A5100619125- Sleep and related disorders
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Hereditary Neurological Disorders
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Obstructive Sleep Apnea Research
- Neurological Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Neurological disorders and treatments
- Sleep and Work-Related Fatigue
- Blind Source Separation Techniques
- Transcranial Magnetic Stimulation Studies
- Cognitive Abilities and Testing
- Health and Wellbeing Research
- Laser Applications in Dentistry and Medicine
- Peroxisome Proliferator-Activated Receptors
Korea University
2021-2025
Asan Medical Center
2025
Ansan University
2021-2024
Ewha Womans University Medical Center
2016-2023
Ewha Womans University
2013-2023
Seoul National University
2020
Seoul National University Hospital
2012-2020
Baewha Women's University
2019
Jeju National University Hospital
2018
Jeju National University
2018
Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) new-onset seizure. Methods Adult (age ≥18 years) AE who underwent were followed-up for at least 6 months included. Seizure frequency was evaluated 2–4 weeks onset of initial categorized as “seizure remission”, “> 50% reduction”, or “no change” based on degree its decrease. Results Forty-one presented analysed. At immunotherapy, 51.2% free, 24.4% had...
The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because more prevalent than hemorrhage in the general population. This study aimed to determine predicting factors for recurrence survivors and develop a clinical scoring system prediction risks first PSSi.We reviewed 3792 who had admitted Ewha Womans University hospital between 2001 2012. A total 124 (3.3 %) experienced PSSi were recruited (mean follow-up 44.4 months). Medical...
Abstract Background Mutations in the Pleckstrin homology domain-containing, family G member 5 ( PLEKHG5 ) gene has been reported a harboring an autosomal recessive lower motor neuron disease (LMND). However, mutation not described to cause Charcot-Marie-Tooth (CMT). Methods To identify causative intermediate CMT (RI-CMT) with childhood onset, whole exome sequencing (WES), histopathology, and leg MRIs were performed. Expression activity of each mutant protein analyzed. Results We identified...
To investigative whether radiomics features in bilateral hippocampi from MRI can identify temporal lobe epilepsy (TLE). A total of 131 subjects with (66 TLE patients [35 right and 31 left TLE] 65 healthy controls [HC]) were allocated to training (n = 90) test 41) sets. Radiomics 186) the extracted T1-weighted images. After feature selection, machine learning models trained. The performance classifier was validated set differentiate HC ipsilateral HC. Identical processes performed (training...
Study Objectives: The sleep patterns of humans are greatly influenced by age and sex have various effects on overall health as they change continuously during the lifespan.We investigated age-dependent changes in properties their relation to middle-aged individuals.Methods: We analyzed data from 2,640 participants (mean 49.8 ± 6.8 years at baseline, 50.6% women) Korean Genome Epidemiology Study, which assessed habits using Pittsburgh Sleep Quality Index other clinical characteristics.We...
Here, we report the structural evidence of cerebral white matter abnormalities in Charcot‐Marie‐Tooth (CMT) patients and relationship between these clinical disability. Brain diffusion tensor imaging (DTI) was performed CMT with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI‐CMT) peripheral neuropathy. Although all had normal brain magnetic resonance imaging, genetic subgroups except CMT1A abnormal DTI findings indicative significant abnormalities: decreased...
BackgroundThe all-cause and cause-specific mortality risk associated with sleep latencies in the general adult population is unknown. We aimed to investigate association of habitual prolonged latency long-term adults.MethodsThe Korean Genome Epidemiology Study (KoGES) a population-based prospective cohort study comprising community-dwelling men women aged 40–69 years from Ansan, South Korea. The was studied bi-annually April 17, 2003, Dec 15, 2020, current analysis included all individuals...
Abstract Study Objectives Evidence suggests that sleep–wake cycle disruption could be an early manifestation of neurodegeneration and might even a risk factor for developing diseases in healthy adults. We investigated the impact circadian phase change on structural functional brain deterioration late-adulthood population. Methods analyzed data 1874 participants (mean age 58.6 ± 6.3 years, 50.3% female) from Korean Genome Epidemiology Study, who were identified as cognitively unimpaired. The...
Summary Objective Patients with temporal lobe epilepsy ( TLE ) show brain connectivity changes in association cognitive impairment. Seizure frequency and lateralization are 2 important clinical factors that characterize epileptic seizures. In this study, we sought to examine an interactive effect of the seizure on intratemporal effective based resting‐state functional magnetic resonance imaging (rsf MRI patients . Methods For rsf data acquired from 48 45 healthy controls, applied stochastic...
Sleep is an essential function to sustain a healthy life, and sleep dysfunction can cause various physical mental issues. In particular, obstructive apnea (OSA) one of the most common disorders and, if not treated in timely manner, OSA lead critical problems such as hypertension or heart disease.The first crucial step evaluating individuals' quality diagnosing classify stages using polysomnographic (PSG) data including electroencephalography (EEG). To date, stage scoring has been mainly...
