A5044812818- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Amino Acid Enzymes and Metabolism
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Gut microbiota and health
- Head and Neck Cancer Studies
- Chronic Disease Management Strategies
- COVID-19 Clinical Research Studies
- Oral health in cancer treatment
- Global Cancer Incidence and Screening
- Retinal Diseases and Treatments
- Childhood Cancer Survivors' Quality of Life
- Adolescent Sexual and Reproductive Health
- Lipoproteins and Cardiovascular Health
- Drug-Induced Adverse Reactions
University of Malaya
2016-2025
Hospital Universiti Sains Malaysia
2023
Kyushu University
2023
The University of Melbourne
2012-2023
Peter Doherty Institute
2016-2023
Evidence (Italy)
2021
Zero to Three
2020
Burnet Institute
2011-2014
Monash University
2010-2014
University Malaya Medical Centre
2014
FcRγ is an ITAM-containing adaptor required for CD16 signaling and function in NK cells. We have previously shown that cells from HIV patients receiving combination antiretroviral therapy (cART) decreased expression, but the factors causing this are unknown. conducted a cross-sectional study of cART-naive viremic (ART(-)), virologically suppressed cART (ART(+)), HIV-uninfected controls. CD8(+) T were activated, as assessed by CD38(+)HLA-DR(+) ART(-) (p < 0.0001), which was significantly...
Polypharmacy has been associated with increased morbidity and mortality in the older population.The aim of this study was to determine prevalence, risk factors health outcomes polypharmacy a cohort urban community-dwelling adults receiving chronic medications Malaysia.This baseline Malaysian Elders Longitudinal Research cohort. The inclusion criteria were individuals aged ≥55years taking at least one medication chronically (≥3 months). Participants interviewed using structured questionnaire...
Multiple host factors may influence CD4(+) T cell reconstitution in human immunodeficiency virus (HIV)-infected patients after suppressive antiretroviral therapy (ART). We hypothesized that residual immune activation and polymorphisms the interleukin 7 (IL-7) receptor α (IL-7Rα) gene were important for recovery.We examined HIV-infected receiving ART (n = 96) their IL-7Rα haplotypes measured levels of lipopolysaccharide (LPS), soluble CD14, IL-7 plasma samples collected before initiation....
Most patients with human immunodeficiency virus (HIV) who remain CD4+ T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors in HIV good poor recovery long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased T cells of recovery, whereas did not differ from those healthy controls. Poor was also associated expression markers...
Introduction The availability of combination antiretroviral therapy (cART) has led to substantial reduction in morbidity and mortality HIV-infected patients; however, life expectancy remains reduced especially patients who initiate cART with CD4 T-cell counts less than 200 cells/μl [1]. Increased immune activation on long-term suppressive [2–4] been associated increased [5,6] both AIDS non-AIDS-defining illnesses [7–10], suggesting that chronic may have a potential role driving mortality....
We explored the gut microbiota profile among HIV-infected individuals with diverse immune recovery profiles following long-term suppressive ART and investigated relationship between altered bacteria markers of dysfunction. The rectal swabs from 26 20 HIV-uninfected controls were examined. Patients classified as suboptimal responders, sIR (n = 10, CD4 T-cell <350 cells/ul) optimal oIR 16, >500 after a minimum 2 years on ART. Canonical correlation analysis(CCA) multiple regression modelling...
Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation therapy. These late effects include chronic inflammation-related comorbidities obesity and type 2 diabetes, but the underlying cause is poorly understood. We compared anal microbiota composition adult ALL (N = 73) with healthy control subjects 61). identified an altered community reduced microbial diversity in cancer survivors, who also exhibit...
Abstract Background Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether perturbed community is restored after disease remission cessation cancer treatment not evaluated. This study examines chronological changes children acute lymphoblastic (ALL) prior to start-, during-, following Methodology We conducted a longitudinal observational profile group paediatric patients diagnosed ALL using 16 s ribosomal RNA sequencing compared...
Abstract Studies in vivo have demonstrated that the accumulation of d -amino acids ( -AAs) is associated with age-related diseases and increased immune activation. However, underlying mechanism(s) these observations are not well defined. The metabolism -AAs by oxidase (DAO) produces hydrogen peroxide (H 2 O ), a reactive oxygen species involved several physiological processes including response, cell differentiation, proliferation. Excessive levels H contribute to oxidative stress eventual...
ABSTRACT We developed a real-time PCR to quantify 16S rRNA gene levels in plasma from HIV-infected patients as marker of microbial translocation. The assay uses shrimp nuclease (SNuc) eliminate DNA contamination, giving high sensitivity and low variability. measured HIV correlated significantly with lipopolysaccharide levels.
Repetitive stimulation by persistent pathogens such as HCMV or HIV induces the differentiation of NK cells. This maturation pathway is characterized acquisition phenotypic markers, CD2, CD57 and NKG2C, effector functions – a process regulated Tim-3 orchestrated complex network transcriptional factors, involving T-bet, Eomes, Zeb2, PLZF, Foxo3. Here, we show that immune activation during chronic viral co-infections (HCMV, HCV, HIV) interferes with functional phenotype cells modulating...
The diversity of the naïve T cell repertoire drives replenishment potential and capacity memory cells to respond immune challenges. Attrition system is associated with an increased prevalence pathologies in aged individuals, but whether stem lymphocytes (T
Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge; however, studies assessing multidimensional aspects of aging are lacking. We characterized 10 geriatric conditions encompassing multiple functional domains, its health impact and associated risk factors in age-matched uninfected controls.HIV-infected were recruited from the outpatient clinic University Malaya Medical Centre, Malaysia controls community. All participants aged at least 25...
Objectives: In a clinic-based, treated HIV-infected cohort, we identified individuals with sarcopenia and compared age, sex ethnically matched controls; investigated associated risk factors health outcomes. Design: Sarcopenia (age-related muscle loss) causes significant morbidity to the elderly, leading frequent hospitalizations, disability death. Few have characterized in who experience accelerated aging. Methods: was defined as low mass weak grip strength and/or slow gait speed using lower...
A small but significant number of patients do not achieve CD4 T-cell counts >500 cells/µl despite years suppressive cART. These remain at risk AIDS and non-AIDS defining illnesses. The aim this study was to identify clinical factors associated with recovery following long-term cART.Patients the inclusion criteria were selected from Australian HIV Observational Database (AHOD): cART as their first regimen initiated count <500 cells/µl, RNA<500 copies/ml after 6 months sustained for least 12...