A5006896785- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- HIV/AIDS drug development and treatment
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- CAR-T cell therapy research
- Bacillus and Francisella bacterial research
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Blood groups and transfusion
- HIV-related health complications and treatments
UNSW Sydney
2016-2025
The George Institute for Global Health
2024
Swansea University
2024
The University of Sydney
1992-2023
Institute of Infection and Immunity
2021
GTx (United States)
2005-2015
Prince of Wales Hospital
2004-2014
The University of Melbourne
2005-2014
Peter Doherty Institute
2014
National Institutes of Health
2009
Abstract The emergence of the SARS-CoV-2 variant concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness lead to re-infections 1 . Here we investigated escape from neutralization by antibodies African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination who were previously infected or no evidence previous infection. isolated sequence-confirmed live virus an person observed that...
Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection...
The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we show a comprehensive profile antibody, B cell T dynamics over time in cohort patients who have recovered from mild-moderate COVID-19. Binding neutralising antibody responses, together with individual serum clonotypes, decay the first 4 months post-infection. A similar decline Spike-specific CD4+ circulating follicular helper frequencies occurs. By contrast,...
The emergence of SARS-CoV-2 Omicron, first identified in Botswana and South Africa, may compromise vaccine effectiveness the ability antibodies triggered by previous infection to protect against re-infection (1). Here we investigated whether Omicron escapes antibody neutralization Africans, either previously infected or uninfected, who were vaccinated with Pfizer BNT162b2. We also if requires ACE2 receptor infect cells. isolated sequence confirmed live virus from an person Africa compared...
Catalytic DNA molecules that target the transcription factor c- jun inhibit skin cancer growth in mice.
The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes all lineages, including population known as mucosal-associated invariant (MAIT) cells. To understand whether different cell subsets expressing have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. analysis identified conserved CD161++/MAIT transcriptional signature enriched CD161+CD8+ cells, which can be extended to CD161+ CD4+ CD161+TCRγδ+...
Significance Neutralizing antibodies are important for immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as therapeutics the prevention treatment of COVID-19. We identified high-affinity nanobodies SARS-CoV-2 receptor-binding domain found that nanobody cocktails consisting two noncompeting were able to block ACE2 engagement with RBD variants present in human populations potently neutralize both wild-type N501Y D614G variant at low concentrations. Prophylactic...
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and estimated the relationship between antibodies protection. However, results of these vary in terms estimates level required for By normalizing titers, we found study converge on a consistent COVID-19. This finding can be useful planning future vaccine use, determining population immunity, reducing global effects pandemic.
Human infection challenge permits in-depth, early, and pre-symptomatic characterization of the immune response, enabling identification factors that are important for viral clearance. Here, we performed intranasal inoculation 34 young adult, seronegative volunteers with a pre-Alpha severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain. Of these participants, 18 (53%) became infected showed an interferon-dominated mediator response divergent kinetics between nasal systemic...
The human naive T cell repertoire is the repository of a vast array TCRs. However, factors that shape their hierarchical distribution and relationship with memory remain poorly understood. In this study, we used polychromatic flow cytometry to isolate highly pure CD8(+) cells, stringently defined multiple phenotypic markers, deep sequencing characterize corresponding portions respective TCR repertoires from four individuals. extent interindividual sharing overlap between compartments within...
Public responses where identical T cell receptors (TCRs) are clonally dominant and shared between different individuals a common characteristic of CD8 + cell-mediated immunity. Focusing on TCR sharing, we analyzed ≈3,400 β chains (TCRβs) from mouse cells responding to the influenza A virus D b NP 366 PA 224 epitopes. Both “public” -specific “private” repertoires contain high proportion (≈36%) TCRβs, although numbers mice sharing TCRβs in each repertoire varies greatly. Sharing both TCRβ...