A5043062728- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Sclerosis and Related Diseases
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Hereditary Neurological Disorders
- Rheumatoid Arthritis Research and Therapies
- Sphingolipid Metabolism and Signaling
- Complement system in diseases
- Dementia and Cognitive Impairment Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neurological Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Trigeminal Neuralgia and Treatments
- Bacterial Infections and Vaccines
Siriraj Hospital
2015-2025
Mahidol University
2016-2025
Bumrungrad International Hospital
2015-2025
Charité - Universitätsmedizin Berlin
2021-2024
Humboldt-Universität zu Berlin
2021-2024
Freie Universität Berlin
2021-2024
Max Delbrück Center
2021-2024
Johns Hopkins University
2018
National Cancer Center
2018
Queen Elizabeth Hospital
2018
We aimed to evaluate racial differences in the clinical features of neuromyelitis optica spectrum disorder.This retrospective review included 603 patients (304 Asian, 207 Caucasian, and 92 Afro-American/Afro-European), who were seropositive for anti-aquaporin-4 antibody, from 6 centers Denmark, Germany, South Korea, United Kingdom, States, Thailand.Median disease duration at last follow-up was 8 years (range 0.3-38.4 years). Asian Afro-American/Afro-European had a younger onset age than...
To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) a large international cohort after previous studies have been limited by small heterogeneous cohorts.The cross-sectional Collaborative Retrospective Study on optical coherence tomography (OCT) collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD 72 healthy controls (HCs)....
Our study focused on assessing disease and pregnancy outcomes in Thai patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), a condition that disproportionately affects women of childbearing age poses risks to both mother fetus. We retrospectively analyzed eight NMOSD total 10 pregnancies from our central nervous system inflammatory demyelinating diseases (CNS-IDDs) registry. Over 12-months spanning before 12 months postpartum, we observed 13 relapses, notable 76.92% occurring...
<h3>Objective:</h3> To evaluate the prevalence of aquaporin-4 (AQP4) antibody in Thai patients with idiopathic inflammatory demyelinating CNS diseases (IIDCDs) and to analyze significance autoantibody distinguish neuromyelitis optica (NMO) other NMO spectrum disorders (ONMOSDs) from IIDCDs, especially multiple sclerosis (MS). <h3>Methods:</h3> We retrospectively evaluated 135 consecutive IIDCDs seen at MS clinic Siriraj Hospital, Bangkok, Thailand, classified them into NMO, ONMOSDs,...
Optic neuritis (ON) is one of the common manifestations both in neuromyelitis-optica spectrum disorders (NMOSD) and multiple sclerosis (MS).The objective this paper to compare clinical presentations, laboratories imaging findings ON associated with MS NMOSD.A retrospective chart review was performed patients presenting 59 NMOSD 72 eyes' involvement 163 attacks, 20 23 36 attacks.ON-NMOSD had recurrent more often tended have simultaneous bilateral at their first attack. Individuals ON-NMOSD...
Optic neuritis (ON) often occurs at the presentation of multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). The recommended treatment high-dose corticosteroids for ON is based on a North American study population, which did not address timing or antibody serostatus. Acute Neuritis Network (ACON) presents global, prospective, observational protocol primarily designed to investigate effect...
Abstract Tumefactive demyelinating lesions (TDL), characterized by large (≥ 2 cm) mimicking tumors, are a rare manifestation of the central nervous system inflammatory diseases (CNS-IDD). Distinguishing TDL from other brain can be challenging, often necessitating biopsy or advanced diagnostics. The natural history varies among races. This study aimed to assess demographics, clinical and radiological features, laboratory findings, management, outcomes Thai patients with TDL. We...
Despite rigorous confirmation with reliable assays, some individuals showing the neuromyelitis optica spectrum disorder (NMOSD) phenotype remain negative for both aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies.We aimed to investigate whether double seronegative NMOSD (DN-NMOSD) AQP4 antibody (AQP4-NMOSD) share same pathophysiological basis, astrocytopathy, by measurement of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) levels as a marker...
Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients.To describe clinical phenotypes associated with anti-MOG.Seventy consecutive Thai patients inflammatory idiopathic demyelinating central nervous system (IIDCD) who were previously anti-AQP4 tested for anti-MOG.Anti-MOG positive six patients, representing 20.7% of the IIDCD a non-multiple sclerosis phenotype, and most had...
Abstract Serum neurofilament light chain is a notable biomarker for detecting axonal injury and has shown significant potential clinical applications. Establishing reference interval cut-off level critical step towards implementing serum in routine practice. In this study, we aimed to establish range of chains the Thai population. Blood samples were collected from healthy adults without history neurological diseases screened at Siriraj Hospital. The relationship between age, sex...