A5101881641- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- Adolescent Sexual and Reproductive Health
- Immunotherapy and Immune Responses
- Reproductive Health and Contraception
- SARS-CoV-2 detection and testing
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Helicobacter pylori-related gastroenterology studies
- Molecular Biology Techniques and Applications
- Gastroesophageal reflux and treatments
- Childhood Cancer Survivors' Quality of Life
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- Global Maternal and Child Health
- Bacillus and Francisella bacterial research
- Cytomegalovirus and herpesvirus research
- Eosinophilic Esophagitis
- Chromatin Remodeling and Cancer
- T-cell and B-cell Immunology
The University of Melbourne
2019-2024
Peter Doherty Institute
2022-2024
Institute of Accelerating Systems and Applications
2022-2024
California State University, Long Beach
2024
Center for Global Health
2024
University of California, Davis
2024
University of California, Los Angeles
1991-2024
St. Joseph Medical Center
2024
University of North Carolina at Chapel Hill
2023-2024
Northern California Research
2024
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS limited. Because autoreactive CD4+ T cells and B as antigen-presenting are involved in pathogenesis, we characterized immunopeptidomes two allomorphs DR2a DR2b human primary monocytes, thymus, brain tissue. Self-peptides from HLA-DR molecules, particularly themselves, abundant on thymic cells. Furthermore, identified cell clones that can cross-react with...
Galectin-1, a β-galactoside binding protein, is produced by thymic epithelial cells and binds to human thymocytes. We have previously reported that galectin-1 induces the apoptosis of activated T lymphocytes. Because majority thymocytes die via while still within thymus, we tested whether could induce these cells. now report in vitro exposure induced two subsets CD4lo CD8lo The phenotypes susceptible were consistent with both negatively selected nonselected Galectin-1–induced was enhanced...
Abstract Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human murine thymocytes T cells. Galectin-1 binds to several glycoproteins on the cell surface, including CD7. However, surface glycoprotein receptors responsible for delivering galectin-1 signal have not been identified. We show that CD7 is required galectin-1-mediated death. This demonstrates a novel function as trigger identifies galectin-1/CD7 new biologic signaling pair.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation highly immune evasive and transmissible Omicron variants. Here, we report dynamics durability recalled spike-specific humoral immunity following BA.1 or BA.2 infection, longitudinal sampling up to 8 months after infection. Both infections robustly boosted neutralization activity against infecting strain while expanding breadth BA.4,...
Galectin-1 is an endogenous lectin expressed by thymic and lymph node stromal cells at sites of Ag presentation T cell death during normal development. It known to have immunomodulatory activity in vivo can induce apoptosis thymocytes activated (1-3). Here we demonstrate that galectin-1 stimulation cooperates with TCR engagement apoptosis, but antagonizes TCR-induced IL-2 production proliferation a murine hybridoma freshly isolated mouse thymocytes, respectively. Although CD4+ CD8+ double...
Abstract Galectin-1 induces death of immature thymocytes and activated T cells. binds to cell-surface glycoproteins CD45, CD43, CD7, although the precise roles each receptor in cell are unknown. We have determined that CD45 can positively negatively regulate galectin-1-induced death, depending on glycosylation status CD45+ BW5147 cells lacking core 2 β-1,6-N-acetylglucosaminyltransferase (C2GnT) were resistant galectin-1 death. The inhibitory effect C2GnT− appeared require cytoplasmic...
Abstract Galectin-1 kills immature thymocytes and activated peripheral T cells by binding to glycans on cell glycoproteins including CD7, CD45, CD43. Although roles for CD7 CD45 in regulating galectin-1-induced death have been described, the requirement CD43 remains unknown. We describe a novel role death, effects of O-glycan modification galectin-1 Loss expression reduced murine human lymphoblastoid cells, indicating that is required maximal susceptibility galectin-1. CD43, which heavily...
Lipid nanoparticle mRNA vaccines are an exciting but emerging technology used in humans. There is limited understanding of the factors that influence their biodistribution and immunogenicity. Antibodies to poly(ethylene glycol) (PEG), which on surface lipid nanoparticle, detectable humans boosted by human vaccination. We hypothesized PEG-specific antibodies could increase clearance vaccines. To test this, we developed methods quantify both vaccine ionizable frequent serial blood samples from...
BACKGROUNDThere is uncertainty about the timing of booster vaccination against COVID-19 in highly vaccinated populations during present endemic phase COVID-19. Studies focused on primary have previously suggested improved immunity with a longer interval between first and second vaccine doses.METHODSWe conducted randomized, controlled trial (November 2022-August 2023) assigned 52 fully adults to an immediate or 3-month delayed bivalent Spikevax mRNA vaccine. Follow-up visits were completed...
