A5031516682- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Venous Thromboembolism Diagnosis and Management
- Hematopoietic Stem Cell Transplantation
- Blood Coagulation and Thrombosis Mechanisms
- Cancer survivorship and care
- Acute Lymphoblastic Leukemia research
- Bone and Joint Diseases
- Sepsis Diagnosis and Treatment
- RNA regulation and disease
- Palliative Care and End-of-Life Issues
- Sarcoma Diagnosis and Treatment
- Signaling Pathways in Disease
- Neurofibromatosis and Schwannoma Cases
- Advances in Oncology and Radiotherapy
- Acute Myeloid Leukemia Research
- Meningioma and schwannoma management
- Lymphatic System and Diseases
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Protein Tyrosine Phosphatases
- Blood disorders and treatments
- Artificial Intelligence in Healthcare and Education
University Malaya Medical Centre
2013-2024
Princess Margaret Hospital for Children
2017-2024
Perth Children's Hospital
2018-2024
SRM Institute of Science and Technology
2024
University of Malaya
2013-2023
Royal Children's Hospital
2023
Cancer Institute (WIA)
2022
HCG Cancer Hospital
2020-2021
Pediatrics and Genetics
2020
CARE Hospitals
2018
Abstract Objective Clinical trials have failed to demonstrate a survival benefit of adjuvant chemotherapy in diffuse intrinsic pontine gliomas (DIPG). Radiation therapy (RT) is the only effective treatment thus far and reirradiation (rRT) has become an option at time progression. The aim this study was review Canadian experience DIPG rRT with focus on safety possible efficacy approach. Method We retrospectively reviewed demographic, clinical, RT data patients treated Canada rRT. Results...
Abstract In pediatric low‐grade gliomas not amenable to complete resection, various chemotherapy regimens are the mainstream of treatment. An excellent overall survival these patients makes justification intensification difficult and calls for development new strategies. Bevacizumab, a humanized monoclonal antibody directed against Vascular endothelial growth factor (VEGF), has been successfully used in combination with irinotecan number adult studies reports. Fifteen at median age 7 years...
Hospital malnutrition is a multi-factorial and complex problem seen in cancer patients receiving treatment, which associated with poorer outcomes. Appropriate foodservice interventions may be required to improve nutritional status, prevent promote patient satisfaction. We introduced implemented patient-centered model the aim of improving patient's overall care enhancing experience. A cross-sectional analysis was done evaluate outcomes between traditional newly model. meal intake observation...
Pediatric medulloblastoma (MB) treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, literature regarding childhood MB Malaysia been nonexistent. Our objectives were to review demographics and outcome of pediatric treated at University Malaya Medical Center between January 1994 December 2013 describe challenges encountered.Fifty-one patients seen Center. Data from 43 analyzed; eight excluded because...
Survivorship in childhood cancers has steadily improved and increased the need for caregivers to provide a longer duration of care both hospital at home. Involving parents voice their unmet needs could significantly impact direct institution support groups.To ascertain pediatric caregiver group based on survey that explored children with cancer.Caregivers patients (n = 17) undergoing treatment were requested complete our Pediatric Caregiver Psycho-social Needs Survey. The encompassed...
Review of the management 6 young girls with vaginal yolk sac tumor over 25 years showed that α-fetoprotein levels normalized in 5/6 within 4 cycles primary cisplatin, bleomycin, etoposide (PEB)/carboplatin, etoposide, bleomycin (JEB)/cisplatin, vinblastine, (PVB) chemotherapy. Radioimaging revealed residual tissue but viable was found only 1 2 biopsied. Resection/biopsy is necessary to avoid giving additional chemotherapy or identify patients who need different treatment. If markers do not...
Chemotherapy is one of the treatment modalities for cancer. The side effects treatment, at times, can affect emotional well-being patients and their caregivers, thereby leading to distress. This paper aims screening identifying levels distress among undergoing chemotherapy caregivers.
Infant and young childhood medulloblastoma (iMB) is usually treated without craniospinal irradiation (CSI) to avoid neurocognitive late effects. Unfortunately, many children relapse. The purpose of this study was assess salvage strategies prognostic features patients with iMB who relapse after CSI-sparing therapy.
Health-related comorbidities often increase due to cancer among the ageing population. However, thed omains of psychological functioning geriatric patients remain undetected especially in Indian scenario. This study aimed evaluate problems, perceived social support, fatigue, and quality life with cancer.A cross sectional was conducted a tertiary center. Geriatric (n = 130) having solid malignancies categorized as older (>65 years) younger (60-65 were included study. Depression, anxiety,...
Introduction Advancements in genomic profiling led to the discovery of four major molecular subgroups medulloblastoma (MB), which have now been incorporated into World Health Organization classification central nervous system tumors. The current study aimed determine prognostic significance MB among children Malaysia. Methods We assembled samples from <18 years between January 2003 and June 2017 pediatric oncology centers was sub-grouped using 850k DNA methylation testing at German...
Abstract The initial signs of hepatic sinusoidal obstruction syndrome (HSOS) can be challenging to recognize in children, especially outside the hematopoietic stem cell transplantation setting. To assist clinicians promptly identify HSOS, European Society for Blood and Marrow Transplantation has proposed pediatric HSOS diagnostic criteria which emphasize unexplained consumptive transfusion‐refractory thrombocytopenia. highlight importance these “bellwether” early efficacy pre‐emptive...
Aim Inborn errors of immunity (IEI) comprise a heterogeneous group disorders the immune system, most which are curable by haematopoietic stem cell transplantation (HSCT). We present 25‐year audit HSCT for IEI at tertiary‐level academic hospital in Malaysia. Methods Review medical records all cases who underwent between January 1993 and December 2018 our centre. Diagnoses, complications, protocols outcome data were studied. Results There 20 patients (19 boys) with median age diagnosis 11...
Microvascular endothelial dysfunction is central to the pathogenesis of cardiovascular disease (CVD). The eye offers direct access for health assessment via retinal microvasculature. aim study was investigate whether image-based vessel analysis a feasible method assessing in survivors childhood acute lymphoblastic leukemia (cALL).Cardiovascular risk factors (CRFs) were estimated using 30-year Framingham Risk Score 73 (median age: 25; median years from diagnosis: 19) and 78 healthy controls...
Pediatric central nervous system tumor survivors (CNSTS) experience late effects that may affect their health-related quality of life (HRQOL). The study aims: i) compare HRQOL among Malaysian CNSTS with acute lymphoblastic leukemia (ALLS) and healthy children, ii) explore factors associated low HRQOL. We performed a comparative cross-sectional 46 aged 5-18 years 90 ALLS (age gender-matched) who completed treatment for >1 year, published cohort children. Quality Life Inventory (PedsQL) was...
The International Society of Thrombosis and Hemostasis (ISTH) provides objective disseminated intravascular coagulation (DIC) measurement through diagnostic criteria validated in adults. applicability these pediatric neonatal DIC is controversial unvalidated. Primary objective: to evaluate current practice management among different specialties. Secondary understand the potential impact developmental hemostasis on laboratory evaluation. We performed a multicenter survey between January...