A5086716031- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Syphilis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Mosquito-borne diseases and control
- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Bacterial Infections and Vaccines
- Herpesvirus Infections and Treatments
- Plant Virus Research Studies
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Restless Legs Syndrome Research
- Full-Duplex Wireless Communications
University of California, San Diego
2023-2025
Neurobehavioral Research (United States)
2023-2025
Ospedale Amedeo di Savoia
2016-2024
University of Turin
2016-2024
University of Gothenburg
2021
Sapienza University of Rome
2021
Ospedale Maria Vittoria
2021
University of Modena and Reggio Emilia
2021
ASL Roma
2020
University of Milan
2014-2019
To date, there is no severe acute respiratory syndrome coronavirus 2-(SARS-CoV-2)-specific prognostic biomarker available. We assessed whether SARS-CoV-2 cycle threshold (Ct) value at diagnosis could predict novel CoronaVirus Disease 2019 (COVID-19) severity, clinical manifestations, and six-month sequelae. Hospitalized outpatient cases were randomly sampled from the diagnoses of March 2020 data collected 6 months by interview regional database for COVID-19 emergency. Patients stratified...
SARS-CoV-2 can produce both severe clinical conditions and long-term sequelae, but data describing post-acute COVID-19 syndrome (PACS) are lacking for people living with HIV (PLWH). We aimed at assessing the prevalence factors associated PACS in our cohort. included all unvaccinated adult PLWH on antiretroviral treatment plasma HIV-RNA < 40 cp/mL since least six months before infection Infectious Tropical Diseases Unit of Padua (Italy), from 20 February 2020 to 31 March 2021. severity was...
Recently, a benefit from administration of 3-day course early remdesivir (ER) in the outpatients' setting was reported. However, real-life data on its use is scarce. Therefore, we explored ER clinical outcome our s cohort, compared to untreated controls. We included all patients who were prescribed February May 2022 and followed them up for 3 months received treatment with In two groups following outcomes investigated: hospitalization mortality rate, time negativization symptom's resolution,...
Background: The relationship between sleep disorders (SDs), cardiovascular risk (CVR), and mood (MDs) has been studied in detail the general population, but far less people with HIV (PWH). Methods: Cross-sectional analysis single centre cohort of PWH. Sleep quality was assessed using by Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), Berlin Questionnaire (BQ), Pittsburgh Quality (PSQI); anxiety depression were evaluated Generalized Anxiety Disorder-7 Patient Health...
COVID-19 is characterized by an uncontrolled inflammatory response with high pro-inflammatory cytokine production through the activation of intracellular pathways, such as mitogen-activated protein kinase (MAPK). Viruses are able to exploit MAPK pathway their advantage; this relevance severe poorly described. The aim study was quantify biomarkers involved in and clarify its possible role affecting some COVID-19-related clinical features.H-RAS, C-RAF, MAPK1, MAPK2, ERK were quantified ELISA,...
Abstract We measured severe acute respiratory syndrome coronavirus 2 spike protein subunits S1/S2 antibodies by using capillary electrophoresis and a chemiluminescence immunoassay for 5,444 active healthcare workers in Italy. Seroprevalence was 6.9% higher among participants having contact with patients. Seroconversion not observed 37/213 previously infected participants.
Psoriatic patients with latent tuberculosis infection and properly treated active need careful management when prescribing modern biological drugs. Although data guidelines regarding tumour necrosis factor-α inhibitors advise caution initiation of prophylactic therapy in infection, the same indications do not seem to find equal force for interleukin (IL)-23 IL-17 inhibitors. In order evaluate risk reactivation or tuberculosis, an observational retrospective study was conducted on population...
The aim of this large multicenter study was to determine variations in cerebrospinal fluid (CSF) HIV-RNA different phases untreated human immunodeficiency virus type 1 (HIV-1) infection and its associations with plasma other biomarkers.Treatment naive adults available CSF quantification were included divided into groups representing significant disease phases. Plasma HIV-RNA, white blood cell count (WBC), neopterin, albumin ratio when available.In total, 1018 patients included. median...
Background: Clinical trials and real-life studies have granted the efficacy safety of dolutegravir lamivudine (DTG/3TC) in naïve experienced people living with HIV (PLWH), but there are no long-term data elderly people. We herein describe our cohort PLWH who were ≥65 years age (PLWH ≥ 65) started or switched to DTG/3TC, single-tablet regimen, DTG plus 3TC. Methods: considered laboratory/clinical parameter changes from baseline last follow-up time point available for each person by paired...
Despite effective HIV suppression, neuroinflammation and neurocognitive issues are prevalent in people with (PWH) yet poorly understood. infection alters the human virome, virome perturbations have been linked to without HIV. Once thought be sterile, cerebrospinal fluid (CSF) hosts a recently discovered presenting an unexplored avenue for understanding brain mental health PWH. This cross-sectional study analyzed 85 CSF samples (74 from PWH on suppressive antiretroviral therapy, 11 controls...
Antiretroviral therapy (ART) drugs vary in their distribution into cerebrospinal fluid (CSF), which can be estimated using the central nervous system (CNS) penetration effectiveness (CPE) score. Although higher CPE has been associated with lower CSF HIV RNA levels, its relationship to inflammation is less clear. We investigated associations between and three immune biomarkers (CXCL10, TNF-α, IL-6) 275 virally suppressed people (PWH) on three-drug ART regimens a training–validation design....
Despite the substantial changes resulting from introduction of combination antiretroviral therapy (cART), prevalence HIV-associated neurocognitive disorders (HAND) remains substantial. Blood–brain barrier impairment (BBBi) is a frequent feature in people living with HIV (PLWH) and it may persist despite effective treatment. A cross-sectional study was performed PLWH who underwent lumbar puncture for clinical reasons or research protocols several cerebrospinal fluid biomarkers were studied....
Identifying determinants of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission in settings contagion is fundamental to inform containment strategies. We assessed SARS-CoV-2 cycle threshold value (Ct) from first diagnostic nasal-pharyngeal swab symptomatic index cases and which demographic or clinical characteristics among contacts are associated with risk within households.This a retrospective prevalence study on secondary (SC) household adult randomly...