A5100747692- Advanced Breast Cancer Therapies
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- interferon and immune responses
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Cannabis and Cannabinoid Research
- NF-κB Signaling Pathways
- Ion channel regulation and function
- Thyroid Cancer Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Autism Spectrum Disorder Research
- Memory and Neural Mechanisms
- Healthcare and Venom Research
- Cytokine Signaling Pathways and Interactions
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Microtubule and mitosis dynamics
- Neurobiology and Insect Physiology Research
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Estrogen and related hormone effects
Kyungpook National University
2014-2025
Kyung Hee University
2021-2025
Korea Institute of Science and Technology
2021-2025
Materials Research Center
2025
Hanyang University
2023-2024
Korea Institute of Brain Science
2021-2024
Sungkyunkwan University
2023-2024
University of California, Irvine
2018-2024
CJ CheilJedang (South Korea)
2024
Seoul National University
2007-2023
Pain in the Brain One of major challenges pain research is finding ways to reverse chronic pain. Synaptic long-term potentiation (LTP) at spinal or cortical levels a cellular model X.-Y. Li. et al. (p. 1400 ) studied role enzyme protein kinase M zeta (PKMζ) neurons anterior cingulate cortex (ACC) maintenance LTP and for enhanced sensitivity after peripheral nerve injury mice. Nerve appeared lead up-regulation phosphorylation PKMζ. This triggered some synapses ACC by increasing number AMPA...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth differentiation, immune functions cancer. It activated by various cytokines, factors, protein tyrosine kinases (PTKs) regulates the genes. Of four JAK isoforms seven STAT known, JAK2 STAT3 are highly expressed brain where they present postsynaptic density (PSD). Here, we demonstrate a new neuronal function for JAK/STAT pathway. Using variety...
Abstract Cyclooxygenase‐2 (COX‐2) is a major contributor to the elevation of spinal prostaglandin E2 , which augments processing nociceptive stimuli following peripheral inflammation, and dynorphin has been shown have an important role in acute chronic pain states. Moreover, transcription factor, nuclear factor‐kappa B (NF‐kB), regulates expressions both COX‐2 dynorphin. To elucidate NF‐kB induction inflammatory hypersensitivity, we examined whether activated affects behavior mRNAs...
// Hye-Youn Kim 1, * , Kyung-Min Lee So-Hyun 1 Yeo-Jung Kwon Young-Jin Chun Hyung-Kyoon Choi College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic Korea These authors have contributed equally to this work Correspondence to: Chun, email: yjchun@cau.ac.kr Choi, hykychoi@cau.ac.kr Keywords: metastasis, breast cancer cells, metabolomics, lipidomics, PLSR Received: May 04, 2016 Accepted: August 11, Published: 24, ABSTRACT This study conducted comprehensive and comparative metabolic...
The intrathecal administration of p38 MAP kinase (p38) inhibitor has been shown to reduce hyperalgesia. In the present study, we investigated activation in rat dorsal root ganglion (DRG) and spinal cord following peripheral tissue inflammation nerve injury immunohistochemically. Peripheral chronic constriction (CCI) sciatic induced a significant increase percentage phosphorylated (P-) p38-immunoreactive (IR) neurons, primarily small sized ones bilateral DRGs. contrast, axotomy, decrease IR...
To evaluate the alveolar bone loss around lower incisors incurred during surgical orthodontic treatment in individuals with mandibular prognathism.The samples consisted of 25 patients (13 men, 12 women; mean ages: 26.3 ± 2.7 years) treated jaw surgery and treatment. Lateral frontal cephalograms cone-beam computed tomography (CBCT) images were obtained before (T0) after presurgical (T1) debonding (T2). After measurement variables, repeated-measures analysis variance Bonferroni's multiple...
The memory reconsolidation hypothesis suggests that a trace becomes labile after retrieval and needs to be reconsolidated before it can stabilized. However, is unclear from earlier studies whether the same synapses involved in encoding are those destabilized restabilized synaptic reactivation accompanies retrieval, or new different recruited. To address this issue, we studied simple nonassociative form of memory, long-term sensitization gill- siphon-withdrawal reflex Aplysia , its cellular...
Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, the targeted delivery of therapeutic agents. Safety concerns about biomedical clinical applications SiNPs have been raised, necessitating analysis effects their intrinsic properties, such as sizes, shapes, surface physicochemical characteristics, on human health to minimize risk in applications. In particular, SiNP size-associated toxicological effects, underlying molecular mechanisms vascular endothelium remain...
Mesenchymal stem cell (MSC)-mediated therapy has been shown to be clinically effective in regenerating tissue defects. For improved regenerative therapy, it is critical isolate homogenous populations of MSCs with high capacity differentiate into appropriate tissues. The utilization surface antigens provides a means identify from various However, few markers that consistently highly have validated, making challenging for routine clinical applications and all the more imperative reliable...
Abstract The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility. Although recent studies have reported that EGFR signaling is involved osteoclast recruitment formation, the molecular mechanism of for regulation osteoclastogenesis remains unclear. We investigated role differentiation survival show expression was highly up‐regulated by activator nuclear factor‐κB ligand (RANKL) during...
Peripheral nerve injury leading to neuropathic pain induces the upregulation of interleukin (IL)-6 and microglial CX3CR1 expression, activation p38 mitogen-activated protein kinase (MAPK) in spinal cord. Here, we investigated whether IL-6 regulates expression through MAPK cord rats with chronic constriction (CCI) sciatic nerve. Similar temporal changes IL-6, phosphorylated were observed following CCI. The increases behavior after CCI suppressed by blocking action a neutralizing antibody,...
Long-term depression (LTD) is a key form of synaptic plasticity important in learning and information storage the brain. It has been studied various cortical regions, including anterior cingulate cortex (ACC). ACC crucial region involved such emotion-related physiological pathological conditions as fear memory chronic pain. In present study, we used multielectrode array system to map LTD spatiotemporal manner within ACC. We found that low-frequency stimulation (1 Hz, 15 min) applied onto...
Background Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, mechanisms underlying generation of pain PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model to analyze relationship between sensory abnormalities and degeneration dopaminergic neurons. Results The latency fall off rotarod total distance traveled round chamber were significantly reduced MPTP-induced mice, consistent...
<h3>Background:</h3> Health care workers treating Coronavirus disease 2019 (COVID-19) patients face significant stressors such as caring for critically ill and dying patients, physically demanding requiring new degrees of personal protective equipment use, risk contracting the disease, putting loved ones at risk. This study investigates stress impact from COVID-19 exposure how nurses medical providers (eg, physicians, nurse practitioners, physician assistants) experience these challenges...
One of cannabis' most iconic effects is the stimulation hedonic high-calorie eating-the "munchies"-yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use drug often begins. found that daily low-dose administration intoxicating constituent, Δ
ABSTRACT Peripheral nerve injury resulting in neuropathic pain induces the upregulation of interleukin (IL)‐6 and tumor necrosis factor‐α, which binds to factor receptor 1 (TNFR1) NF‐κB p38 MAPK activation spinal cord dorsal root ganglia (DRG). We here investigated whether TNFR1 regulates IL‐6 expression through or activations DRG rats with chronic constriction (CCI) sciatic nerve. Intrathecal treatment a antisense oligonucleotide (ASO) significantly inhibited CCI‐elevated IKKs...