A5023231822- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- Diabetes and associated disorders
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- HIV/AIDS Research and Interventions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Helminth infection and control
- Peripheral Neuropathies and Disorders
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
University of Indonesia
2015-2025
Curtin University
2016-2025
University of the Witwatersrand
2013-2023
Bentley (Germany)
2021
The University of Western Australia
2008-2017
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2009-2016
Royal Perth Hospital
2003-2015
The Alfred Hospital
2009
Burnet Institute
2009
Australian National University
2009
Background To determine if infectious disease events in HIV‐infected patients treated with highly active antiretroviral therapy (HAART) are a consequence of the restoration pathogen‐specific immune responses, single‐centre retrospective study all commencing HAART prior to 1 July 1997 was undertaken incidence, characteristics and time onset episodes responders (decrease plasma HIV RNA > log 10 copies/mL). Methods Baseline post‐therapy changes CD4 T‐cell counts were compared without...
IN 1966 Davis et al.1 described two girls with chronic eczema, recurrent staphylococcal infections and an abnormal inflammatory response the formation of "cold" abscesses (Job's syndrome). Buckley al.2 observed hyperimmunoglobulinemia E in boys severe skin lung infections, Clark al.3 demonstrated depressed chemotaxis polymorphonuclear leukocytes a girl similar clinical manifestations. Subsequently, Hill al.4 reported defective original cases Job's syndrome. Several other patients related...
Objective: To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms. Design: DNA samples from a range were typed for polymorphic loci genes encoding immune-mediators. Methods: PCR–restriction fragment length polymorphism assays used type IL1A, IL1B, IL6, TNFA IL12B genes. Alleles microsatellite...
To examine the relationships between blood CD4 natural regulatory T (Treg) cells, plasma HIV RNA level, T-cell count and immune activation in untreated HIV-infected patients immunodeficient beginning antiretroviral therapy (ART), using a novel phenotype to define Treg cells (CD25CD127CD4). Data were compared with established cell markers (FoxP3, CTLA-4 GITR).Twenty-nine counts of < 300 or > 400/microl cross-sectional study 12 combination ART 100 cells/mul followed for 1 year on therapy....
The aim of the study was to describe prevalence and risk factors for HIV-associated sensory neuropathy (HIV-SN) in 2006 [the era stavudine, didanosine zalcitabine (dNRTI)-sparing highly active antiretroviral therapy (HAART)] compare our findings with data obtained same clinic 1993 (pre-HAART) 2001 (frequent use dNRTI-containing HAART).This a cross-sectional comparative using convenience sampling. HIV-positive adults attending tertiary referral over 2-week period were screened HIV-SN AIDS...
Most patients with human immunodeficiency virus (HIV) who remain CD4+ T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors in HIV good poor recovery long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased T cells of recovery, whereas did not differ from those healthy controls. Poor was also associated expression markers...
Enhanced tumor cell survival through expression of inhibitors apoptosis (IAP) is a hallmark cancer. Survivin, an IAP absent from most normal tissues, overexpressed in many malignancies and associated with poorer prognosis. We report the first-in-human dose study LY2181308, second-generation antisense oligonucleotide (ASO) directed against survivin mRNA.A dose-escalation evaluating safety, pharmacokinetics, pharmacodynamics LY2181308 administered intravenously for 3 hours as loading on...
Sensory neuropathy is a common problem in HIV-infected patients and the dose-limiting toxicity of stavudine. Affordable methods predicting risk are needed to guide prescribing countries where some use stavudine remains an economic necessity. We therefore aimed identify factors predictive before antiretroviral use.A total 294 attending clinics Melbourne, Kuala Lumpur, Jakarta were enrolled cross-sectional screening program 2006. Neuropathy was defined by presence symptoms signs on AIDS...
Factors which increase the risk of severe adult periodontitis (AP) may also contribute to success dental implants. To determine cytokines be relevant, levels interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-gamma (IFN-gamma) mRNA were quantitated in gingival tissue from patients healthy controls. Periodontitis significantly increased IL-1alpha, IL-1beta, IL-6 IFN-gamma relative tissues. IL-1 was...
Objectives We have previously described immune restoration diseases (IRD) associated with asymptomatic opportunistic infections presenting in immunodeficient HIV patients responding to highly active antiretroviral therapy (HAART). Here we address the question of whether a history IRD exhibit persistent activation, shown by elevated levels interleukin‐(IL)‐6 and soluble IL‐6 receptor (sIL‐6R). Methods Peripheral blood mononuclear cells (PBMCs) plasma were collected from nadir CD4 T cell...
Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles HIV-associated neurocognitive disorder (HAND) remains unclear. Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% 60+; median duration 20 years, >95% plasma CSF RNA <50 cp/mL, on cART for 24 months). All underwent standard neuropsychological testing (61% had HAND), APOE genotyping (30.9% carried ε4 7.1% homozygotes) lumbar...
Plasma levels of cytomegalovirus (CMV)-specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor-I (TNFR-I) were assessed in human immunodeficiency virus (HIV)-infected patients who experienced CMV retinitis (CMVR) as an immune restoration disease (IRD) during their first 6 months highly active antiretroviral therapy (HAART) CMV-seropositive, HIV-infected with similar baseline CD4+ T cell counts had...
Previous studies of sporadic inclusion body myositis (sIBM) have shown a strong association with HLA-DR3 and other components the 8.1 ancestral haplotype (AH) (HLA-A1, B8, DR3), where susceptibility locus has been mapped to central major histocompatibility complex (MHC) region between HLA-DR C4. Here, genes in MHC class II was further investigated group 42 sIBM patients an ethnically similar control (n = 214), using single-nucleotide polymorphisms microsatellite screening. (marking DRB1*0301...
A toxic sensory neuropathy associated with exposure to inexpensive nucleoside analogue reverse transcriptase inhibitors (NRTIs) [particularly stavudine (d4T)] causes dilemmas in the management of patients HIV, especially resource-poor settings. Here (n = 96) attending Pokdisus AIDS Clinic at Cipto Mangunkusumo Hospital, Jakarta who had been treated d4T were screened for symptomatic neuropathy. Clinical, demographic, and genetic factors considered as possible risk factors. DNA from saliva was...