A5047531932- Cannabis and Cannabinoid Research
- Pharmaceutical studies and practices
- Prenatal Substance Exposure Effects
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 Clinical Research Studies
- Meta-analysis and systematic reviews
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- COVID-19 and Mental Health
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Adolescent and Pediatric Healthcare
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Pharmacological Effects and Toxicity Studies
- Childhood Cancer Survivors' Quality of Life
- Homelessness and Social Issues
- Neonatal Health and Biochemistry
- Opioid Use Disorder Treatment
- Statistical Methods in Clinical Trials
- Delphi Technique in Research
- Pain Management and Opioid Use
- Attention Deficit Hyperactivity Disorder
University of Manitoba
2018-2025
Children's Hospital Research Institute of Manitoba
2019-2024
George & Fay Yee Centre for Healthcare Innovation
2018-2024
University of Utah
2024
Canadian Paediatric Society
2024
RAND Corporation
2024
Swansea University
2023
Icahn School of Medicine at Mount Sinai
2023
Myeloma UK
2023
Beth Israel Deaconess Medical Center
2022-2023
BackgroundCoronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection SARS-CoV-2 unknown.MethodsWe conducted a randomized, double-blind, placebo-controlled trial across United States parts Canada testing as postexposure prophylaxis. We enrolled adults had household or occupational someone...
No effective oral therapy exists for early coronavirus disease 2019 (COVID-19).
In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer cytochrome P4502D6 (CYP2D6). We now report 3 additional or life-threatening cases from North America. 2 cases, functional gene duplications encoding CYP2D6 caused significantly greater production potent morphine its parent drug, codeine. A severe respiratory depression in extensive is also noted. These demonstrate...
The role of remdesivir in the treatment patients hospital with COVID-19 remains ill defined a global context. World Health Organization Solidarity randomized controlled trial (RCT) evaluated across many countries, Canada enrolling using an expanded data collection format Canadian Treatments for (CATCO) trial. We report on findings, additional demographics, characteristics and clinical outcomes, to explore potential differential effects different health care systems.
BACKGROUND: Pediatric sleep disordered breathing is often caused by hypertrophy of the tonsils and commonly managed tonsillectomy. There controversy regarding which postsurgical analgesic agents are safe efficacious. METHODS: This prospective randomized clinical trial recruited children who had were scheduled for tonsillectomy +/− adenoid removal. Parents provided with a pulse oximeter to measure oxygen saturation apnea events night before after surgery. Children receive acetaminophen either...
Abstract Background Use of hydroxychloroquine in hospitalized patients with coronavirus disease 2019 (COVID-19), especially combination azithromycin, has raised safety concerns. Here, we report data from 3 outpatient randomized clinical trials. Methods We conducted randomized, double-blind, placebo-controlled trials investigating as pre-exposure prophylaxis, postexposure and early treatment for COVID-19 using an internet-based design. excluded individuals contraindications to...
Inadequate and poor quality outcome reporting in clinical trials is a well-documented problem that impedes the ability of researchers to evaluate, replicate, synthesize, build upon study findings impacts evidence-based decision-making by patients, clinicians, policy-makers. To facilitate harmonized transparent outcomes trial protocols published reports, Instrument for Planned Endpoints Clinical Trials (InsPECT) being developed. The final product will provide unique InsPECT extensions SPIRIT...
Background Neonates are commonly exposed to maternal codeine through breast milk. Central Nervous System (CNS) depression has been reported in up 24% of nurslings following exposure. In 2009, we developed guidelines improve the safety use during breastfeeding based on previously established pharmacogenetic and clinical risk factors. The primary objective this study was prospectively evaluate effectiveness these ensuring neonatal safety. Methods Findings Women taking for pain caesarean...
Introduction Opioids are prescribed to manage pain. Approximately 1 in 20 pregnant women Canada opioids during the prenatal period, which may occur concurrently with other psychotropic drug use. The health implications of independent and concurrent use these drugs not fully understood; however, adverse neonatal longer-term outcomes have been suggested. This protocol describes a study update epidemiology exposure opioid pregnancy, providing an enhanced understanding potential impacts on...
Objectives: Individuals with co-occurring opioid use disorder (OUD) and mental health disorders experience complex treatment trajectories. The collaborative care model (CoCM) is an effective approach for improving behavioral outcomes in primary care, but has not been tested patients disorders. We sought to understand patients’ experiences receiving CoCM OUD depression and/or PTSD. Methods: conducted interviews (N=24) who received as part of a randomized trial. was delivered across 18 clinics...