Maia Segura‐Wang
A5091582911- Animal Nutrition and Physiology
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Gut microbiota and health
- Fungal and yeast genetics research
- DNA Repair Mechanisms
- Cytomegalovirus and herpesvirus research
- Forensic and Genetic Research
- Lung Cancer Treatments and Mutations
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Childhood Cancer Survivors' Quality of Life
- Mechanisms of cancer metastasis
- Diabetes and associated disorders
- Hedgehog Signaling Pathway Studies
- Genetic Associations and Epidemiology
- Forensic Anthropology and Bioarchaeology Studies
- Genomic variations and chromosomal abnormalities
- Insect-Plant Interactions and Control
- Genetics, Bioinformatics, and Biomedical Research
- Phytoplasmas and Hemiptera pathogens
Medical University of Vienna
2018-2021
Center For Biomarker Research In Medicine
2021
European Molecular Biology Laboratory
2014-2018
Universidad de Costa Rica
2009-2010
Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into biology. Here we present comprehensive analysis of genetic alterations in pan-cancer cohort including 961 tumours from children, adolescents, young adults, comprising 24 distinct molecular cancer. Using standardized workflow, identified marked terms mutation frequency significantly mutated genes comparison previously analysed adult cancers....
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight need molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify full spectrum of driver genes molecular processes that operate in medulloblastoma subgroups. Here we analyse somatic landscape across 491 sequenced samples heterogeneity among 1,256 epigenetically analysed cases, subgroup-specific...
Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma genes have not been defined and screening guidelines for genetic counselling testing paediatric patients are available. We aimed to assess define these provide evidence future guidelines.
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). Largely due to lack suitable model systems, mechanistic basis has remained elusive. We developed an integrative method termed "complex alterations after selection and transformation (CAST)," enabling efficient vitro generation complex including chromothripsis, using cell perturbations...
Increasing evidence shows that the chicken gastrointestinal microbiota has a major effect on modulation of metabolic functions and is correlated with economic parameters, such as feed efficiency health. Some these effects derive from capacity to digest carbohydrates produce energy-rich metabolites short-chain fatty acids (SCFA) host-microbe interactions. In this study, we utilized information metagenomic assembled genomes (MAGs) tract (GIT) samples, detailed annotation carbohydrate-active...
The human virome plays an important role for the clinical outcome of lung transplant recipients (LTRs). While pathogenic viruses may cause severe infections, non-pathogenic serve as potential markers level immunosuppression. However, neither complexity in different compartments nor dynamics virus populations posttransplantation are yet understood. Therefore, this study was analyzed by metagenomic sequencing simultaneously withdrawn bronchoalveolar lavage (BAL) and plasma samples 15 LTRs. In...
Human cytomegalovirus (HCMV) may cause severe infections in lung transplant recipients (LTRs). In response to HCMV infections, a subset of NKG2C+ NK cells expands, which limits replication and is characterized by high expression the activating NKG2C/CD94 absence inhibitory NKG2A/CD94 receptor. Both receptors bind HLA-E, stabilized HCMV-encoded UL40 peptides. HLA-E occur as different genetic variants. this study, we investigated interplay between human cell infecting HCMV-UL40 strain,...
The population of Costa Rica has been considered valuable for locating susceptibility genes complex disorders because historical events and a gradual admixture process. We present an assessment 426 unrelated individuals with familial history mental disorder ancestors born in the Central Valley, genotyped at 730 microsatellites to evaluate genetic diversity, ancestry, substructure general regional levels using quantitative methods. Low was found. Estimated mean ancestry proportions were 54%,...
In recent years, the applicability of prebiotics, probiotics and their mixtures, defined as synbiotics, in poultry production has received considerable attention. Following increasing regulation antibiotic use, these nutraceuticals are seen an alternative way to sustain efficiency resistance pathogens stressors by modulating birds’ gut health. The aim this study was evaluate benefits provided under field conditions administering multi-species synbiotic PoultryStar® sol broilers drinking...
Dermatoglyphic traits have been used to evaluate population structure and microdifferentiation in several populations. For Chibcha-speaking groups of Lower Central America there are few dermatoglyphic studies, but extensive linguistic, anthropological genetic data support their historical, cultural biological relationships. The main objectives this study were describe new for six Chibcha- speaking Amerindians Costa Rica, assess the relationships between these other Amerindian Eskimo groups,...
Deoxynivalenol (DON), a frequent mycotoxin worldwide, impairs human and animal health. The response of microRNAs, small non-coding RNAs, to DON has been scarcely investigated, but holds remarkable potential for biomarker applications. Hence, we aimed investigate DON-induced changes in the microRNA expression porcine liver, jejunum serum by combining targeted untargeted analyses. Piglets received uncontaminated feed or containing 900 µg/kg 2500 four weeks, followed wash-out period. In tissue,...
To ensure genomic integrity, living organisms have evolved diverse molecular processes for sensing and repairing damaged DNA. If improperly repaired, DNA damage can give rise to different types of mutations, an important class which are structural variants (SVs). In spite their importance phenotypic variation genome evolution, potential contributors SV formation in Saccharomyces cerevisiae (budding yeast), a highly tractable model organism, not fully recognized. Here, we developed applied...
In recent years, a rising interest has been directed towards the use of nutraceuticals in zootechnical sector, including probiotics, prebiotics, and synbiotics, as way to support production efficiency cope with increasing limitations antibiotics. poultry, however, most studies on these products have conducted broilers, while less information is available their benefits other productive categories. The present field study aimed assess effects multi-species synbiotic product (PoultryStar® sol)...
Abstract Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. An understanding of regulatory circuitry governing transcriptional landscapes medulloblastoma subgroups, how this relates to their respective developmental origins, currently lacking. Using H3K27ac BRD4 ChIP-Seq, coupled tissue-matched DNA...