A5047098023- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Peripheral Neuropathies and Disorders
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Polyomavirus and related diseases
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Rheumatoid Arthritis Research and Therapies
- Chemokine receptors and signaling
- Autoimmune Neurological Disorders and Treatments
- Sleep and related disorders
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
University Hospital of Zurich
2015-2024
University of Zurich
2015-2024
Klinik Hirslanden
2024
University Children's Hospital Zurich
2024
GastroZentrum Hirslanden Zürich
2022
Universität Innsbruck
2002-2021
Medical University of Vienna
2015-2021
Innsbruck Medical University
2010-2021
Euroimmun Medizinische Labordiagnostika (Germany)
2021
Lindenhofspital
2021
Abstract Background Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO). However, AQP4-IgG absent in 5-40% of all NMO patients target autoimmune response these is unknown. Since recent studies indicate that responses to myelin oligodendrocyte glycoprotein (MOG) can induce an NMO-like disease experimental animal models, we speculate MOG might be autoantigen seronegative NMO. Although...
Multiple sclerosis is an autoimmune disease that caused by the interplay of genetic, particularly HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating autoreactive CD4+ T cell repertoire not clear. Here, we demonstrate self-reactivity, defined as "autoproliferation" peripheral Th1 cells, elevated in patients carrying haplotype. Autoproliferation mediated memory B cells a HLA-DR-dependent manner. Depletion vitro therapeutically vivo...
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune responses to EBV are associated with an increased risk of developing multiple sclerosis (MS). We explored mechanisms leading this change in EBV-specific immunity untreated patients MS healthy carriers matched for MS-associated HLA alleles. showed selective increase T cell the nuclear antigen 1 (EBNA1), most consistently recognized EBV-derived CD4+ carriers, but not other EBV-encoded proteins. In contrast,...
Antigen-coupled cells result in antigen-specific tolerization for treatment of multiple sclerosis.
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS limited. Because autoreactive CD4+ T cells and B as antigen-presenting are involved in pathogenesis, we characterized immunopeptidomes two allomorphs DR2a DR2b human primary monocytes, thymus, brain tissue. Self-peptides from HLA-DR molecules, particularly themselves, abundant on thymic cells. Furthermore, identified cell clones that can cross-react with...
Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antibodies pathogenic or an epiphenomenon is still not completely clear. Although highly conserved within mammals, previous findings showed that all bind rodent MOG. We therefore hypothesized antibody-mediated pathology in...
Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as long (M-1) or short (M-23) isoform. Methodology/Principal Findings The aim of this study was to analyze serum samples from patients controls for presence epitope specificity IgG IgM anti-AQP4...
Background and Purpose: Case series indicating cerebrovascular disorders in coronavirus disease 2019 (COVID-19) have been published. Comprehensive workups, including clinical characteristics, laboratory, electroencephalography, neuroimaging, cerebrospinal fluid findings, are needed to understand the mechanisms. Methods: We evaluated 32 consecutive critically ill patients with COVID-19 treated at a tertiary care center from March 9 April 3, 2020, for concomitant severe central nervous system...
GDP- l -fucose synthase is an autoantigen recognized by cerebrospinal fluid–infiltrating CD4 + T cells from HLA-DRB3* patients with multiple sclerosis.
To expand the spectrum of anti-IgLON5 disease by adding 5 novel anti-IgLON5-seropositive cases with bulbar motor neuron disease-like phenotype.We characterized clinical course, brain MRI and laboratory findings, therapy response in these patients.Patients were severely affected impairment its respiratory consequences. Sleep-related breathing disorders parasomnias common. All patients showed or electrophysiologic signs without fulfilling diagnostic criteria for amyotrophic lateral sclerosis....
Abstract Multiple sclerosis (MS) is a neurological disease of the central nervous system that leading cause non-traumatic disability in young adults. Clinical laboratory tests and neuroimaging studies are standard methods to diagnose monitor MS. However, due infrequent clinic visits, it fundamental identify remote frequent approaches for monitoring MS, which enable timely diagnosis, early access treatment, slowing down progression. In this work, we investigate most reliable , clinically...
Cigarette smoking increases the risk for development of multiple sclerosis and modifies clinical course disease. In this study, we determined whether is a factor early conversion to clinically definite after isolated syndrome.We included 129 patients with syndrome, disseminated white-matter lesions on brain magnetic resonance imaging, positive oligoclonal bands in cerebrospinal fluid. The patients' status was obtained at time syndrome.During follow-up 36 months, 75% smokers but only 51%...
There is accumulating evidence from immunological, pathological and therapeutic studies that B cells are key components in the pathophysiology of multiple sclerosis (MS).In this prospective study we have for first time investigated differences inflammatory response between relapsing progressive MS by comparing cerebrospinal fluid (CSF) cell profiles patients at onset disease (clinically isolated syndrome, CIS), relapsing-remitting (RR) chronic (CP) flow cytometry. As controls used with other...
Background: Olfactory dysfunction has been reported in multiple sclerosis (MS). However, to date no data are available on different qualities of olfactory function, namely odour identification, discrimination and perception threshold. Objective: To assess function patients with MS correlate these demographic data, clinical depression, quality life cognitive functions. Methods: In this cross-sectional study, 50 or clinically isolated syndrome 30 healthy controls were included. was measured...
Multiple sclerosis (MS) has a highly heterogenic course making prediction of long term outcome very difficult.The objective was to evaluate current and identify additional clinical factors that are linked relapsing-remitting MS assessed by disability status 10 years after disease onset.This observational study included 793 patients with MS. Clinical hypothesized influence measured EDSS scores onset were analysed Kaplan-Meier-estimates. Multinomial logistic regression models regarding mild...
BackgroundIn 2008 the Austrian Task Force for Neuromyelitis Optica (NMO) started a nation-wide network information exchange and multi-centre collaboration. Their aim was to detect all patients with NMO or spectrum disorders (NMO-SD) in Austria analyse their disease courses response treatment. Methods(1) As of March 2008, 1957 serum samples (of 1557 patients) have been tested an established cell based immunofluorescence aquaporin-4 antibody (AQP4-ab) assay high sensitivity specificity (both...
To analyze the frequency of NMDA receptor (NMDAR) antibodies in patients with various inflammatory demyelinating diseases CNS and to determine their clinical correlates.Retrospective case-control study from 2005 2014 detection serum IgG NMDAR, aquaporin-4, myelin oligodendrocyte glycoprotein by recombinant live cell-based immunofluorescence assays. Fifty-one acute disseminated encephalomyelitis, 41 neuromyelitis optica spectrum disorders, 34 clinically isolated syndrome, 89 multiple...
Continuous measurement of physiological functions, like heart rate (HR) and variability (HRV), using commercially available wearable sensors provides the prospects improving healthcare individuals with a positive impact on society, bringing pervasiveness, lower cost, broader access. However, common devices use photoplethysmography (PPG) to derive data HR HRV, it is yet unclear which extent PPG signals can be used as proxy for collected medical-grade devices. To address this challenge, we...