A5101669479- Digital Radiography and Breast Imaging
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- AI in cancer detection
- Radiation Dose and Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Infectious Diseases and Mycology
- Surface Roughness and Optical Measurements
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Infrared Target Detection Methodologies
- Neurogenesis and neuroplasticity mechanisms
- Tuberculosis Research and Epidemiology
- Mesenchymal stem cell research
- Machine Learning in Materials Science
- Long-Term Effects of COVID-19
- Dental Radiography and Imaging
- Radiation Detection and Scintillator Technologies
University of Pennsylvania
2025
Korea University
2024
National Cancer Center
2016-2023
NTL Institute for Applied Behavioral Science
2023
Yonsei University
2012-2021
Institute of Clinical Research
2021
Northwestern University
2021
Merck Serono (Switzerland)
2016
Novartis (Switzerland)
2016
Bayer (Germany)
2016
<h3>Background</h3> We evaluated the seroprevalence of myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG) and associated clinical features patients from a large adult-dominant unselected cohort with mainly relapsing central nervous system (CNS) inflammatory diseases. also investigate relevance MOG-IgG through longitudinal analysis serological status over 2-year follow-up period. <h3>Methods</h3> Serum samples 505 CNS diseases at National Cancer Center were analysed using...
To evaluate the outcomes of immunosuppressive therapy (IST) discontinuation in patients with neuromyelitis optica spectrum disorder (NMOSD) after a sustained remission period.We retrospectively reviewed medical records 17 antiaquaporin-4 antibody-positive NMOSD who discontinued IST relapse-free period ≥3 years.IST was at median age 40 years (interquartile range [IQR], 32-51) 62 months (IQR, 52-73). Among enrolled patients, 14 (82%) relapsed interval 6 4-34) discontinuation, 3 (18%) whom...
Regulatory B cells (Bregs), which protect from autoimmunity, are deficient in multiple sclerosis (MS). Novel regulatory cell subsets CD19+CD24hiCD38hi and CD19+PD-L1hi cells, with disparate mechanisms have been defined. Alemtuzumab provides a long-lasting suppression of disease activity MS. In contrast to its documented efficacy, alemtuzumab's mechanism action is not fully understood information about the composition repopulating pool scarce. To characterize repopulated elucidate...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects optic nerves, spinal cord, and area postrema. A series evidence suggested B cells play a fundamental role in pathogenesis NMOSD. However, there are still gaps left to be answered NMOSD suggesting roles other immune cells. This study aimed investigate monocyte characteristics, subset frequency cytokine production, cell-surface molecule expression...
Serum neurofilament light chain (sNfL) has been proposed a potential biomarker in multiple sclerosis (MS) based on mainly cross-sectional observations Western population. To clarify clinical implication of sNfL, we longitudinally analysed sNfL levels at time points Korean MS patients undergoing alemtuzumab therapy.Between 2016 and 2018, 144 sera from 17 treated with National Cancer Centre 35 age- gender-matched healthy controls (HCs) were collected for longitudinal study mean 21-month...
Despite rigorous confirmation with reliable assays, some individuals showing the neuromyelitis optica spectrum disorder (NMOSD) phenotype remain negative for both aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies.We aimed to investigate whether double seronegative NMOSD (DN-NMOSD) AQP4 antibody (AQP4-NMOSD) share same pathophysiological basis, astrocytopathy, by measurement of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) levels as a marker...
Background and PurposeThe detection of aquaporin 4-IgG (AQP4-IgG) is now a critical diagnostic criterion for neuromyelitis optica spectrum disorder (NMOSD).To evaluate the serostatus NMOSD patients based on 2015 new criteria using in-house cell-based assay (CBA). MethodsWe generated stable cell line internal ribosome entry site-containing bicistronic vectors, which allow simultaneous expression two proteins (AQP4 green fluorescent protein) separately from same RNA transcript.We performed CBA...
Information on subclinical astrocyte damage can provide further insight into neuromyelitis optica spectrum disorder (NMOSD) pathophysiology and disease-monitoring strategies. To investigate whether neuroaxonal occurs during interattack periods in individuals with NMOSD through longitudinal measurement of serum glial fibrillary acidic protein (sGFAP) neurofilament light chain (sNfL) at multiple time points.
The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights immune processes associated with both healthy surveillance as well inflammatory disorders of CNS. latter include demyelinating disorders, such multiple sclerosis (MS) myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), that warrant different therapeutic approaches yet are not always straightforward to distinguish on clinical imaging grounds alone....
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using live cell–based assay for MOG AQP4 antibodies. Of 586 IDDs CNS, 36 (6.1%) 185 (31.6%) tested positive antibodies, respectively. No participant showed double positivity. Seroprevalence was about five times...
Defective regulatory B cells that contribute to autoimmunity are recovered by cell depletion therapy in patients with NMOSD.
The anti-John-Cunningham virus (JCV)-antibody serostatus and index are used in the risk stratification of progressive multifocal leukoencephalopathy (PML) multiple sclerosis (MS) patients treated with natalizumab. However, little information on these parameters is available for Asian countries. purpose this study was to determine rate seropositivity, index, longitudinal evolution Korean MS.The antibody seroprevalence analyzed 355 samples from 187 clinically isolated syndrome or MS using a...
Alemtuzumab is a potent monoclonal CD52 antibody used to treat patients with multiple sclerosis (MS). However, recent literature reports have described paradoxical activation of B cell–mediated disease within 1 year the first cycle alemtuzumab. We raise awareness that severe could develop, even after two cycles alemtuzumab, in some vulnerable MS patients; therefore, individualized therapeutic strategies should be considered clinical practice. also propose novel regulatory B-cell subset may...
Introduction: The optimal duration of immunosuppressive therapy (IT) for neuromyelitis optica spectrum disorder (NMOSD) has not been established. Here, we report a case severe relapse after early cessation IT. Case Report: A 32-year-old woman presented with 2-week history intractable vomiting and hiccups followed by quadriplegia respiratory insufficiency. Spinal cord MRI showed longitudinally extensive transverse myelitis (LETM) aquaporin-4-immunoglobulin-G (AQP4-IgG) was positive. She...