional NLMS for an acoustic echo canceller is proposed. This algorithm, called ES (exponentially weighted stepsize) uses a different stepsize (feedback constant) each weight transversal filter. These stepsizes are time-invariant and proportionally to expected variation room impulse response. The adjusts coefficients large errors in steps, small steps. transition...
We focus on the dining and show how to improve experience. use sound effects augment food texture, creating a cross-modal illusion.
Abstract Background Fiber‐modified adenovirus (Ad) vectors can be effective in overcoming the limitations of conventional Ad vectors, specifically their inefficient gene transfer into cells lacking primary receptor, coxsackievirus and receptor (CAR). Several types fiber‐modified have been developed. In this study, we evaluated functionality several vectors. Methods We developed a simple method based on vitro ligation to construct containing heterologous foreign peptides both HI loop C...
ABSTRACT The primary receptor, the coxsackievirus and adenovirus receptor (CAR), secondary αv integrins, are tropism determinants of (Ad) type 5. Inhibition interaction both fiber with CAR penton base integrin appears to be crucial development targeted Ad vectors, which specifically transduce a given cell population. In this study, we developed vectors ablation binding by mutating knob RGD motif base. We also replaced shaft domain that derived from 35. High transduction efficiency in mouse...
A replication-incompetent adenoviral (Ad) vector is generating interest for both gene therapy and immunotherapy. major limitation of the use Ad vectors innate immune response, which causes inflammatory cytokine production tissue damage; however, precise mechanism response remains to be clarified. Here, we show that serotype 5 human elicit responses through a myeloid differentiating factor 88 (MyD88)/Toll-like receptor (TLR)-9-dependent and/or -independent manner according cell type. After...
Abstract Adenovirus (Ad) vectors are one of the most commonly used viral in gene therapy clinical trials. However, they elicit a robust innate immune response and inflammatory responses. Improvement therapeutic index Ad vector requires elucidation mechanism vector-induced inflammation cytokine/chemokine production as well development safer vector. In present study, we found that fiber-modified containing poly-lysine peptides fiber knob showed much lower serum IL-6 aspartate aminotransferase...
Coxsackievirus and adenovirus receptor (CAR), αv integrins, heparan sulfate glycosaminoglycans (HSGs) are the tropism determinants of adenoviral (Ad) vectors in vivo. For development a targeted Ad vector, its broad needs to be blocked (or reduced). We have previously developed with ablation CAR, integrin, HSG binding by mutation FG loop fiber knob (deletion T489, A490, Y491, T492 protein), deletion RGD motif penton base, substitution shaft domain for that derived from type 35, respectively,...
BackgroundMeasuring the size of invasiveness on computed tomography (CT) for T descriptor was deemed important in 8th edition TNM lung cancer classification. We aimed to correlate maximal dimensions solid portions using both and mediastinal window settings CT imaging with pathologic (> 0.5 cm) adenocarcinoma patients.Materials MethodsThe study population consisted 378 patients a histologic diagnosis situ (AIS), minimally invasive (MIA), (IVA)-lepidic, IVA-acinar and/or IVA-papillary,...
The aim of the present study was to evaluate bioavailability a drug from rapidly disintegrating tablets prepared using fine spherical crystalline cellulose (PH-M-06) and sugar granules (Nonpareil, NP). Rapidly containing acetaminophen as model in combination with mixture NP-108 (purified n-mannitol) PH-M-06 were prepared. Plasma concentration profiles pharmacokinetic parameters rabbits investigated after oral administration tablets. No significant difference Cmax AUC(0-infinity) between...
We propose a novel display method, EnchanTable, that can augment table surface with mid-air images. Users interact visual images displayed on the by using real objects. In our optical design, we place an imaging device behind so light from forms vertically standing image reflected at surface. This design displays right table. The merit of method is only requirement for to have reflective Utilizing this, any devices, such as touch sensors, around table, or tablet whose sufficiently...