A5047821348- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cancer Cells and Metastasis
- Head and Neck Surgical Oncology
- Neurogenesis and neuroplasticity mechanisms
- Pituitary Gland Disorders and Treatments
- RNA Research and Splicing
- 3D Printing in Biomedical Research
- Cerebrospinal fluid and hydrocephalus
- Nuclear Structure and Function
- Craniofacial Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Vascular Malformations Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Nuclear Receptors and Signaling
Kitasato University
2018-2024
Kumamoto University
2010-2020
University of Toronto
2004
Hospital for Sick Children
2004
SickKids Foundation
2004
Southern General Hospital
1982-1997
Oita Prefectural Hospital
1997
Glasgow Life
1995
Kumamoto Medical Center
1994
Japanese Red Cross Kumamoto Hospital
1994
Recent findings have demonstrated that malignant tumors, including glioblastoma multiforme, contain cancer-initiating cells (also known as cancer stem cells), which self-renew and are malignant, with features of tissue-specific cells. As these resistant to irradiation anti-cancer drugs, it is important characterize them find targeting therapies. In this study, we established two primary human glioma cell lines from anaplastic oligodendroglioma multiforme. These were enriched in...
Glioblastoma (GBM) usually develops in adult brain white matter. Even after complete resection, GBM recurs around the tumor removal cavity, where cells acquire chemo-radioresistance. Characterization of border microenvironment is critical for improving prognosis patients with GBM. Here, we compared microRNA (miRNA) expression samples from tumor, border, and periphery by miRNA microarray. The top three miRNAs showing higher were related to oligodendrocyte differentiation, pathologically...
Abstract Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs not been characterized properly due to lack of specific markers. We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRasL61 in p53-deficient neural stem cells. Using limiting dilution assays, we show only 2 24 NSCL61 clones retained their tumorigenicity vivo, although the others also expressed could...
To avoid disorientation during endoscopic endonasal transsphenoidal surgery (ETSS), the confirmation of anatomical landmarks is essential. Neuronavigation systems can be pointed at exact sites, but their spatial resolution power too low for detection vessels that cannot seen on MR images. On Doppler ultrasonography shape concealed arteries and veins visualized. address these problems, authors evaluated clinical usefulness indocyanine green (ICG) endoscope.The included 38 patients with...
The potential for a tumor of the upper face, either malignant or nonmalignant, to involve anterior cranial base is often not appreciated. This leads inadequate preoperative investigation and surgery performed by head neck surgeon without help neurosurgeon. In this way, complete resection may be compromised delayed. Neither these situations desirable. If fossa invasion recognized, there should prior consultation with neurosurgeon combined operative procedure. Exposure lesions has considerably...
Mice heterozygous for the Otx2 mutation display a craniofacial malformation, known as otocephaly or agnathia-holoprosencephaly complex. The severity of phenotype is dependent on genetic background C57BL/6 (B6) strain; most offspring knock-out chimeras, which are equivalent to F1 CBA and B6 strains, backcrossed with females reduction loss mandible, whereas those do not show noticeable at birth. availability phenotypically disparate strains renders identification modifier loci possible. In...
Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates diverse physiological functions, including cell proliferation and survival. Recent studies have shown IL-6 expression often elevated in response to several types of glioma. Although said play an important role glioma, the involvement signaling has been quite controversial. The aim this study was evaluate glioma inhibitory effect on tumor proliferation.The receptors (IL-6Rs) evaluated tissues by means immunohistochemical analysis,...
Recent findings have demonstrated that malignant tumors, including glioblastoma multiforme (GBM), contain cancer-initiating cells (CICs; also known as cancer stem cells), which self-renew and are malignant. However, it remains controversial whether such CICs arise from tissue-specific cells, committed precursor or differentiated cells. Here, we sought to examine the origin of in GBM. We first showed overexpression oncogenic HRas(L61) transformed p53-deficient oligodendrocyte (OPCs) neural...
Endoscopic surgery is suitable for the transsphenoidal approach; it minimally invasive and provides a well-lit operative field. The endoscopic skull base approach through large opening of sphenoid sinus both nostrils has extended surgical indication various lesions. In this study, we describe efficacy complications associated with extra- or intradural parasellar lesions based on our experiences.Seventy-four cases were treated by an approach. indications these procedures included 55 anterior...
Cylindromatosis (CYLD) is a tumor suppressor that regulates signaling pathways by acting as deubiquitinating enzyme. CYLDdown-regulation occurred in several malignancies, with tumor-promoting effects. Although we found loss of CYLD expression hypoxic regions human glioblastoma multiforme (GBM), the most aggressive brain tumor, biological roles GBM remain unknown. This study aimed to determine significance down-regulation progression and therapy. mRNA transcription was dramatically...
Ecchordosis physaliphora (EP) is a benign notochordal remnant that usually asymptomatic; symptomatic cases are extremely rare. Most of the reported were managed by resection via craniotomy.We report case 20-year-old male presenting with abducens nerve palsy. Magnetic resonance imaging performed on admission demonstrated mass in retroclival prepontine location. The patient was treated successfully endoscopic endonasal trans-sphenoidal surgery (ETSS), his postoperative course uneventful, and...
Tumor biomarkers play an essential role in immunotherapeutic strategies cancer treatment, contributing to early diagnosis, patient selection, treatment monitoring, and personalized plans. Despite their importance care, circulating may not always be detectable or sufficiently elevated provide reliable test results. Due the pressing need for innovative approaches enhance biomarker levels, this study explored potential use of focused shock waves cavitation non-invasively releasing...
To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. We studied 267 gliomas, which included 171 glioblastomas (GBMs), 40 anaplastic astrocytomas (AAs), 30 oligodendrogliomas (AOs), 26 oligoastrocytomas (AOAs). These gliomas were divided into 2 groups (Group 1: GBM + AA, Group 2: AO AOA) according to presence oligodendroglioma...