Bruce Crooks
A5085092449- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Ocular Oncology and Treatments
- Meningioma and schwannoma management
- Testicular diseases and treatments
- Genetic factors in colorectal cancer
- Cytomegalovirus and herpesvirus research
- Cannabis and Cannabinoid Research
- Immunodeficiency and Autoimmune Disorders
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- Neonatal Health and Biochemistry
- Brain Metastases and Treatment
- Blood disorders and treatments
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Hematopoietic Stem Cell Transplantation
- Autoimmune and Inflammatory Disorders Research
- Tumors and Oncological Cases
- Immune Cell Function and Interaction
- Chemotherapy-induced cardiotoxicity and mitigation
- Retinopathy of Prematurity Studies
Dalhousie University
2011-2025
Izaak Walton Killam Health Centre
2016-2025
St Christopher's Hospice
2022
University of Toronto
2022
University of British Columbia
2022
George & Fay Yee Centre for Healthcare Innovation
2022
University of Manitoba
2022
CancerCare Manitoba
2022
NeuroDevNet
2022
Beatrice Hunter Cancer Research Institute
2022
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors a higher mortality rate, while high-grade better outcome. However, we little understanding of their biology therefore cannot explain this nor what constitutes optimal management. Here report comprehensive genetic analysis an international cohort clinically annotated infant gliomas, revealing 3 subgroups. Group 1 arise the cerebral hemispheres harbor alterations receptor tyrosine...
Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition characterized by early-onset synchronous and metachronous multiorgan tumors. We designed surveillance protocol for early tumor detection in these individuals.Data were collected from patients with confirmed CMMRD who registered the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of protocol, malignant transformation low-grade lesions examined entire cohort. Survival...
Abstract BACKGROUND Most reported data of chemoradiotherapy protocols for the treatment medulloblastoma describe children who were treated in first decade life. To consider feasibility this approach adolescents, authors studied their clinical course with specific emphasis on toxicity, tolerability, and prognosis. METHODS In retrospective study, examined toxicity profiles outcomes age 10–20 years at centers throughout Canada between 1986 2003. Detailed from 2 chemotherapy collected teenagers...
Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood (iMB) has no standard care at relapse. This work aimed to evaluate post-relapse survival (PRS) explore prognostic factors patients with nodular desmoplastic (ND) and/or SHH iMB. international retrospective study included 147 subjects diagnosed relapsed Nodular Desmoplastic/SHH iMB between 1995 2017, < 6 years old original diagnosis, treated without initial craniospinal irradiation (CSI)....
Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer predisposition syndrome caused by biallelic mutations in (MMR) genes. As several syndromes are clinically similar, accurate diagnosis critical to screening and treatment. genetic confounded 15 or more pseudogenes variants of uncertain significance, robust diagnostic assay urgently needed. We sought determine whether an that directly measures MMR activity could accurately diagnose CMMRD.In vitro was quantified...
Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential to understand treatment trends interpret national survival data. In Canada, children with treated at one 16 tertiary care centers. We surveyed pediatric neuro-oncologists create a standard practice be used absence clinical trial for seven most prevalent brain children. This allowed description across country, along consensus. had multitude benefits, including understanding patterns, allowing basis...
Abstract Mismatch repair (MMR) is a critical defence against mutation, but we lack quantification of its activity on different DNA lesions during human life. We performed whole-genome sequencing normal and neoplastic tissues from individuals with constitutional MMR deficiency to establish the roles components, tissue type disease state in somatic mutation rates. Mutational signatures varied extensively across genotypes, some coupled leading-strand replication, lagging-strand replication...
Abstract Background There are very few studies about the role of repeat irradiation (RT2) for children with recurrent supratentorial high‐grade glioma (HGG). It was aim this study to assess effectiveness and safety RT2 in population. Procedure This a retrospective cohort 40 age 18 years under HGG who had received at least one course RT. In‐field reirradiation volumes included focal or whole brain RT, doses ranging from 30 54 Gy. The primary endpoint overall survival (OS) first day RT2....
Abstract Background Children with cancer are increasingly using cannabis therapeutically. Aim The purpose of this study was to determine the perspectives and practices pediatric oncologists palliative care physicians regarding use for medical purposes among children cancer. Methods A self‐administered, voluntary, cross‐sectional, deidentified online survey sent all in Canada between June August 2020. Survey domains included education, knowledge, concerns about cannabis, views on its...
The treatment of BRAF V600E gliomas with inhibitors (BRAFis) and MEK (MEKis) has been increasingly integrated into clinical practice for pediatric low-grade (PLGGs) high-grade (HGGs). However, some questions remain unanswered, such as the best time to start targeted therapy, duration treatment, discontinuation therapy. Given that no trial able address these critical questions, we developed a Canadian Consensus statement mutated well adolescent young adult (AYA) gliomas.