A5100359564- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- Systemic Lupus Erythematosus Research
- Cerebrovascular and genetic disorders
- Nuclear Receptors and Signaling
- Antifungal resistance and susceptibility
- Neural dynamics and brain function
- Shoulder Injury and Treatment
- Food Quality and Safety Studies
- Myasthenia Gravis and Thymoma
- Herpesvirus Infections and Treatments
- Musculoskeletal pain and rehabilitation
- Autophagy in Disease and Therapy
- Genetic Neurodegenerative Diseases
- Rheumatoid Arthritis Research and Therapies
- Neurological diseases and metabolism
- Orthopedic Surgery and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Medical Research and Treatments
- Orthopaedic implants and arthroplasty
- Retinal Development and Disorders
- melanin and skin pigmentation
Asan Medical Center
2016-2025
Ulsan College
2016-2025
University of Ulsan
2016-2025
Korea Institute of Brain Science
2024-2025
Korea Institute of Science and Technology
2024-2025
Korean Association Of Science and Technology Studies
2024-2025
Korea Advanced Institute of Science and Technology
1995-2025
Neurology, Inc
2025
John Wiley & Sons (United States)
2024
Hudson Institute
2024
<h3>Objective</h3> To test the hypothesis that pattern of serum biomarkers disease activity and disability in myelin oligodendrocyte glycoprotein antibody–associated (MOGAD) will be different from those neuromyelitis optica spectrum disorder (NMOSD) with anti–aquaporin-4 antibodies (AQP4-Abs). <h3>Methods</h3> Using ultrasensitive single-molecule array assays, we measured neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau sera consecutive patients MOGAD (n = 16)...
This study evaluated the diagnostic utility of an anti-signal-recognition particle 54 (anti-SRP54) antibody-based enzyme-linked immunosorbent assay (ELISA) as well clinical, serological, and pathological characteristics patients with SRP immune-mediated necrotizing myopathy (IMNM). We 87 idiopathic inflammatory 107 healthy participants between January 2002 December 2023. The sensitivity specificity ELISA for anti-SRP54 antibodies were assessed, clinical profiles determined. had a 88% 99%,...
Background: Research on the optimal duration of immunosuppressive therapy (IST) and outcome upon its discontinuation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains limited. Objective: To evaluate outcomes following IST MOGAD. Methods: This multicenter retrospective study collected data from 333 MOGAD patients Korea. Among 273 who received IST, 41 discontinued were analyzed. Results: The median age at onset was 38.3 years (interquartile range (IQR),...
Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) new-onset seizure. Methods Adult (age ≥18 years) AE who underwent were followed-up for at least 6 months included. Seizure frequency was evaluated 2–4 weeks onset of initial categorized as “seizure remission”, “> 50% reduction”, or “no change” based on degree its decrease. Results Forty-one presented analysed. At immunotherapy, 51.2% free, 24.4% had...
Intracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy are more common East Asian populations than people of white European ancestry. We hypothesized that the ethnic difference is explained by Asian-specific NOTCH3 p.R75P mutation.
Background: Differentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is crucial in the field of diagnostics because, despite their similarities, treatments for these two diseases are substantially different, and disease-modifying MS can worsen NMOSD. As brain magnetic resonance imaging (MRI) an important tool to distinguish diseases, extensive research has been conducted identify defining characteristics MRI images corresponding diseases. However,...
Abstract Neuropathic pain is a debilitating condition caused by the hyperexcitability of spinal dorsal horn neurons and often characterized allodynia. Although neuron-independent mechanisms have been investigated, contribution astrocyte-neuron interactions remains unclear. Here, we show evidence reactive astrocytes their excessive GABA release in horn, which paradoxically leads to tonic excitation neighboring neuropathic model. Using multiple electrophysiological methods, demonstrated that...
Importance A proportion of people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) have a relapsing course and persistent anti–myelin immunoglobulin G (MOG-IgG) seropositivity. Few studies investigated whether treatment the first MOGAD attack is associated long-term and/or MOG-IgG seronegative conversion. Objective To investigate association time to treat acute relapse risk serostatus. Design, Setting, Participants This was retrospective, nationwide, multicenter...
DJ-1 is one of the causative genes for early onset familiar Parkinson's disease (PD) and also considered to influence pathogenesis sporadic PD. has various physiological functions which converge on controlling intracellular reactive oxygen species (ROS) levels. In RNA-sequencing analyses searching novel anti-oxidant downstream DJ-1, a gene encoding NADP+-dependent isocitrate dehydrogenase (IDH), converts into α-ketoglutarate, was detected. Loss IDH induced hyper-sensitivity oxidative stress...
Abstract Objectives Serum synaptic proteins levels may change with age‐related neurodegeneration, affecting their clinical implications as a disease biomarker. We aimed to investigate neuronal and astroglial markers in patients multiple sclerosis (MS) aquaporin‐4 antibody‐seropositive neuromyelitis optica spectrum disorders (NMOSD) compare the of these according age. Methods Using single‐molecule array assays, we measured neurofilament light (NfL) glial fibrillary acidic protein (GFAP) sera...
Background: Recently, several serum biomarkers have been proposed in Neuromyelitis Optica Spectrum Disorders (NMOSD) to monitor disease activity. Objective: The objective of the study is evaluate longitudinal clinical value patients with NMOSD. Methods: We prospectively recruited consecutive NMOSD anti-aquaporin-4 antibody and obtained samples at enrollment, after 6–12 months follow-up (main period), attacks. Using single-molecule array assays, we evaluated changes neurofilament light chain...
Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine causes various psychiatric neurological disorders. Despite this significance, the true biological nature remains poorly understood. Here, we show that transmission is strongly correlated with GABA co-transmission across brain are structured function like GABAergic marked regional heterogeneity. In addition, GABAergic-like clustered on dendrites, at has distinct...
The purpose of study was to determine the nature, outcomes and associated risk factors invasive fungal infection (IFI) in patients with systemic lupus erythematosus (SLE), compare incidence IFI rheumatoid arthritis (RA). A total 1155 SLE 2004 RA were retrospectively reviewed between 1992 2007. Twelve cases identified (6 Aspergillus spp.; 5 Cryptococcus 1 Candida spp.). significantly higher than (1.04 vs. 0.15%). Among 12 SLE, 10 had high Systemic Lupus Erythematosus Disease Activity Index...
Abstract Immersive technologies like virtual reality (VR) and augmented (AR) are rapidly advancing, but current motion tracking systems face significant limitations. Camera‐based methods struggle with occlusion environmental sensitivity, while existing skin‐applied sensors suffer from poor adhesion or lack of reusability. This research introduces a deep‐learning‐based monitoring system utilizing skin‐conformal stretchable film for reliable immersive in VR AR applications. The approach...