Christopher M. McAllister
A5017521854- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- SARS-CoV-2 detection and testing
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- Electron and X-Ray Spectroscopy Techniques
- Infection Control and Ventilation
- Pregnancy and Medication Impact
- Health Literacy and Information Accessibility
- Biochemical Analysis and Sensing Techniques
- Catalysis and Oxidation Reactions
- Genetics and Physical Performance
- Lymphoma Diagnosis and Treatment
- Mobile Health and mHealth Applications
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Cardiomyopathy and Myosin Studies
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
University of Pennsylvania
2020-2024
Long Island University
2022
Philadelphia University
2022
Czech Academy of Sciences, Institute of Microbiology
2021
Toronto Public Health
2017
National Fire Protection Association
1923-1926
National Research Council
1926
National Safety Council
1926
Advisory Board Company (United States)
1926
Conference Board
1924
Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection...
Novel mRNA vaccines for SARS-CoV-2 have been authorized emergency use. Despite their efficacy in clinical trials, data on vaccine-induced immune responses are mostly limited to serological analyses. Here, we interrogated antibody and antigen-specific memory B cells over time 33 naïve 11 recovered subjects. individuals required both vaccine doses optimal increases antibodies, particularly neutralizing titers against the B.1.351 variant. Memory specific full-length spike protein receptor...
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients who were hospitalized for COVID-19, hematologic had higher relative to solid cancer. two additional cohorts, flow cytometric serologic analyses demonstrated without similar phenotype during acute whereas impairment B cells severe respiratory syndrome 2 (SARS-CoV-2)-specific antibody responses. Despite impaired...
<h3>Importance</h3> Maternally derived antibodies are a key element of neonatal immunity. Understanding the dynamics maternal antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental transfer can inform management as well vaccination strategies. <h3>Objective</h3> To assess association between SARS-CoV-2–specific concentrations. <h3>Design, Setting, Participants</h3> This cohort study took place at...
ABSTRACT SARS-CoV-2 mRNA vaccines have shown remarkable efficacy, especially in preventing severe illness and hospitalization. However, the emergence of several variants concern reports declining antibody levels raised uncertainty about durability immune memory following vaccination. In this study, we longitudinally profiled both cellular responses naïve recovered individuals from pre-vaccine baseline to 6 months post-mRNA Antibody neutralizing titers decayed peak but remained detectable all...
SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal coronaviruses (hCoVs) before COVID-19 pandemic. Here, we quantified levels of SARS-CoV-2-reactive antibodies and hCoV-reactive in serum samples collected from 204 We then pre-pandemic antibody separate cohort 252 individuals who became...
ABSTRACT Novel mRNA vaccines for SARS-CoV2 have been authorized emergency use and are currently being administered to millions of individuals worldwide. Despite their efficacy in clinical trials, there is limited data on vaccine-induced immune responses with a prior infection compared naïve subjects. Moreover, how impact the development antibodies as well memory B cells COVID-19 experienced versus subjects remains poorly understood. In this study, we evaluated antibody antigen-specific cell...
Importance Pregnant persons are at an increased risk of severe COVID-19 from SARS-CoV-2 infection, and vaccination is currently recommended during pregnancy. Objective To ascertain the association vaccine type, time vaccination, gestational age delivery, pregnancy complications with placental transfer antibodies to SARS-CoV-2. Design, Setting, Participants This cohort study was conducted in Pennsylvania Hospital Philadelphia, Pennsylvania, included births site between August 9, 2020, April...
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer hospitalized for COVID-19 at University Pennsylvania Health System, we found that with hematologic cancers had significantly higher relative to solid after accounting confounders including ECOG performance status active status. We performed flow cytometric serologic analyses 106 113 non-cancer controls two additional...
Summary The SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific analyses in healthy individuals following vaccination. Vaccination induced rapid near-maximal CD4 + responses all subjects after first vaccine dose. CD8 developed gradually second dose were variable. Vaccine-induced cells had central memory characteristics included both Tfh Th1 subsets, similar to...
Some studies suggest that recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection. We completed serological assays using samples collected from health care workers to identify antibody types protection and symptom duration. Rare cross-reactive antibodies elicited by past CCV were not protection; however, the duration of symptoms following was significantly in individuals higher betacoronavirus (βCoV) titers. Since titers decline over...
Abstract Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, the optimal timing vaccination relative therapy remains unknown. Severe acute respiratory syndrome coronavirus 2 vaccines created an opportunity for new insights in because patients were challenged a novel antigen across multiple phases treatment. We studied serologic messenger RNA response retrospective prospective cohorts lymphoma chronic lymphocytic leukemia, paired...
Abstract Voluntary or forced exercise training in mice is used to assess functional capacity as well potential disease‐modifying effects of over a range cardiovascular disease phenotypes. Compared voluntary wheel running, enables precise control workload and volume, results superior changes performance. However, the use shock grid with treadmill‐based associated stress risk injury, declining compliance longer periods time for many mouse strains. With these limitations mind, we designed...
Abstract Despite a clear role in protective immunity, the durability and quality of antibody memory B cell responses induced by mRNA vaccination, particularly 3 rd dose vaccine, remains unclear. Here, we examined cohort individuals sampled longitudinally for ∼9-10 months after primary 2-dose vaccine series, as well ∼3 dose. Notably, decay slowed significantly between 6- 9-months post-primary essentially stabilizing at time Antibody also continued to improve least 9 vaccination. Spike-...
(1) Background: Adverse effects of a chronic high-fat diet (HFD) on murine behavior, cognition, and memory are well established. Polyphenols such as resveratrol, anthocyanins, flavonoids, that known for antioxidative anti-inflammatory properties, present in grapes. The objective this work was to determine if the dietary intake grapes has potential alleviating HFD-induced deficiencies. (2) Methods: effect grape studied using behavioral assays high throughput genome-wide RNA transcriptome...
Abstract Recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection, however the immunological mechanisms involved unknown. We completed serological assays using samples collected from health care workers to identify antibody types protection and severity. Rare cross-reactive antibodies elicited by past CCV were not protection; however, duration of symptoms following was significantly in individuals higher betacoronavirus (βCoV) titers....
Abstract We measured SARS-CoV-2 antibody levels in serum samples from 1,471 mother/newborn dyads and found efficient transplacental transfer of IgG antibodies 72 83 seropositive pregnant women. Transfer ratios >1.0 were observed among women with an asymptomatic infection as well those mild, moderate severe COVID-19. Our findings demonstrate the potential for maternally-derived to provide neonatal protection infection.
Abstract Objective: To describe the cumulative seroprevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antibodies during disease 2019 (COVID-19) pandemic among employees a large pediatric healthcare system. Design, setting, and participants: Prospective observational cohort study open to adult at Children’s Hospital Philadelphia, conducted April 20–December 17, 2020. Methods: Employees were recruited starting with high-risk exposure groups, utilizing e-mails, flyers,...
Multiple studies have demonstrated the negative impact of cancer care delays during COVID-19 pandemic, and transmission mitigation techniques are imperative for continued delivery. We aimed to gauge effectiveness these measures at University Pennsylvania.
Abstract Multiple studies have demonstrated the negative impact of cancer care delays during COVID-19 pandemic, and transmission mitigation techniques are imperative for continued delivery. To gauge effectiveness these measures at University Pennsylvania, we conducted a longitudinal study SARS-CoV-2 antibody seropositivity seroconversion in patients presenting to infusion centers cancer-directed therapy between 5/21/2020 10/8/2020. Participants completed questionnaires had up five serial...