Sheila K. Singh
A5002640598- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Microtubule and mitosis dynamics
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Chemical Reactions and Isotopes
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
McMaster University
2016-2025
Discovery Centre
2012-2024
McMaster Children's Hospital
2011-2023
Queen's University
2023
University of Toronto
2003-2021
Hamilton Health Sciences
2017-2021
Hamilton General Hospital
2021
Population Health Research Institute
2018-2019
Queen's Medical Centre
2019
National Institute for Health Research
2019
Glioblastoma (GBM) patients suffer from a dismal prognosis, with standard of care therapy inevitably leading to therapy-resistant recurrent tumors. The presence cancer stem cells (CSCs) drives the extensive heterogeneity seen in GBM, prompting need for novel therapies specifically targeting this subset tumor-driving cells. Here, we identify CD70 as potential therapeutic target GBM CSCs.
Abstract Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% G4 medulloblastoma). In contrast, highly similar SHH distinct diametrically opposed gain-of-function mutations copy number gains (20% Overexpression...
Abstract Medulloblastoma is the most common malignant brain tumor in children. This disease heterogeneous and composed of four subtypes medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, 4]. An immediate goal to identify novel molecular targets for aggressive forms medulloblastoma. Polo-like kinase 1 (PLK1) an oncogenic that controls cell cycle proliferation, making it a strong candidate treatment. In this study, pediatric medulloblastomas were subtyped two patient cohorts (discovery...
The Y-box binding protein 1 (YB-1) is upregulated in many human malignancies including glioblastoma (GBM). It also essential for normal brain development, suggesting that YB-1 part of a neural stem cell (NSC) network. Here, we show was highly expressed the subventricular zone (SVZ) mouse fetal tissues but not terminally differentiated primary astrocytes. Conversely, knockout mice had reduced Sox-2, nestin, and musashi-1 expression SVZ. Although murine neurospheres were rich YB-1, its lost...
In this manuscript, we use genetic data to provide a three-faceted analysis on the links between molecular subclasses of glioblastoma, epithelial-to-mesenchymal transition (EMT) and CD133 cell surface protein. The contribution paper is three-fold: First, newly identified signature for in human mammary epithelial cells, demonstrate that genes have significant overlap with differentially expressed all known GBM subtypes. However, up regulated mesenchymal subtype EMT was more than other Second,...
Background. Few protocols exist for returning children/youth to school after concussion. Childhood concussion can significantly affect performance, which is vital social development, academic learning, and preparation future roles. The goal of this knowledge translation research was develop evidence based materials inform physicians about pediatric Methods. Return School (RTS) protocol developed following the National Institute Health Care Excellence procedures. Results. Based on a scoping...
The reported risk factors for glioblastoma (GBM), i.e., ionizing radiation, Li-Fraumeni syndrome, Neurofibromatosis I, and Turcot also increase the of other brain tumor types. Risk human GBM are associated with different oncogenic mutation profiles. Pedigreed domestic dogs a shorter nose flatter face (brachycephalic dogs) display relatively high rates glioma formation. genetic profiles canine gliomas idiosyncratic. association putatively mutational patterns in humans canines suggests that...