A5103031521- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Myasthenia Gravis and Thymoma
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer survivorship and care
- Mitochondrial Function and Pathology
- Cannabis and Cannabinoid Research
- Hormonal Regulation and Hypertension
- HIV/AIDS drug development and treatment
- Tracheal and airway disorders
- Cardiac tumors and thrombi
- Chronic Myeloid Leukemia Treatments
- Sex and Gender in Healthcare
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Venomous Animal Envenomation and Studies
- Forensic Toxicology and Drug Analysis
- Antifungal resistance and susceptibility
University of Turin
2021-2025
Ospedale San Luigi Gonzaga
2021-2025
University of Trento
2025
University of Oxford
2021-2023
National Health Service
2021-2023
John Radcliffe Hospital
2022-2023
Oxford University Hospitals NHS Trust
2018-2022
AstraZeneca (Brazil)
2020
University of Birmingham
2020
Stryker (United Kingdom)
2020
Abstract Purpose: Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial determine whether the antimalarial drug atovaquone, known mitochondrial inhibitor, reduces in non–small cell lung cancer (NSCLC). Patients Methods: with NSCLC scheduled for surgery were recruited sequentially into two cohorts: cohort 1 received oral atovaquone at standard dose of 750 mg twice daily, while 2 did not. Primary imaging endpoint was...
Therapeutic drug monitoring (TDM) for antibiotic drugs represents a consolidated practice to optimize the effectiveness and limit toxicity of specific by guiding dosage adjustments. The comparison TDM results with drug-specific pharmacokinetic/pharmacodynamic (PK/PD) parameters, based on killing dynamics bacterial susceptibility, increases probability therapeutic success.The aim this study was analytical validation new UHPLC-MS/MS assay quantification 19 antibiotics divided in two different...
Background: The use of herbs to treat illnesses was common in all historical eras. Our aim describe the phytotherapeutic substances that cancer patients most commonly, and determine whether their can increase side effects. Methods: This a retrospective descriptive study conducted among older adults actively undergoing chemotherapy, admitted at Oncology DH Unit (COES) Molinette Hospital AOU Città della Salute e Scienza Turin (Italy). Data collection through distribution self-compiled...
COVID-19 is characterized by an uncontrolled inflammatory response with high pro-inflammatory cytokine production through the activation of intracellular pathways, such as mitogen-activated protein kinase (MAPK). Viruses are able to exploit MAPK pathway their advantage; this relevance severe poorly described. The aim study was quantify biomarkers involved in and clarify its possible role affecting some COVID-19-related clinical features.H-RAS, C-RAF, MAPK1, MAPK2, ERK were quantified ELISA,...
High levels of reactive oxygen species (ROS) are present in people living with HIV (PLWH), produced by intense physical activity; response, our body produces antioxidant molecules. ROS influence the expression gene-encoding enzymes and transporters involved drug biotransformation. In addition, pharmacogenetics can transporter activity, thus exposure. Currently, no studies concerning this topic literature. The aim study was to investigate whether some molecules, exercise, genetic variants...
Bilateral trigeminal neuralgia refractory to medical therapy is a rare occurrence and it mandatory choose therapeutic procedures minimizing possible bilateral sensitive deficit due the employment of mininvasive ablative techniques. A patient affected by secondary multiple sclerosis presented. Multiple tools were employed in this challenging pathology. The second third left divisions involved neuralgia, while division was right facial side. Controlled radiofrequency thermocoagulation for...
Endometriosis afflicts 10% of women in their reproductive years and nearly half with infertility, its etiology is not yet clear. Pharmacological therapy generally based on progestins like progestogen. This drug binds to progesterone receptors many known side effects. Here, we describe the case a 33-year-old woman surgically treated for endometriosis who continued estradiol valerate dienogest. Approximately 21 months after treatment, she reported ocular symptoms vision alteration, diplopia,...
Background: Glyphosate has been extensively used as herbicide since the early 1970s. The daily exposure limit is set at 0.3 mg/kg bw/d in Europe and 1.75 USA. Among its derivatives, aminomethylphosphonic acid most stable abundant. Understanding their biological effects then requires reliable methods for quantification samples. Methods: We developed validated a fast, low-cost, chromatographic method determining glyphosate concentrations. validation included following parameters: specificity,...
Cannabis sativa L. shows potent anti-inflammatory activity, resulting in an interesting pharmacological option for pain management. The aim of the study was to evaluate association between pharmacogenetics, neurological and inflammatory biomarkers, cannabinoid plasma exposure patients treated with cannabis. A total 58 a diagnosis neuropathic chronic medical cannabis were analyzed. administered as decoction (n = 47) inhaled 11): 30 high THC, while 28 reduced THC (plus CBD). Cannabinoid...
Background: Urinary steroid profiling plays a key role in the diagnosis of inherited and acquired endocrine disorders. Despite proven diagnostic value gas chromatography–mass spectrometry (GC-MS), standardized clinically validated protocols for extended panels remain limited. Methods: We developed GC-MS method quantification 32 urinary metabolites, including androgens, estrogens, progestins, glucocorticoids, mineralocorticoids. Sample preparation involved solid-phase extraction, enzymatic...
Context. Some clinical aspects about neurotoxicity after snakebites by European viper species remain to be elucidated. Objective. This observational case series aims analyze neurological manifestations due envenomation in Italy order describe the characteristic of and evaluate response antidotic treatment, outcome, influence individual variability determining appearance neurotoxic effects. Materials methods. All cases snakebite referred Pavia Poison Centre (PPC) presenting peripheral effects...
Objective After the introduction of video-assisted thoracoscopic surgery 20 years ago, minimally invasive techniques in thoracic have found a growing application. The recent robotic technology has increased potentiality technique leading to an expansion indications and applications, particularly for management mediastinal diseases. We reviewed our experience robot-assisted resection benign malignant Methods Between 2002 2010, 108 patients (79 women 29 men; median age 38 y) underwent...
Cannabinoid derivates have been largely used for different medical purpose. In the literature, several methods capable of separating THC and its principles metabolites are described, although Δ8- Δ9-THC separation has not completely achieved. metabolism fully understood plasma distribution in healthy pathological patients remains to further deepen. The aim this study was validation UHPLC-MS/MS method quantification 10 cannabinoids human plasma, as important tool improving clinical efficacy...
Background: Physical activity could increase the production of oxidative stress biomarkers, affecting metabolism and excretion antiretroviral drugs and, consequently, clinical outcome. Nowadays, people living with HIV (PLWH) are mostly switching from triple to dual therapy, but no data available in terms physical functioning stress. The aim this study was evaluate if some antioxidant biomarkers tests be different according or therapy. Methods: PLWH were evaluated at baseline (BL), while...
The phytocomplex of Cannabis is made up approximately 500 substances: terpeno-phenols metabolites, including Δ-9-tetrahydrocannabinol and cannabidiol, exhibit pharmacological activity. Medical has several potential applications, in particular the management chronic neuropathic pain. In literature, a few data are available concerning cannabis pharmacokinetics, efficacy safety. Thus, aim present study was evaluation cannabinoid pharmacokinetics cohort patients, with pain, treated inhaled...