Abstract Background Antibiotic resistance is a well‐known factor of Helicobacter pylori eradication failure. Heteroresistance indicates the coexistence resistant and susceptible strains might lead to underestimating antimicrobial resistance. This study aims evaluate susceptibility profile, frequency heteroresistance H. strains, their effect on success in pediatric population. Materials Methods Children aged 2–17 years who underwent an upper gastrointestinal endoscopy from 2011 2019 with...
Significance NF1 is a monogenic disorder caused by mutations in the gene. While it affects multiple organs and tissues, how brain symptoms arise has been complicated to uncover. Since glial inhibitory neuron cells have implicated NF1, we conditionally deleted mouse Nf1 gene progenitors that give rise both of these cell types. We found were impacted when copies deleted, while properties specific group neurons altered either one or deleted. These data demonstrate phenotypes may contribute...
Urine CXCL10 (C-X-C motif chemokine ligand 10, interferon gamma-induced protein 10 [IP10]) outperforms standard-of-care monitoring for detecting subclinical and early clinical T-cell-mediated rejection (TCMR) may advance TCMR therapy development through biomarker-enriched trials. The goal was to perform an international multicenter validation of a bead-based immunoassay (Luminex) transplant surveillance compare with electrochemiluminescence-based (Meso Scale Discovery [MSD]) assay used in...
This pilot study assesses barriers to obtaining healthy affordable food and the early-stage acceptability of a novel subsidized frozen meal product designed address insecurity nutritional status among corner store customers in rural North Carolina. A convenience sample 50 were surveyed examine perceived availability options, maintaining diets, shopping consumption habits, reception product. Findings confirmed foods that seeks address, validity stores as intervention site, approval product's...
Mitogen-activated protein kinase phosphatase-1 (MKP-1) is one of several oxidized-l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC)-induced genes identified in human aortic endothelial cells (HAEC). We previously reported that MKP-1 activity required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an vivo role atherogenesis has not been investigated.We now report expressed the atherosclerotic lesions mice. mRNA expression highly induced C57BL6/J...
Carica papaya is a trioecious plant species with genetic sex-determination system defined by sex chromosomes. Under unfavorable environmental conditions male and hermaphrodite exhibit sex-reversal. Previous genomic research revealed few candidate genes for differentiation in this species. Nevertheless, more analysis still needed to identify the mechanism responsible flower organ development papaya.The aim of study was differentially expressed among male, female flowers during early...
Abstract Objectives To evaluate the efficacy and safety of a 10‐day quadruple therapy containing colloidal bismuth sub‐citrate (CBS), esomeprazole (ESO), amoxicillin (AMO), metronidazole (MET) for Helicobacter pylori ( H . ) eradication in children. Methods Monocentric, open‐label, prospective, single‐arm clinical trial children aged 6–17 years with infection. The study was carried out on consecutive patients upper gastrointestinal symptoms infection confirmed by histology culture gastric...
Lung cancer with brain metastasis has a high morbidity and mortality worldwide. Neurocysticercosis is parasitic infection commonly found in regions poor sanitation. We present case the coexistence of lung neurocysticercosis. A 57-year-old Caucasian female, history secondhand smoke exposure, presented cough. Further evaluation revealed lesion right upper lobe on CT scan, frontal MRI, hypermetabolic lymph nodes PET scan. Biopsies confirmed invasive moderately differentiated adenocarcinoma,...
Background Dual condom and long-acting reversible contraceptive (LARC) or non-LARC hormonal use is the most effective way to protect against unwanted pregnancy sexually transmissible infections (STIs). This study aimed determine whether varied between users of LARC contraceptives explore their motivations for use.Women aged 16-24 years attending a sexual reproductive health centre in Melbourne, Australia, completed survey about practices. The proportion using condoms was calculated logistic...
Abstract SARS-CoV-2 breakthrough infection of vaccinated individuals is increasingly common with the circulation highly immune evasive and transmissible Omicron variants. Here, we report dynamics durability recalled spike-specific humoral immunity following BA.1 or BA.2 infection, longitudinal sampling up to 8 months post-infection. Both robustly boosted neutralisation activity against infecting strain while expanding breadth other strains. Cross-reactive memory B cells both ancestral spike...
Palliative care in oncology provides multiple benefits, however access to specialty palliative clinicians is limited community cancer centers. Individual support services are more often available, but little known on the utilization and impact of these services.To describe outpatient advanced population association with ED hospital use a setting.A retrospective chart review 314 patients lung, gastrointestinal, genitourinary, gynecologic origin was conducted. Data collected included...
Young women in Australia disproportionately experience unintended pregnancy and sexually transmissible infections (STIs). As the promotion of highly effective prevention methods such as long-acting reversible contraception (LARC) increases, concurrent use condoms with LARC remains optimal for STI prevention. There is little data exploring condom behaviour young Australian using LARC. In this qualitative study we interviewed twenty about their experiences making decisions regarding use. We...