A5074064898- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Eosinophilic Disorders and Syndromes
- IgG4-Related and Inflammatory Diseases
- Pancreatic and Hepatic Oncology Research
- T-cell and Retrovirus Studies
- Chronic Myeloid Leukemia Treatments
- Cutaneous lymphoproliferative disorders research
- Parvovirus B19 Infection Studies
- Histiocytic Disorders and Treatments
- Neuroblastoma Research and Treatments
- Head and Neck Cancer Studies
- Genetic factors in colorectal cancer
- Ear and Head Tumors
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
Tokai University
2016-2025
John Wiley & Sons (Germany)
2024
Tokai University Hospital
2012-2023
National Hospital Organization
2021
Tsuchiura Kyodo General Hospital
2018
Kurume University
2017
Toranomon Hospital
2017
Fukushima Medical University
1999-2016
Okayama University
2005-2016
Chi Mei Medical Center
2016
We have recently reported EBV+ B-cell lymphoproliferative disorders (LPD) occurring predominantly in elderly patients, which shared features of neoplasms arising the immunologically deteriorated patients despite no predisposing immunodeficiency and were named as senile or age-related LPDs. To further characterize this disease, LPDs compared with EBV-negative diffuse large lymphomas (DLBCL).Among 1,792 LPD cases, 96 cases available clinical data set enrolled for present study. For control...
Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology, and multi-organ dysfunction because pathologic hypercytokinemia. Whereas Human Herpes Virus-8 (HHV-8) drives the hypercytokinemia in cohort immunocompromised patients, etiology HHV-8-negative MCD is idiopathic (iMCD). Recently, limited series iMCD cases Japan sharing constellation clinical features, including thrombocytopenia (T),...
Lymphoid neoplasm with 18q21.3/BCL2 and 8q24/MYC translocation to immunoglobulin (IG) genes as dual-hit lymphoma/leukemia is very rare known have a poor clinical outcome.To clarify the clinicopathological characteristics of this malignancy, we analyzed 27 cases cytogenetically proven lymphoma/leukemia.Dual-hit was diagnosed at presentation in 22 relapse or disease progression 5 cases. At time diagnosis lymphoma/leukemia, extranodal involvement found 25 (93%) central nervous system occurred...
Recently, a unique clinicopathologic variant of multicentric Castleman's disease (MCD) has been identified in Japan. This is characterized by constellation symptoms, as listed the title, and multiple lymphadenopathy mild degree with pathologic diagnosis atypical CD, often posing diagnostic therapeutic problems for pathologists hematologists, respectively. These findings suggest that this represents novel clinical entity belonging to systemic inflammatory disorders background immunological...
Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant lacks GTP binding capacity, suggesting defects the classical signaling. Here, we discovered novel function RHOA: VAV1 was identified as a RHOA-specific partner via high-throughput screening. We that to augmented its adaptor through phosphorylation 174Tyr, resulting acceleration receptor (TCR) Enrichment cytokine and chemokine-related pathways also evident by expression RHOA. further new...
Thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly (TAFRO) syndrome is a heterogeneous entity manifesting with constellation of symptoms described above that can occur in the context idiopathic multicentric Castleman disease (iMCD) as well infectious diseases, malignancies, rheumatologic disorders. So, iMCD-TAFRO an aggressive subtype iMCD TAFRO often hyper-vascularized lymph nodes. Since we proposed diagnostic criteria 2016, have accumulated new...
De novo CD5-positive diffuse large B-cell lymphoma (CD5(+) DLBCL) is clinicopathologically and genetically distinct from CD5-negative (CD5(-)) DLBCL mantle cell lymphoma. The aim of this retrospective study was to clarify the histopathological spectrum obtain new information on therapeutic implications CD5(+) DLBCL.From 1984 2002, 120 patients with were selected 13 collaborating institutes. We analyzed relationship between their morphological features long-term survival. current series...
To clarify the clinicopathologic findings of idiopathic multicentric Castleman disease among Japanese, 28 cases were studied. Two variants delineated by (1) plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia (n = 18) and (2) nonidiopathic type (n= 10). Clinicopathologically, was defined prominent hyperimmunoglobulinemia, normal germinal centers, sheet-like infiltration plasma cells in interfollicular area lymph node. Histologically, characterized hyaline-vascular centers...
TET2 (Ten Eleven Translocation 2) is a dioxygenase that converts methylcytosine (mC) to hydroxymethylcytosine (hmC). loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma harbor follicular helper T (Tfh)-cell-like features, such as angioimmunoblastic (30–83%) or peripheral lymphoma, not otherwise specified (10–49%), well myeloid malignancies. Here, we show middle-aged Tet2 knockdown (Tet2gt/gt) mice exhibit Tfh-like cell overproduction the spleen compared with control...
Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase (IDH2) and ras homolog family member A (RHOA) nodal T-cell lymphomas, including angioimmunoblastic lymphoma peripheral lymphoma, not otherwise specified. We examined the distribution of these subtypes mature T-/natural killer cell neoplasms to determine their clonal architecture. Targeted sequencing was performed for 71 genes...
Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare disease comprising <3% of extranodal lymphomas. It frequently reveals an activated (ABC)-like phenotype. ABC-like DLBCL was reported to have gain-of-function mutations in MYD88, CD79B, CARD11, and TNFAIP3, resulting constitutive activation the NFκB pathway. Because occurrence PB-DLBCL, frequency MYD88 CD79B still unknown. We used Sanger sequencing study these from 46 cases also investigated associated clinicopathologic...
Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells mutations promotes development of T follicular helper (TFH)-like tumor cells. Here, we investigated mechanism which TET2-mutant immune enable AITL using mouse models and human samples. Among 2 models, mice lacking Tet2 all blood (Mx-Cre × Tet2flox/flox transgenic mice) spontaneously developed for approximately up...
Potential sources of cerebellar cortical afferent fibers were identified in the vestibular ganglion, medulla oblongata, pons, and nucleus seven anesthetized Macaca fuscata after local injections wheat germ agglutinin-conjugated horseradish peroxidase or Fast Blue into flocculus (FL) ventral paraflocculus (VP). There differences mossy to FL VP. Labeled neurons, FL, located mainly ipsilateral bilaterally prepositus hypoglossal nuclei, reticularis tegmenti pontis, central part mesencephalic...
Aims: Lymphomatous polyposis (LP) is considered to represent mantle cell lymphoma (MCL) of the gastrointestinal (GI) tract. However, a few reports have suggested that some are follicular (FL) or mucosa‐associated lymphoid tissue (MALT) lymphomas. In this study, we analysed 35 patients and clarified clinicopathological features LP. Methods results: Paraffin‐embedded samples were stained immunohistochemically by tissue‐fluorescence in situ hybridization (T‐FISH) for IGH/CCND1 (cyclin D1)...
Diffuse large B‐cell lymphoma ( DLBCL ) is the most common subtype of malignant lymphoma. The incidence Epstein–Barr virus EBV )‐positive in Asian and Latin American countries ranges from 8 to 10%. prognosis patients with ‐positive controversial. To compare clinical outcome ‐negative rituximab era, we analyzed 239 de novo diagnosed between January 2007 December 2011. presence cells was detected using ‐encoded RNA situ hybridization, it found that 18 (6.9%) 260 tested positive. Among cases,...