A5042729959- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Cancer Treatment and Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Childhood Cancer Survivors' Quality of Life
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
- Vascular Malformations Diagnosis and Treatment
- DNA Repair Mechanisms
- Family Support in Illness
- Nanoplatforms for cancer theranostics
- Ocular Oncology and Treatments
- Melanoma and MAPK Pathways
- Teratomas and Epidermoid Cysts
- Cannabis and Cannabinoid Research
- Redox biology and oxidative stress
- Sarcoma Diagnosis and Treatment
CancerCare Manitoba
2015-2024
Research Institute in Oncology and Hematology
2015-2024
University of Manitoba
2015-2024
Children's Hospital of Winnipeg
2015-2021
Montreal Children's Hospital
2021
McGill University
2021
University College London
2021
SickKids Foundation
2021
Hospital for Sick Children
2021
Great Ormond Street Hospital
2021
Although replication repair deficiency, either by mismatch deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark MMRD alone. By genome-wide analysis tumors with germline and somatic deficiencies repair, we reveal novel association between proofreading MSI, especially when both components are lost. Analysis indels microsatellites (MS-indels) identified five distinct signatures (MS-sigs)....
The objective was to evaluate the reliability and validity of self-report Symptom Screening in Pediatrics Tool (SSPedi) from perspective children with cancer pediatric hematopoietic stem cell transplant (HSCT) recipients. In this multicenter study, respondents were age eight 18 years who had or received HSCT, their parents. Two different child respondent populations targeted. More symptomatic receiving active treatment for cancer, admitted hospital, expected be hospital three days later....
Abstract Objective Clinical trials have failed to demonstrate a survival benefit of adjuvant chemotherapy in diffuse intrinsic pontine gliomas (DIPG). Radiation therapy (RT) is the only effective treatment thus far and reirradiation (rRT) has become an option at time progression. The aim this study was review Canadian experience DIPG rRT with focus on safety possible efficacy approach. Method We retrospectively reviewed demographic, clinical, RT data patients treated Canada rRT. Results...
Abstract Immune checkpoint inhibition (ICI) is effective for replication-repair-deficient, high-grade gliomas (RRD-HGG). The clinical/biological impact of immune-directed approaches after failing ICI monotherapy unknown. We performed an international study on 75 patients treated with anti–PD-1; 20 are progression free (median follow-up, 3.7 years). After second progression/recurrence (n = 55), continuing ICI-based salvage prolonged survival to 11.6 months 38; P < 0.001), particularly...
Abstract Objectives were to describe any bothersome symptom and severely symptoms in inpatient children with cancer hematopoietic stem cell transplant ( HSCT ) recipients. We included 8–18 years of age or recipients who receiving active treatment for cancer, admitted hospital, expected be hospital 3 days later. administered the self‐report Symptom Screening Pediatrics Tool SSP edi). described those identified degree bother (at least “a little”) rated as severe (“a lot” “extremely”). Factors...
PURPOSE Diagnosis of Mismatch Repair Deficiency (MMRD) is crucial for tumor management and early detection in patients with the cancer predisposition syndrome constitutional mismatch repair deficiency (CMMRD). Current diagnostic tools are cumbersome inconsistent both childhood cancers determining germline MMRD. PATIENTS AND METHODS We developed analyzed a functional Low-pass Genomic Instability Characterization (LOGIC) assay to detect The performance LOGIC was compared that current...
High-grade gliomas (HGGs) constitute ∼15% of all primary brain tumors in children and adolescents. Routine histopathological diagnosis is based on tissue obtained from biopsy or, preferably, the resected tumor itself. The majority pediatric HGGs are clinically biologically distinct histologically similar adult malignant gliomas; these differences may explain disparate responses to therapy clinical outcomes when comparing adults with HGG. recently proposed integrated genomic classification...
Pediatric patients with cancer experience severely bothersome symptoms during treatment. It was hypothesized that symptom screening and provision of reports to the health care team would reduce burden in pediatric cancer.
Primary CNS tumors are the leading cause of cancer-related death in pediatrics. It is essential to understand treatment trends interpret national survival data. In Canada, children with treated at one 16 tertiary care centers. We surveyed pediatric neuro-oncologists create a standard practice be used absence clinical trial for seven most prevalent brain children. This allowed description across country, along consensus. had multitude benefits, including understanding patterns, allowing basis...
Spermidine/spermine N1-acetyltransferase 1 (SAT1) responsible for cell polyamine catabolism is overexpressed in glioblastoma multiforme (GB). Its role tumor survival and promoting resistance towards radiation therapy has made it an interesting target therapy. In this study, we prepared a lipid nanoparticle-based siRNA delivery system (LNP-siSAT1) to selectively knockdown (KD) SAT1 enzyme human line. The LNP-siSAT1 containing ionizable DODAP was following microfluidics mixing method the...
We report a case of slipped capital femoral epiphysis (SCFE), an on target skeletal toxicity pan-FGFR TKI inhibitor, erdafitinib. A 13-year-old boy was diagnosed to have optic pathway/hypothalamic glioma with signs increased intracranial pressure and obstructive hydrocephalus requiring placement ventriculo-peritoneal (VP) shunt. Sequencing the tumor showed FGFR1-tyrosine kinase domain internal tandem duplication (FGFR1-KD-ITD). He developed hypothalamic obesity rapid weight gain BMI...
Abstract Background Children with cancer are increasingly using cannabis therapeutically. Aim The purpose of this study was to determine the perspectives and practices pediatric oncologists palliative care physicians regarding use for medical purposes among children cancer. Methods A self‐administered, voluntary, cross‐sectional, deidentified online survey sent all in Canada between June August 2020. Survey domains included education, knowledge, concerns about cannabis, views on its...
The treatment of BRAF V600E gliomas with inhibitors (BRAFis) and MEK (MEKis) has been increasingly integrated into clinical practice for pediatric low-grade (PLGGs) high-grade (HGGs). However, some questions remain unanswered, such as the best time to start targeted therapy, duration treatment, discontinuation therapy. Given that no trial able address these critical questions, we developed a Canadian Consensus statement mutated well adolescent young adult (AYA) gliomas.
The blood-brain barrier (BBB) poses a major obstacle by preventing potential therapeutic agents from reaching their intended brain targets at sufficient concentrations. While transient disruption of the BBB has been used to enhance chemotherapeutic efficacy in treating tumors, limitations terms magnitude and duration exist. In present study, preliminary safety profile HAV6, peptide that binds external domains cadherin, transiently open improve delivery agent, was evaluated murine tumor...
Abstract Neurofibromatosis type 1‐associated plexiform neurofibromas can cause debilitating symptoms and be life threatening. Treatment options are limited, given their tendency to regrow following surgery propensity transform into malignant tumours radiation. Selumetinib is an oral selective inhibitor of RAS‐mitogen‐activated protein kinase (MAPK) 1 2, which has shown efficacy for tumour shrinkage/stabilisation symptom improvement. We report a national case series 19 children treated with...
Abstract Medulloblastoma is a cerebellar tumor and the most common pediatric brain malignancy. Radiotherapy part of standard care for this tumor, but its effectiveness accompanied by significant neurocognitive sequelae due to deleterious effects radiation on developing brain. We have previously shown that protein kinase MRK/ZAK protects cells from radiation-induced cell death regulating cell-cycle arrest after ionizing radiation. Here, we show siRNA-mediated MRK depletion sensitizes...