A5034601903- CAR-T cell therapy research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- interferon and immune responses
- Glioma Diagnosis and Treatment
- Biofuel production and bioconversion
- biodegradable polymer synthesis and properties
- Respiratory viral infections research
- Autoimmune Neurological Disorders and Treatments
- Privacy-Preserving Technologies in Data
- Viral gastroenteritis research and epidemiology
- Supercapacitor Materials and Fabrication
- Adversarial Robustness in Machine Learning
- Biopolymer Synthesis and Applications
- Plant biochemistry and biosynthesis
- Semiconductor materials and devices
- Cytomegalovirus and herpesvirus research
- Cryptography and Data Security
- Cancer Cells and Metastasis
- Microbial Metabolic Engineering and Bioproduction
- Genetic Neurodegenerative Diseases
- Animal Virus Infections Studies
- Immune cells in cancer
- Poverty, Education, and Child Welfare
- Layered Double Hydroxides Synthesis and Applications
Kookmin University
2022
Kongju National University
2022
McMaster University
2020-2022
Institute of Nano Science and Technology
2022
Mayo Clinic in Arizona
2017-2020
Kathmandu University
2015
University of Aberdeen
1970
Abstract Oncolytic virus therapy leads to immunogenic death of virus-infected tumor cells and this has been shown in preclinical models enhance the cytotoxic T-lymphocyte response against tumor-associated antigens (TAAs), leading killing uninfected cells. To investigate whether oncolytic virotherapy can increase immune responses human subjects, we studied T-cell a panel known myeloma TAAs using PBMC samples obtained from ten patients before after systemic administration an measles encoding...
Glioblastoma (GBM) patients suffer from a dismal prognosis, with standard of care therapy inevitably leading to therapy-resistant recurrent tumors. The presence cancer stem cells (CSCs) drives the extensive heterogeneity seen in GBM, prompting need for novel therapies specifically targeting this subset tumor-driving cells. Here, we identify CD70 as potential therapeutic target GBM CSCs.
Brain metastases (BM) are mainly treated palliatively with an expected survival of less than 12 months after diagnosis. In many solid tumors, the human neural stem cell marker glycoprotein CD133 is a tumor-initiating population that contributes to therapy resistance, relapse, and metastasis.
Mg-ion supercapacitors (SCs) can be a potential candidate for advanced electrochemical energy storage devices because they are low-cost and safe have long-term cycling stability. However, exhibiting high density while preserving power is still challenge supercapacitors, which limits their practical applications. Herein, we proposed cathode CoMn2O4 nanospheres embedded in N-doped graphene (CMO/G-N) prepared via an improvised hydrothermal route. The material exhibited capacitance of 691 F g–1...
<div>AbstractPurpose:<p>Brain metastases (BM) are mainly treated palliatively with an expected survival of less than 12 months after diagnosis. In many solid tumors, the human neural stem cell marker glycoprotein CD133 is a tumor-initiating population that contributes to therapy resistance, relapse, and metastasis.</p>Experimental Design:<p>Here, we use variant our previously described binder generate second-generation CD133-specific chimeric antigen receptor T cells...
Abstract The importance of computing and storage capacity has increased over time, the data mining in industrial engineering become more apparent. Recently, artificial intelligence machine learning have made significant advancements engineering. Federated is a technique that aims to solve problem distributed systems their applications while ensuring privacy. Tolpegin et al. conducted research on poisoning attacks federated system, which we extended an analysis efficiency Tolpegin's proposed...
Abstract Introduction. VSV-IFNβ-NIS is an oncolytic vesicular stomatitis virus (VSV; Rhabdovirus family) with rapid replication kinetics and potent antitumor activity. encodes the human interferon beta (IFNβ) gene as a STING agonist sodium iodide symporter (NIS) reporter for tracking pharmacokinetics (PK) of in infected tumors. VSV replicates selectively cancer cells has promising preclinical activity across broad spectrum types. We report here safety correlative data from FIH trial...
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<div>AbstractPurpose:<p>Brain metastases (BM) are mainly treated palliatively with an expected survival of less than 12 months after diagnosis. In many solid tumors, the human neural stem cell marker glycoprotein CD133 is a tumor-initiating population that contributes to therapy resistance, relapse, and metastasis.</p>Experimental Design:<p>Here, we use variant our previously described binder generate second-generation CD133-specific chimeric antigen receptor T cells...
In this study, the effect of applying nutrient limitation on production Poly-hydro-oxy-butyric acid (PHB) from soil bacteria was examined. PHB is a biodegradable polymer which provides reserve carbon and energy. extracted by chloroform dispersion method. The amount synthesized determined as crotonic spectrophotometry. We found that Nitrogen limiting condition stimulated accumulation. highest level accumulation observed in DNB-6 strain accumulated 31 % dry mass at 20 glucose concentration....
218 Background: Evidence from mouse studies shows that Oncolytic viral mode of tumor cell killing can boost the cytotoxic T lymphocyte response against associated antigens (TAA), leading to ‘bystander’ uninfected cells. Methods: To investigate whether oncolytic virotherapy immune responses in human subjects we studied 10 different TAA reported have high expression patients with multiple myeloma (n = 10) before and after intravenous administration an measles virus (MV-NIS). Baseline 6 week...
Abstract Introduction Voyager-V1TM is derived from VSV, a bullet-shaped negative sense RNA virus with very low human seroprevalence; it engineered to selectively replicate in and kill cancer cells. Voyager-V1 encodes the IFNβ gene boost antitumoral immune responses thyroidal sodium iodide symporter NIS permit noninvasive imaging of spread. FIH studies are underway via both IV IT routes. Here we report safety preliminary correlative data study. Methods objectives This classical 3+3 phase 1...
Anti-N-Methyl-D-Aspartate Receptor (anti-NMDAR) has been the first specific-antibody type to be associated with Autoimmune Encephalitis [1]. encephalitis is neuropsychiatric symptoms including abrupt personality changes, cognitive decline, memory loss, perceptual disturbances among many others. Initial presentation might range from agitation, psychosis, and changes in speech, hallucinations, involuntary motor movements autonomic dysfunction [2]. In general adult population are found have...
Abstract Introduction. Voyager-V1 (VV1) is an oncolytic vesicular stomatitis virus engineered to express human interferon beta (IFNβ) enhance cellular antitumor immune responses and tumor selectivity. VV1 also contains the sodium iodide symporter (NIS) as imaging gene. We report here novel use of virus-encoded IFNβ a PD marker using correlative data from three Phase I trials VSV-IFNβ-NIS in patients with refractory cancers (n=46). Methods. 46 solid tumors (n=34) hematological malignancies...
ABSTRACT Purpose Glioblastoma (GBM) patients suffer from a dismal prognosis, with standard of care therapy inevitably leading to therapy-resistant recurrent tumors. The presence brain tumor initiating cells (BTICs) drives the extensive heterogeneity seen in GBM, prompting need for novel therapies specifically targeting this subset tumor-driving cells. Here we identify CD70 as potential therapeutic target GBM BTICs. Experimental Design In current study, identified relevance and functional...