The use of automatic electrical stimulation in response to early seizure detection has been introduced as a new treatment for intractable epilepsy. For the effective application this method successful treatment, improving accuracy is crucial. In paper, we proposed frequency-based algorithm derived from principal component analysis (PCA), and demonstrated improved efficacy pilocarpine-induced epilepsy rat model. A total 100 ictal electroencephalographs (EEG) during spontaneous recurrent...
Benign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between performance and altered functional connectivity (FC) in resting-state brain networks of BECTS patients. studied 42 subjects, comprising 19 patients 23 healthy controls. Cognitive was assessed using Korean version Wechsler Intelligence Scale for Children-III, addition to verbal visuospatial memory tests executive function tests. Resting-state...
Brain functional integration can be disrupted in patients with temporal lobe epilepsy (TLE), but the clinical relevance of this disruption is not completely understood. The authors hypothesized that over brain regions remote from, as well adjacent to, seizure focus could related to severity terms control and memory impairment. Using resting-state MRI data acquired from 48 TLE 45 healthy controls, mapped networks assessed changes a network parameter integration, efficiency, examine...
Obstructive sleep apnea (OSA) is associated with cerebral white-matter changes (WMC), but the underlying mechanisms are not completely understood. Our aim was to identify cardiovascular autonomic characteristics during that WMC in OSA patients. We recruited subjects from our sleep-center database who underwent both polysomnography and brain MRI within a 1-year period. Sixty patients had (OSA+WMC), 44 without (OSA-WMC), 31 control neither nor were analyzed. Linear nonlinear indices of...
Hani Kim, Yunsook Choi, Hye-Young Joung, Yun Seo Hyeon Jin Yohan Joo, Jin-Hwan Oh, Hoo Jae Hann, Zang-Hee Cho and Hyang Woon Lee. Exp Neurobiol 2017;26:287-94. https://doi.org/10.5607/en.2017.26.5.287
This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; Lactium®) on subjective and objective sleep profiles a community-based sample Koreans with poor quality. We performed double-blind, randomized crossover trial 48 participants (49.0 ± 1.7 years old, 65% female) who exhibited mild to moderate degree disturbance. Either ACH or placebo was administered for initial four weeks, counterpart in precisely same manner after four-week washout period. Sleep disturbance scales, daytime...
Background and Objective Firefighters suffer from irregular inadequate sleep, often due to their shift work schedule. The purpose of this study was investigate the schedules effects on quality sleep in Korean firefighters. Methods This included firefighters Seoul Metropolitan area, who participated "Firefighters' Healing Camp" answered questionnaires for sleep-related symptoms. Among 180 participating firefighters, 110 subjects completed detailed questionnaires, which Pittsburgh Sleep...
Background: Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that overexpressed in several types of epithelial cancers, and suggested to be associated with an unfavorable prognosis.BRAF mutations are the most common genetic alteration papillary thyroid carcinoma (PTC).We evaluated correlation between TROP2 expression BRAF mutation PTC.Methods: First, we carried out pyrosequencing for immunohistochemistry tissue microarray consisting 52 PTC cases.Membranous...
Abstract Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl- d -aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to pathophysiology of psychiatric disorders such as schizophrenia. We aimed establish interaction mGluR5 NMDA receptors in brain mice with genetic ablation mGluR5. Methods first measured levels magnetic resonance spectroscopy (MRS) knockout (KO) wild-type (WT) mice. Then, we...
Abstract Study Objectives Sleep behaviors are related to brain structure and function, but the impact of long-term changes in sleep timing on health has not been clearly addressed. The purpose this study was examine association longitudinal from middle late-life with gray matter volume (GMV), an important marker aging. Methods We enrolled 1798 adults (aged 49–82 years, men 54.6%) who underwent magnetic resonance imaging (MRI) between 2011 2014. Midsleep time (MST) free days corrected for...
Electroencephalography (EEG) recording during sleep is a powerful tool for studying neural oscillatory dynamics. Current practice, however, limits our ability to observe the potentially-important features of sleeping brain because it focuses on discrete stage-based averaging manually labeled metrics. This study proposes high-resolution objective framework that can comprehensively represent individualized continuous states sleep. We develop computational around novel visualization called...
Although a connection between sleep disruption and brain aging has been documented, biological mechanisms need to be further clarified. Intriguingly, is associated with circadian rhythm and/or dysfunction in key gene regulating rhythm, Circadian Locomotor Output Cycles Kaput (CLOCK), linked both aging-related disturbances neurodegenerative diseases. This study aims investigate how CLOCK genetic variation associates duration changes volumetric alteration.This population-based cross-sectional...
Background/Aims: Small subepithelial tumors (SETs) are often found incidentally during esophagoduodenoscopy, and EUS is a useful tool for assessing SETs.This study aimed to evaluate the natural history of SETs clarify predictive factors growth using EUS.Materials Methods: We retrospectively investigated less than 30 mm identified features.A significant increase in SET size was defined as lengthening more 25% longest diameter last follow-up features compared with initial study.Results: A...