A5057203654- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Primate Behavior and Ecology
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Military Defense Systems Analysis
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Animal Behavior and Reproduction
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Pluripotent Stem Cells Research
- Tryptophan and brain disorders
- Mobile Agent-Based Network Management
- Photoacoustic and Ultrasonic Imaging
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Insect and Arachnid Ecology and Behavior
- Neurological disorders and treatments
- Advanced Fluorescence Microscopy Techniques
Ulsan National Institute of Science and Technology
2016-2025
Seoul National University
2008-2025
Institute for Basic Science
2025
Dongguk University
2025
University of Ulsan
2024
Seoul National University Hospital
2022
Korea University
2022
Korea University of Science and Technology
2022
Bio-Medical Science (South Korea)
2022
Korea Institute of Science and Technology
2022
Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little known about whether or not degradation involved in the reorganization of retrieved memory. We found postsynaptic proteins were degraded hippocampus by polyubiquitination after contextual fear Moreover, infusion proteasome inhibitor CA1 region immediately prevented anisomycin-induced...
An alternative way of making GABA Midbrain dopaminergic neurons release both the inhibitory neurotransmitter and dopamine. In central nervous system, synthesis is usually mediated by two glutamate decarboxylases (GAD65 GAD67). Kim et al. found that midbrain use a different, evolutionary conserved pathway independent GAD65 GAD67. These cells synthesize from putrescine via enzymes diamine oxidase aldehyde dehydrogenase 1a1. synthesized this accounts for approximately 70% co-released GABA....
Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic expressed these glutamatergic inputs; however, whether eCB-LTD can induced all inputs on striatal neurons still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated distinguished between projections. We found that was...
MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression in many tissues. Although a number of brain-enriched miRNAs have been identified, only few specific revealed as critical regulators synaptic plasticity, learning, and memory. miR-9-5p/3p known to development their changes implicated several neurological disorders, yet role mature neurons mice is largely unknown. Here, we report inhibition miR-9-3p, but not miR-9-5p, impaired hippocampal long-term...
The dopamine system in the midbrain is essential for volitional movement, action selection, and reward-related learning. Despite its versatile roles, it contains only a small set of neurons brainstem. These are especially susceptible to Parkinson's disease prematurely degenerate course progression, while discovery new therapeutic interventions has been disappointingly unsuccessful. Here, we show that O-GlcNAcylation, an post-translational modification various types cells, critical...
Highlights•Loss of TGF-β1 regulates excitatory-inhibitory inputs in DA neurons via autocrine mechanism•TGF-β signaling reduces axonal and dendritic growth neurons•Mice lacking TGF-β are persistently hyperactive•Mice exhibit reversal-learning deficitsSummaryNeural circuits involving midbrain dopaminergic (DA) regulate reward goal-directed behaviors. Although local GABAergic input is known to modulate circuits, the mechanism that controls excitatory/inhibitory synaptic balance remains unclear....
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both which are involved in mobilization Ca(2+) from intracellular stores. Recently, has been shown to regulate oxytocin release hypothalamic neurons. Importantly, mutations associated with autism spectrum disorders (ASD) knockout (CD38(-/-)) mice display ASD-like behavioral phenotypes including deficient parental behavior poor social recognition memory. Although ASD learning...
Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine causes various psychiatric neurological disorders. Despite this significance, the true biological nature remains poorly understood. Here, we show that transmission is strongly correlated with GABA co-transmission across brain are structured function like GABAergic marked regional heterogeneity. In addition, GABAergic-like clustered on dendrites, at has distinct...
Generation of autologous human motor neurons holds great promise for cell replacement therapy to treat spinal cord injury (SCI). Direct conversion allows generation target cells from somatic cells, however, current protocols are not practicable therapeutic purposes since converted post-mitotic that scalable. Therefore, effects directly have been elucidated yet. Here, we show fibroblasts can be into induced (iMNs) by sequentially inducing POU5F1(OCT4) and LHX3. Our strategy enables scalable...
Nonlinear microscopy provides excellent depth penetration and axial sectioning for 3D imaging, yet widespread adoption is limited by reliance on expensive ultrafast pulsed lasers. This work circumvents such limitations employing rare-earth doped upconverting nanoparticles (UCNPs), specifically Yb3+/Tm3+ co-doped NaYF4 nanocrystals, which exhibit strong multimodal nonlinear optical responses under continuous-wave (CW) excitation. These UCNPs emit multiple wavelengths at UV (λ ≈ 450 nm), blue...
Abstract Phospholipase C (PLC) enzymes play crucial roles in intracellular calcium-signaling transduction. Several brain PLC subtypes have been extensively studied, implicating them psychiatric disorders such as depression, epilepsy and schizophrenia. However, the role of recently identified PLCη remains largely unknown. We found that PLCη1 is prominently expressed lateral habenula (LHb) astrocytes. Here, to investigate its physiological role, we generated astrocyte-specific conditional...
We recently reported that the dopamine (DA) analogue CA140 modulates neuroinflammatory responses in lipopolysaccharide-injected wild-type (WT) mice and 3-month-old 5xFAD mice, a model of Alzheimer's disease (AD). However, effects on Aβ/tau pathology synaptic/cognitive function its molecular mechanisms action are unknown. To investigate cognitive synaptic AD pathology, WT or 8-month-old (aged) were injected with vehicle (10% DMSO) (30 mg/kg, i.p.) daily for 10, 14, 17 days. Behavioral tests,...
Abstract Dopamine (DA) affects voluntary movement by modulating basal ganglia function. In the classical model, DA depletion leads to overactivity of indirect pathway and excessively inhibits thalamus, resulting in hypokinesia. The contribution on striatopallidal synapses, an initial hub connecting striatum external globus pallidus (GPe), remains poorly understood because sparse innervation. Here, we combine optogenetic projection targeting, whole cell patch clamp recordings acute brain...
Abstract Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. memory recall reactivates consolidated trace across multiple brain regions, and several studies have suggested that these recall-activated neurons are re-engaged during extinction. However, molecular mechanisms linking this reactivation to remain largely elusive. Here, we investigated role N-Methyl- d -Aspartate receptors (NMDARs) remote...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson9s disease (PD), but pathogenic mechanism underlying LRRK2 mutations remains unresolved. In this study, we investigate consequence inactivation and its functional homolog LRRK1 male female mice up to 25 months age using behavioral, neurochemical, neuropathological, ultrastructural analyses. We report that <i>LRRK1</i> <i>LRRK2</i> double knock-out (<i>LRRK</i> DKO) exhibit impaired motor...