A5025539602- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Diabetes and associated disorders
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Photovoltaic System Optimization Techniques
- Tuberculosis Research and Epidemiology
- Solar Thermal and Photovoltaic Systems
- Natural Language Processing Techniques
- HIV Research and Treatment
- Pluripotent Stem Cells Research
- Immune responses and vaccinations
Stanford University
2016-2025
Howard Hughes Medical Institute
2016-2025
Palo Alto University
2004-2025
Skin Wellness Center
2025
Stratford University
2016-2024
Technological University Dublin
2024
Institute of Infection and Immunity
2014-2024
University of Pennsylvania
2024
Texas Oncology
2020-2024
Pfizer (United States)
2023-2024
Identification and characterization of antigen-specific T lymphocytes during the course an immune response is tedious indirect. To address this problem, peptide-major histocompatability complex (MHC) ligand for a given population cells was multimerized to make soluble peptide-MHC tetramers. Tetramers human lymphocyte antigen A2 that were complexed with two different immunodeficiency virus (HIV)-derived peptides or peptide derived from influenza A matrix protein bound peptide-specific...
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of central cluster cell receptors surrounded by ring adhesion molecules. Immunological synapse formation is now shown to be active dynamic mechanism that allows cells distinguish potential antigenic ligands. Initially, receptor ligands were engaged in outermost nascent synapse. Transport these complexes into was dependent on receptor–ligand interaction kinetics. Finally, stable...
To study the factors that determine whether CD4+ T cells produce interleukin 4 (IL-4) or interferon gamma (IFN-gamma) upon stimulation we used a system allowing naive to be primed in vitro by specific antigen. Dense were purified from mice expressed transgenes encoding cell receptor for pigeon cytochrome C peptide 88-104 association with I-Ek. These produced very limited amounts of IL-4 and IFN-gamma immediate challenge antigen-presenting (APC). However, after an initial "priming" culture...
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific...
<h3>Importance</h3> Food allergy is a costly, potentially life-threatening condition. Although studies have examined the prevalence of childhood food allergy, little known about prevalence, severity, or health care utilization related to allergies among US adults. <h3>Objective</h3> To provide nationally representative estimates distribution, and factors associated with adult allergies. <h3>Design, Setting, Participants</h3> In this cross-sectional survey study adults, surveys were...