A. Sorana Morrissy

ORCID: 0000-0001-8526-562X
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About
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Research Areas
  • Glioma Diagnosis and Treatment
  • Cancer Genomics and Diagnostics
  • Hedgehog Signaling Pathway Studies
  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism
  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • Single-cell and spatial transcriptomics
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • Chromatin Remodeling and Cancer
  • Genetic Syndromes and Imprinting
  • Mitochondrial Function and Pathology
  • Neuroblastoma Research and Treatments
  • CAR-T cell therapy research
  • MicroRNA in disease regulation
  • Cancer Cells and Metastasis
  • Amino Acid Enzymes and Metabolism
  • Cancer-related Molecular Pathways
  • Cell Image Analysis Techniques
  • Circular RNAs in diseases
  • Genomics and Phylogenetic Studies
  • Bioinformatics and Genomic Networks
  • Brain Metastases and Treatment
  • Cancer Immunotherapy and Biomarkers

University of Calgary
2018-2025

Alberta Children's Hospital
2018-2025

Hospital for Sick Children
2014-2025

SickKids Foundation
2012-2025

Institute of Cancer Research
2018-2024

Alberta Children's Hospital Research Institute
2019-2020

Cancer Institute (WIA)
2018

Biologie du Développement et Cellules Souches
2017

University of Toronto
2012-2016

BC Cancer Agency
2009-2014

10.1016/j.ccr.2012.08.024 article EN publisher-specific-oa Cancer Cell 2012-10-01
Florence M.G. Cavalli Marc Remke Ladislav Rampášek John Peacock David Shih and 90 more Betty Luu Livia Garzia Jonathon Torchia Carolina Nör A. Sorana Morrissy Sameer Agnihotri Yuan Thompson Claudia M. Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu‐Chang Wang Ji Yeoun Lee Wiesława Grajkowska Marta Perek‐Polnik Alexandre Vasiljevic Cécile Faure‐Conter Anne Jouvet Caterina Giannini Amulya A. Nageswara Rao Kay Ka Wai Li Ho‐Keung Ng Charles G. Eberhart Ian F. Pollack Ronald L. Hamilton G. Yancey Gillespie James M. Olson Sarah Leary William A. Weiss Bolesław Lach Lola B. Chambless Reid C. Thompson Michael K. Cooper Rajeev Vibhakar Péter Hauser Marie‐Lise C. van Veelen Johan M. Kros Pim J. French Young Seob Shin Toshihiro Kumabe Enrique López‐Aguilar Karel Zitterbart Jaroslav Štěrba Gaetano Finocchiaro Maura Massimino Erwin G. Van Meir Satoru Osuka Tomoko Shofuda Álmos Klekner Massimo Zollo Jeffrey R. Leonard Joshua B. Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy Van Meter Shin Jung Andrew S. Moore Andrew R. Hallahan Jennifer A. Chan Daniela Pretti da Cunha Tirapelli Carlos Gilberto Carlotti Maryam Fouladi José Pimentel Cláudia C. Faria Ali G. Saad Luca Massimi Linda M. Liau Helen Wheeler Hideo Nakamura Samer K. Elbabaa Mario Pérezpeña-Díazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zápotocký Álvaro Lassaletta Annie Huang Cynthia Hawkins Uri Tabori Éric Bouffet Ute Bartels Peter B. Dirks James T. Rutka Gary D. Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D. Taylor

10.1016/j.ccell.2017.05.005 article EN publisher-specific-oa Cancer Cell 2017-06-01

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight need molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify full spectrum of driver genes molecular processes that operate in medulloblastoma subgroups. Here we analyse somatic landscape across 491 sequenced samples heterogeneity among 1,256 epigenetically analysed cases, subgroup-specific...

