A5067314383- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- CNS Lymphoma Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Retinal and Optic Conditions
- Hereditary Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Cerebral Venous Sinus Thrombosis
- Viral-associated cancers and disorders
- interferon and immune responses
- Otitis Media and Relapsing Polychondritis
- Cerebrospinal fluid and hydrocephalus
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Epilepsy research and treatment
- Vasculitis and related conditions
Tohoku University
2016-2025
National Hospital Organization
2018-2024
Fukushima Medical University
2017-2024
Tohoku University Hospital
2017-2023
Tohoku Medical and Pharmaceutical University Hospital
2014-2023
Aomori Prefectural Central Hospital
2019
Miyagi Prefectural Hospital Organization
2019
Miyagi Children's Hospital
2018
Pontifícia Universidade Católica do Rio Grande do Sul
2017
Southern Tohoku General Hospital
2017
To describe the features of adult patients with benign, unilateral cerebral cortical encephalitis positive for myelin oligodendrocyte glycoprotein (MOG) antibody.In this retrospective, cross-sectional study, after we encountered an index case MOG antibody-positive epileptic seizure, tested antibody using our in-house, cell-based assay in a cohort 24 consecutive steroid-responsive unknown etiology seen at Tohoku University Hospital (2008-2014). We then analyzed findings cases.Three more...
Abstract Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM) and brainstem/cerebral cortical encephalitis, but rarely detected prototypic multiple sclerosis. So far, there has been no systematic study on the pathological relationship between demyelinating lesions cellular/humoral immunity MOG antibody-associated disease....
To evaluate cerebrospinal fluid (CSF) cytokine profiles in myelin oligodendrocyte glycoprotein IgG-positive (MOG-IgG+) disease adult and paediatric patients.In this cross-sectional study, we measured 27 cytokines the CSF of MOG-IgG+ acute phase before treatment (n=29). The data were directly compared with those aquaporin-4 antibody-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) (n=20), multiple sclerosis (MS) (n=20) non-inflammatory controls (n=14).In disease, there was...
<h3>Objective</h3> To elucidate the differences in source and level of intrathecal synthesis between anti–aquaporin-4 antibodies (AQP4-IgG) anti-myelin oligodendrocyte glycoprotein (MOG-IgG). <h3>Methods</h3> Thirty-eight patients with MOG-IgG–associated disease 36 AQP4-IgG–positive neuromyelitis optica spectrum disorders (NMOSD) were studied for antibody titers sera CSF simultaneously collected acute attacks. The quotients serum levels albumin, total immunoglobulin G, each disease-specific...
Abstract Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types tissue injury or without complement deposition. However, it unknown whether this diversity derived from differences in pathological processes temporal changes. Furthermore, unlike for demyelinating lesions multiple sclerosis, there has been no staging...
The spectrum of MOG-IgG-associated disease (MOGAD) includes optic neuritis (ON), myelitis (MY), acute disseminated encephalomyelitis (ADEM), brainstem encephalitis, cerebral cortical encephalitis (CE) and AQP4-IgG-negative neuromyelitis optica disorder (NMOSD). In MOGAD, MOG-IgG are usually detected in sera (MOG-IgGSERUM), but there have been some seronegative MOGAD cases with CSF (MOG-IgGCSF), its diagnostic implications remains unclear. this cross-sectional study, we identified patients...
Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein–Barr virus (EBV) infection. A 36-year-old healthy man paresthesia of bilateral lower extremities...
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a newly identified autoimmune demyelinating that often associated with acute disseminated encephalomyelitis and usually occurs postinfection or postvaccination. Here we report case of MOGAD after mRNA severe respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A previously healthy 68-year-old woman presented to our department gradually worsening numbness on the right side her face, which began 14 days...
Objective: The purpose of this study was to elucidate the rapid impact high-dose intravenous methylprednisolone pulse therapy (1,000 mg/day for 3 days) on eventual visual prognosis in patients with serum anti-aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) who had an attack optic neuritis (ON). Methods: Data from 32 consecutive NMOSD (1 male and 31 female) at least one ON attack, involving a total 36 ON-involved eyes, were evaluated. following...
In myelin oligodendrocyte glycoprotein IgG-associated disease (MOGAD) and aquaporin-4 IgG+ neuromyelitis optica spectrum disorder (AQP4+NMOSD), the autoantibodies are mainly composed of IgG1, complement-dependent cytotoxicity is a primary pathomechanism in AQP4+NMOSD. We aimed to evaluate CSF complement activation MOGAD.
Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients.To describe clinical phenotypes associated with anti-MOG.Seventy consecutive Thai patients inflammatory idiopathic demyelinating central nervous system (IIDCD) who were previously anti-AQP4 tested for anti-MOG.Anti-MOG positive six patients, representing 20.7% of the IIDCD a non-multiple sclerosis phenotype, and most had...
Abstract Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system; however, its exact mechanism unknown. This study aimed to elucidate profile white blood cells (WBCs) in acute phase an MS attack. Sixty-four patients with at time diagnosis and 2492 age- sex-adjusted healthy controls (HCs) were enrolled. Data regarding cell counts compared between groups. The total WBC ( p < 0.0001), monocyte basophil = 0.0027), neutrophil 0.0001) higher group than HC group,...
Abstract Startle‐induced seizure is a rare type of reflex triggered by unexpected sensory stimuli that often occurs in children with early acquired cerebral lesions or brain malformations. We report unique case adult‐onset epilepsy startle‐induced seizures. A 24‐year‐old woman had suffered high fever and focal to bilateral tonic–clonic diagnosis febrile infection‐related syndrome (FIRES) was made based on the infection occurring 7 days 24 h before onset status epilepticus, which met all...
ABSTRACT Background Anti‐aquaporin 4 (AQP4) antibody‐positive neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory autoimmune astrocytopathy. While the precise mechanism of autoantibody production has not been completely elucidated, most AQP4‐IgG believed to originate in peripheral lymphoid tissue. Case Presentation Herein, we present rare case overlapping anti‐AQP4 NMOSD and anti‐acetylcholine receptor (anti‐AChR) myasthenia gravis (MG), incidentally accompanied by...