A5040032962- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Silicon Nanostructures and Photoluminescence
- Sleep and Wakefulness Research
- Semiconductor materials and devices
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Moyamoya disease diagnosis and treatment
- Peripheral Neuropathies and Disorders
- Restless Legs Syndrome Research
- Cardiovascular Health and Disease Prevention
- Silicon and Solar Cell Technologies
- Parkinson's Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Thin-Film Transistor Technologies
Seoul National University Hospital
2016-2025
Seoul National University
2016-2025
New Generation University College
2013-2025
National University College
2013-2025
Asan Medical Center
2011-2023
Seoul National University Bundang Hospital
2010-2023
University of Ulsan
2011-2023
Ulsan College
2011-2023
Korea University Medical Center
2007-2023
University of the East Ramon Magsaysay Memorial Medical Center
2023
Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged brain after stroke. In this study, however, we effect on acute cerebral and peripheral inflammation intracerebral haemorrhage (ICH). NSCs (H1 clone) from fetal human were injected intravenously (NSCs-iv, 5 million cells) or intracerebrally (NSCs-ic, 1 at 2 24 h collagenase-induced ICH in rat model. Only NSCs-iv-2 resulted fewer initial neurologic deteriorations reduced oedema formation,...
Alzheimer disease (AD) brains are deficient in brain-derived neurotrophic factor (BDNF), which regulates synaptic plasticity and memory. MicroRNAs (miRNAs) ∼22-nucleotide small noncoding RNAs that control a variety of physiological processes. Here, we show miR-206 BDNF memory function AD mice.Expression miRNAs was analyzed Tg2576 transgenic mice human brain samples. Regulation by selected miRNA validated silico prediction, target gene luciferase assay, dendritic spine responses neurons....
<h3>Objective:</h3> To determine efficacy and safety of rituximab treatment as a second-line immunotherapy for autoimmune limbic encephalitis (ALE) to factors associated with functional improvement favorable outcome following treatment. <h3>Methods:</h3> We recruited 80 patients ALE who were treated from the Korea Autoimmune Synaptic Paraneoplastic Encephalitis Registry reviewed 81 without control. grouped according detection or type antibodies; in addition, we evaluated clinical,...
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel in patients with diverse AE syndromes and verify reliability validity developed scale.The key items were generated by panel experts selected according content ratios. The was initially applied 50 (development cohort) evaluate its acceptability, reproducibility, internal consistency, construct validity. Then, another independent cohort (validation cohort, n = 38).A new...
To prospectively evaluate the effect of accelerated deep learning-based reconstruction (Accel-DL) on improving brain magnetic resonance imaging (MRI) quality and reducing scan time compared to that in conventional MRI. This study included 150 participants (51 male; mean age 57.3 ± 16.2 years). Each group 50 was scanned using one three 3T scanners from different vendors. Conventional Accel-DL MRI images were obtained each participant 2D T1- T2-weighted 3D gradient-echo sequences. acquisition...
Background and Purpose— Cell transplantation has been used to reduce behavioral deficit in cerebral ischemia. However, there is no report about cell experimental intracerebral hemorrhage (ICH). We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate differentiate into neurons or glial cells, thereby improving functional outcome ICH. Methods— Experimental ICH was induced by intrastriatal administration of bacterial collagenase adult rats. One day after...
Hyperglycemia has a deleterious effect on brain ischemia. However, the of hyperglycemia in intracerebral hemorrhage (ICH) is not well known. We investigated development edema and perihematomal cell death ICH.Hyperglycemia was induced by intraperitoneal injection streptozotocin (60 mg/kg) adult Sprague-Dawley male rats. ICH stereotaxic infusion 0.23 U collagenase into left striatum. Seventy-two hours after ICH, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling...
Background and Purpose— The rate of nitric oxide (NO) generation from nitrite is linearly dependent on reductions in oxygen pH levels. Recently, nitrite-derived NO has been reported to exert a profound protection against liver heart ischemia-reperfusion injury. In this study, we hypothesized that would be reduced the ischemic brain NO-dependent neuroprotective effects. Methods— Cerebral injury was induced by intraluminal thread occlusion middle cerebral artery adult male rats. Solutions...
Background and Purpose— MicroRNAs (miRNA) are single-stranded short RNA molecules that regulate gene expression by either degradation or translational repression of mRNA. Although miRNAs control a number conditions diseases, few neuroprotective have been described. In this study, we investigated induced early in ischemic preconditioning. Methods— Ischemic preconditioning focal cerebral ischemia was mice transient occlusion the middle artery for 15 120 minutes. We prepared samples from cortex...
Statins have neuroprotective effects on ischemic stroke. They modify the endothelial function, increase blood flow, and inhibit thrombus formation, which are independent of lipid-lowering effects. However, whether statins a protective effect toward hemorrhagic stroke is yet unknown. To test this possibility, we attempted to determine atorvastatin experimental intracerebral hemorrhage (ICH).ICH was induced using stereotaxic infusion collagenase into left basal ganglia in adult rats....
<b>Objective: </b> Migraine carries an increased risk for cardiovascular and cerebrovascular diseases that cannot be explained by traditional factors. The circulating endothelial progenitor cell (EPC) number is a surrogate biologic marker of vascular function, diminished EPC counts are associated with higher risk. We investigated whether abnormalities in levels functions present migraine patients. <b>Methods: Consecutive headache patients (n =166) were enrolled, including those tensiontype...
Astrocytic glutamate transporter protein, GLT-1 (EAAT2), recovers extracellular and ensures that neurons are protected from excess stimulation. Recently, beta-lactam antibiotics, like ceftriaxone (CTX), were reported to induce the upregulation of GLT-1. Here, we investigated ischemic tolerance induction by CTX in an experimental model focal cerebral ischemia.CTX (200 mg/kg per day, IP) was administered for 5 consecutive days before transient ischemia, which induced intraluminal thread...
The selective cyclooxygenase-2 (COX-2) inhibitor has been reported to have antiinflammatory, neuroprotective, and antioxidant effects in ischemia models. In this study, the authors examined whether a COX-2 (celecoxib) reduces cerebral inflammation edema after intracerebral hemorrhage (ICH), functional recovery is sustained with longer treatment. ICH was induced using collagenase adult rats. Celecoxib (10 or 20 mg/kg) administered intraperitoneally minutes, 6 hours, 24 hours then daily...
Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal autoantibodies. However, its immunopathogenesis is not fully understood. Here, we investigated whether AE associated with the human leukocyte antigen (HLA) subtypes.We compared HLA genotypes 11 anti-LGI1 17 anti-NMDAR patients to control groups, which...