A5005700148- Vietnamese History and Culture Studies
- Southeast Asian Sociopolitical Studies
- Historical Studies and Socio-cultural Analysis
- Asian Geopolitics and Ethnography
- Chinese history and philosophy
- Glioma Diagnosis and Treatment
- Health, Medicine and Society
- Cambodian History and Society
- Metabolism and Genetic Disorders
- Ethics in medical practice
- Chromatin Remodeling and Cancer
- Philippine History and Culture
- Mitochondrial Function and Pathology
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Ancient and Medieval Archaeology Studies
- South Asian Studies and Conflicts
- Neurogenetic and Muscular Disorders Research
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Diverse Aspects of Tourism Research
- Meningioma and schwannoma management
- Cancer-related molecular mechanisms research
- Medieval European Literature and History
- Cultural Identity and Heritage
University of Ottawa
2014-2024
Children's Hospital of Eastern Ontario
2013-2024
Université Laval
2012-2024
Information Today (United States)
2023
University of Bonn
2020
Alberta Bible College
2019
Centre Hospitalier Universitaire Sainte-Justine
1989-2018
University of Calgary
2000-2017
Ottawa Hospital
2009-2017
McGill University
1993-2017
Motivation: Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression not able to make full use of the resulting information. The usual practice is average triplicate results each probe before expression. This loss valuable information about genewise variability. Results: A method proposed extracting more from within-array replicate spots microarray experiments by estimating strength correlation between them. involves...
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors a higher mortality rate, while high-grade better outcome. However, we little understanding of their biology therefore cannot explain this nor what constitutes optimal management. Here report comprehensive genetic analysis an international cohort clinically annotated infant gliomas, revealing 3 subgroups. Group 1 arise the cerebral hemispheres harbor alterations receptor tyrosine...
Abstract —The mechanisms mediating leukocyte recruitment into the cerebral nervous system during inflammation are still poorly understood. The objective of this study was to investigate in brain microcirculation by intravital microscopy. Superfusion with artificial cerebrospinal fluid did not induce rolling or adhesion. However, intraperitoneal tumor necrosis factor-α (TNF-α) caused marked and adhesion microcirculation. Histology revealed that primarily neutrophils. Both E- P-selectin were...
Hereditary tyrosinemia results from an inborn error in the final step of tyrosine metabolism. The disease is known to cause acute and chronic liver failure, renal Fanconi's syndrome, hepatocellular carcinoma. Neurologic manifestations have been reported but not emphasized as a common problem. In this paper, we describe neurologic crises that occurred among children identified having on neonatal screening since 1970. Of 48 with tyrosinemia, 20 (42 percent) had began at mean age one year led...
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought evaluate diagnostic specificity LIN28, clinical biological spectra amplified and/or LIN28+ CNS-PNETs. We interrogated 450 pediatric brain tumors using FISH IHC analyses demonstrate that alteration is restricted sub-group with expression; however, immunopositivity was not...
Abstract This editorial develops two themes. First, it discusses how historical and anthropological approaches can relate to each other, in the field of highland margins Asia beyond. Second, explores we might further our understandings uplands by applying different terms such as ‘Haute-Asie’, ‘Southeast Asian Massif’, ‘Hindu Kush–Himalayan region’, ‘Himalayan particular ‘Zomia’, a neologism gaining popularity with publication James C. Scott’s latest book, The art not being governed: an...
Abstract Objective Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to paralysis and subsequent death in young children. Initially considered a motor neuron disease, extra‐neuronal involvement increasingly recognized. The primary goal of this study was investigate alterations lipid metabolism SMA patients mouse models the disease. Methods We analyzed clinical data collected from large cohort pediatric type I–III as well I liver necropsy data. In parallel, we...
Tay-Sachs and Sandhoff diseases are autosomal recessive neurodegenerative resulting from the inability to catabolize GM2 ganglioside by β-hexos-aminidase A (Hex A) due mutations of α subunit (Tay-Sachs disease) or β (Sandhoff Hex A. B ( ββ homodimer) is also defective in disease. We previously developed mouse models both showed that Hexa-−/− (Tay-Sachs) mice remain asymptomatic at least 1 year age while Hexb−/− (Sandhoff) succumb a profound disease 4–6 months age. Here we find neuron death...
<b><i>Objective:</i></b> To clarify the clinical features and pathologic manifestations of isolated angiitis CNS (IACNS) in children. <b><i>Methods:</i></b> The authors report two new cases summarize literature childhood IACNS confirmed by pathology. <b><i>Results:</i></b> affecting small vessels (n = 5)—Neurologic included headaches, focal seizures, progressive, behavioral, or multifocal neurologic impairment. MRI showed multifocal, T2-hyperintense, cerebral lesions without mass effect...
This paper is an overview of issues pertaining to highland minorities in the three socialist countries sharing portions Southeast Asian Massif, namely China, Vietnam and Laos. It presents historical complexity minority policy these countries. The thus depicts prevalent state strategies that aimed, largely still aim, handle most effective economical way, ensure nation will progress steadily forward. six current borders transnationality, taxonomy, indigenous peoples' status, customary land...
Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and healthcare systems. Current preclinical models of NAFLD are invariably imperfect generally take long time to develop. A mouse model survival motor neuron (SMN) depletion (Smn2B/- mice) was recently shown develop significant hepatic steatosis in less than 2 weeks from birth. The rapid onset Smn2B/- mice provides an opportunity identify molecular markers NAFLD. Here,...