A5026098936- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- AI in cancer detection
- Mitochondrial Function and Pathology
Charité - Universitätsmedizin Berlin
2019-2025
Humboldt-Universität zu Berlin
2019-2025
Freie Universität Berlin
2019-2025
Max Delbrück Center
2020-2025
University College London
2023-2024
Einstein Center Digital Future
2024
Moorfields Eye Hospital NHS Foundation Trust
2024
National Hospital for Neurology and Neurosurgery
2023-2024
Ente Ospedaliero Cantonale
2024
University of California, San Francisco
2023
To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) a large international cohort after previous studies have been limited by small heterogeneous cohorts.The cross-sectional Collaborative Retrospective Study on optical coherence tomography (OCT) collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD 72 healthy controls (HCs)....
Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve retinal damage. Evaluating changes using optical coherence tomography (OCT) in like multiple sclerosis has thus become increasingly relevant. However, intraretinal segmentation, a necessary step for interpreting the context of these diseases, is not standardized often requires manual correction. Here we present semi-automatic layer segmentation pipeline establish normative values thicknesses at macula, including...
With the increasing use of visually evoked potentials (VEPs) as quantitative outcome parameters for myelin in clinical trials, an in-depth understanding longitudinal VEP latency changes and their prognostic potential subsequent neuronal loss will be required. In this multicenter study, we evaluated association retinal neurodegeneration, measured by optical coherence tomography (OCT), relapsing-remitting MS (RRMS).We included 293 eyes 147 patients with RRMS (age [years, median ± SD] 36 10,...
Purpose A relative afferent pupillary defect (RAPD) is a characteristic clinical sign of optic neuritis (ON). Here, we systematically evaluated ultrasound pupillometry (UP) for the detection an RAPD in patients with ON, including comparison infrared video (IVP), gold standard objective pupillometry. Materials and methods We enrolled 40 acute (n = 9) or past 31) ON (ON+), 31 multiple sclerosis (MS) without prior 50 healthy controls (HC) cross-sectional observational study. Examinations...
Abstract Background The Uhthoff phenomenon (UP) is a temporary worsening of neurological symptoms due to an increase in body temperature, commonly observed demyelinating diseases, especially multiple sclerosis (MS). Case presentation A 37-year-old female presented with four-year history transient vision impairment the right eye, particularly during dancing. Visual evoked potentials (VEP) revealed prolonged P100 latency and reduced amplitude eye. Optical coherence tomography (OCT) confirmed...
Abstract Optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) regularly leads to more profound vision loss compared multiple sclerosis (MS) and myelin-oligodendrocyte-glycoprotein-antibody associated disease (MOGAD). Here we investigate ON-related NMOSD MS MOGAD order identify neuroaxonal retinal contributors visual dysfunction. In this retrospective study included patients with aquaporin-4-antibody seropositive (n = 28), 14), 29) controls 14). We assessed optic nerve...
Background Patients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this damage a primary astrocytopathy in NMOSD is uncertain. Primary has been suggested cause ON-independent and contribute changes particularly outer plexiform layer (OPL) nuclear (ONL), as reported some earlier studies. However, these were limited...
Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT NMOSD have been limited by the rareness and heterogeneity of disease. The goal this study was to establish an image repository platform, which will facilitate neuroimaging NMOSD. Here we summarise profile Collaborative as initial effort establishing platform. This should prove invaluable for using investigate Participants current cohort...
Abstract Background Spinocerebellar ataxia type 1 (SCA‐ATXN1) is an inherited progressive disorder characterized by adult‐onset cerebellar syndrome combined with nonataxia signs. Retinal or optic nerve affection are not systematically described. Objectives To describe a retinal phenotype and its functional relevance in SCA‐ATXN1. Methods We applied optical coherence tomography (OCT) 20 index cases SCA‐ATXN1 22 healthy controls (HCs), investigating qualitative changes quantifying the...
Abstract Objective The first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these to a prospective, global observational study of acute (ON). Methods included 160 patients with first‐ever ON suggestive demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). 2022 ICON all participants and subsequently adjusted by replacing missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology...
The 2022 International Consortium for Optic Neuritis diagnostic criteria optic neuritis (ON) include optical coherence tomography (OCT). value of intereye difference (IED) metrics is high ON in patients with multiple sclerosis and aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders, but unknown myelin oligodendrocyte glycoprotein antibody-associated (MOG-ON).
Retinal optical coherence tomography (OCT) is increasingly used for quantifying neuroaxonal damage in diseases of the central nervous system such as multiple sclerosis. High-quality OCT images are essential accurate intraretinal segmentation and correct quantification retinal thickness changes. The quality depends largely on operator patient compliance. Quality evaluation time-consuming, current image criteria depend experience grader therefore subjective. automatic graderindependent...
Oertel, Frederike C. MD, PhD; Zimmermann, Hanna G. Motamedi, Seyedamirhosein Bereuter, Charlotte BSc; Asseyer, Eva Susanna MD; Chien, Claudia Marignier, Romain Cobo-Calvo, Alvaro Leocani, Letizia Pisa, Marco Radaelli, Marta Villoslada, Pablo Sanchez-Dalmau, Bernardo Martinez-Lapiscina, Elena H. Lana-Peixoto, Aurélio Fontenelle, Mariana Andrade Aktas, Orhan Ringelstein, Marius Albrecht, Philipp Green, Ari J. Yeaman, Michael R. Smith, Terry Cook, Lawrence Paul, Friedemann Brandt, Alexander U....
To systematically describe the clinical picture of double-antibody seronegative neuromyelitis optica spectrum disorders (DN-NMOSD) with specific emphasis on retinal involvement.