10.1038/nature22973 article EN cc-by Nature 2017-07-01
Paul A. Northcott David Shih John Peacock Livia Garzia A. Sorana Morrissy and 95 more Thomas Zichner Adrian M. Stütz Andrey Korshunov Jüri Reimand Steven E. Schumacher Rameen Beroukhim David W. Ellison Christian R. Marshall Anath C. Lionel Stephen C. Mack Adrian M. Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M.G. Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Chiu Andy Chu Eric Chuah Richard Corbett Gemma R Hoad Shaun D. Jackman Yisu Li Allan Lo Karen Mungall Ka Ming Nip Jenny Q. Qian Anthony Raymond Nina Thiessen Richard Varhol İnanç Birol Richard A. Moore Andrew J. Mungall Robert A. Holt Daisuke Kawauchi Martine F. Roussel Marcel Kool David Jones Hendrick Witt Africa Fernández-L Anna Marie Kenney Robert J. Wechsler‐Reya Peter B. Dirks Tzvi Aviv Wiesława Grajkowska Marta Perek‐Polnik Christine Haberler Olivier Delattre Stéphanie Reynaud François Doz Sarah S. Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu‐Chang Wang Wolfram Scheurlen Charles G. Eberhart Michelle Fèvre‐Montange Anne Jouvet Ian F. Pollack Xing Fan Karin M. Muraszko G. Yancey Gillespie Concezio Di Rocco Luca Massimi Erna Michiels Nanne K. Kloosterhof Pim J. French Johan M. Kros James M. Olson Richard G. Ellenbogen Karel Zitterbart Leoš Křen Reid C. Thompson Michael K. Cooper Bolesław Lach Roger E. McLendon Darell D. Bigner Adam M. Fontebasso Steffen Albrecht Nada Jabado Janet C. Lindsey Simon Bailey Nalin Gupta William A. Weiss László Bognár Álmos Klekner Timothy Van Meter Toshihiro Kumabe Teiji Tominaga Samer K. Elbabaa Jeffrey R. Leonard Joshua B. Rubin

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique...

10.1038/nature11327 article EN cc-by-nc-sa Nature 2012-07-24

Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma genes have not been defined and screening guidelines for genetic counselling testing paediatric patients are available. We aimed to assess define these provide evidence future guidelines.

10.1016/s1470-2045(18)30242-0 article EN cc-by-nc-nd The Lancet Oncology 2018-05-09

We describe a new method, Tag-seq, which employs ultra high-throughput sequencing of 21 base pair cDNA tags for sensitive and cost-effective gene expression profiling. compared Tag-seq data to LongSAGE observed improved representation several classes rare transcripts, including transcription factors, antisense intronic sequences, the latter possibly representing novel exons or genes. increases in diversity, abundance, dynamic range such transcripts took advantage greater identify, cancers...

10.1101/gr.094482.109 article EN cc-by-nc Genome Research 2009-06-18
A. Sorana Morrissy Livia Garzia David Shih Scott Zuyderduyn Xi Huang and 95 more Patryk Skowron Marc Remke Florence M.G. Cavalli Vijay Ramaswamy Patricia Lindsay Salomeh Jelveh Laura Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew Roth Sohrab P. Shah Hamza Farooq Noriyuki Kijima Borja Holgado John J. Y. Lee Stuart Matan-Lithwick Jessica Liu Stephen C. Mack Alex Manno Kulandaimanuvel Antony Michealraj Carolina Nör John Peacock Lei Qin Jüri Reimand Adi Rolider Yuan Thompson Xiaochong Wu Trevor J. Pugh Adrian Ally Mikhail Bilenky Yaron S.N. Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard Corbett Noreen Dhalla Anyuan He Darlene Lee Haiyan I. Li William D. Long Michael Mayo Patrick Plettner Jenny Q. Qian Jacqueline E. Schein Angela Tam Tina Wong İnanç Birol Yongjun Zhao Cláudia C. Faria José Pimentel Sofía Nunes Tarek Shalaby Michael Grotzer Ian F. Pollack Ronald L. Hamilton Xiao‐Nan Li Anne Bendel Daniel W. Fults Andrew W. Walter Toshihiro Kumabe Teiji Tominaga V. Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H. Wisoff James H. Garvin Duncan Stearns Luca Massimi Ulrich Schüller Jaroslav Štěrba Karel Zitterbart Stéphanie Puget Olivier Ayrault Sandra E. Dunn Daniela Pretti da Cunha Tirapelli Carlos Gilberto Carlotti Helen Wheeler Andrew R. Hallahan Wendy J. Ingram Tobey J. MacDonald Jeffrey J. Olson Erwin G. Van Meir Ji-Yeoun Lee Kyu‐Chang Wang

10.1038/nature16478 article EN Nature 2016-01-01

Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, histologic variant. Stark prognostic genetic differences among the subgroups suggest that subgroup-specific biomarkers could improve prognostication.Molecular were identified from a discovery set 673 medulloblastomas 43 cities around world. Combined risk stratification models...

10.1200/jco.2013.50.9539 article EN Journal of Clinical Oncology 2014-02-04
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin‐Chan and 95 more Alexandre Vasiljevic Joseph Norman Paul Guilhamon Livia Garzia Natalia R. Agamez Mei Lu Tiffany Sin Yu Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline Cristiane Planello Constanze Zeller Dalia Baršytė-Lovejoy Lucie Lafay‐Cousin Louis Létourneau Mathieu Bourgey Man Yu Deena M.A. Gendoo Misko Dzamba Mark Barszczyk Tiago da Silva Medina Alexandra N. Riemenschneider A. Sorana Morrissy Young‐Shin Ra Vijay Ramaswamy Marc Remke Christopher Dunham Stephen Yip Ho‐Keung Ng Jian‐Qiang Lu Vivek Mehta Steffen Albrecht José Pimentel Jennifer A. Chan Gino R. Somers Cláudia C. Faria Lúcia Roque Maryam Fouladi Lindsey M. Hoffman Andrew S. Moore Yin Wang Seung Ah Choi Jordan R. Hansford Daniel Catchpoole Diane K. Birks Nicholas K. Foreman Doug Strother Álmos Klekner László Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy Van Meter Eugene Hwang Amar Gajjar Shih‐Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel W. Fults Takafumi Wataya Chris Fryer David D. Eisenstat Katrin Scheinemann Adam Fleming Donna L. Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A. Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G. Grundy Rishi Lulla Jason Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C. Jane McGlade Theodore Nicolaides Tarık Tihan Joanna J. Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D. Bader Alyssa Reddy G. Yancey Gillespie Monika Warmuth‐Metz

10.1016/j.ccell.2016.11.003 article EN publisher-specific-oa Cancer Cell 2016-12-01

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT medulloblastoma have not been described. Hence, we sought describe these their impact a subgroup-specific manner. We analyzed by direct sequencing genotyping 466 medulloblastomas. The mutational distributions determined according subgroup affiliation, demographics, clinical,...

10.1007/s00401-013-1198-2 article EN cc-by Acta Neuropathologica 2013-10-30

Although replication repair deficiency, either by mismatch deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark MMRD alone. By genome-wide analysis tumors with germline and somatic deficiencies repair, we reveal novel association between proofreading MSI, especially when both components are lost. Analysis indels microsatellites (MS-indels) identified five distinct signatures (MS-sigs)....

10.1158/2159-8290.cd-20-0790 article EN Cancer Discovery 2020-12-18
Patryk Skowron Hamza Farooq Florence M.G. Cavalli A. Sorana Morrissy Michelle Ly and 94 more Liam D. Hendrikse Evan Y. Wang Haig Djambazian Helen Zhu Karen Mungall Quang M. Trinh Tina Zheng Shizhong Dai Ana Guerreiro Stücklin Maria C. Vladoiu Vernon Fong Borja Holgado Carolina Nör Xiaochong Wu Diala Abd-Rabbo Pierre Bérubé Yu Chang Wang Betty Luu Raúl A. Suárez Avesta Rastan Aaron H. Gillmor John J. Y. Lee Xiaoyun Zhang Craig Daniels Peter B. Dirks David Malkin Éric Bouffet Uri Tabori James Loukides François Doz Franck Bourdeaut Olivier Delattre Julien Masliah‐Planchon Olivier Ayrault Seung-Ki Kim David Meyronet Wiesława Grajkowska Carlos Gilberto Carlotti Carmen de Torres Jaume Mora Charles G. Eberhart Erwin G. Van Meir Toshihiro Kumabe Pim J. French Johan M. Kros Nada Jabado Bolesław Lach Ian F. Pollack Ronald L. Hamilton Amulya A. Nageswara Rao Caterina Giannini James M. Olson László Bognár Álmos Klekner Karel Zitterbart Joanna J. Phillips Reid C. Thompson Michael K. Cooper Joshua B. Rubin Linda M. Liau Miklós Garami Péter Hauser Kay Ka Wai Li Ho‐Keung Ng Wai Sang Poon G. Yancey Gillespie Jennifer A. Chan Shin Jung Roger E. McLendon Eric M. Thompson David Zagzag Rajeev Vibhakar Young Seob Shin Maria Luisa Garrè Ulrich Schüller Tomoko Shofuda Cláudia C. Faria Enrique López‐Aguilar Gelareh Zadeh Chi‐chung Hui Vijay Ramaswamy Swneke D. Bailey Steven J.M. Jones Andrew J. Mungall Richard A. Moore John A. Calarco Lincoln Stein Gary D. Bader Jüri Reimand Jiannis Ragoussis William A. Weiss Marco A. Marra Hiromichi Suzuki Michael D. Taylor

Abstract Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers the developing central nervous system. Here, we use unbiased sequencing transcriptome across large cohort 250 tumors to reveal differences among molecular subtypes disease, demonstrate previously unappreciated importance non-coding RNA transcripts. We identify alterations within cAMP dependent pathway ( GNAS , PRKAR1A ) which converge on GLI2 activity show that 18% have genetic event...

10.1038/s41467-021-21883-0 article EN cc-by Nature Communications 2021-03-19

Abstract Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% G4 medulloblastoma). In contrast, highly similar SHH distinct diametrically opposed gain-of-function mutations copy number gains (20% Overexpression...

10.1038/s41588-024-02014-z article EN cc-by Nature Genetics 2025-01-03
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