A5100423754- Cerebrovascular and Carotid Artery Diseases
- Cell Adhesion Molecules Research
- Acute Ischemic Stroke Management
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Cardiac Imaging and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Health and Wellbeing Research
- Digital Holography and Microscopy
- RNA modifications and cancer
- Nutrition, Health and Food Behavior
- T-cell and B-cell Immunology
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- Obesity, Physical Activity, Diet
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Advanced X-ray and CT Imaging
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Veterinary Oncology Research
University of Ulsan
2007-2025
Asan Medical Center
2007-2025
Seoul National University
2014-2024
Korea Research Institute of Chemical Technology
2012-2024
Seoul National University Hospital
2024
St. Mary’s Hospital
2024
Columbia University Irving Medical Center
2024
Chungnam National University
2009-2024
Keimyung University
2007-2024
Inje University Sanggye Paik Hospital
2021-2024
Abstract Background Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated treatment resistance, unfavorable prognosis, infiltration of pro-tumorigenic macrophages. Results We explore regulatory networks mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive malignant phenotypic...
Background Since it was suggested that B cells play a role in the pathogenesis of chronic graft-versus-host disease, rituximab, an anti-CD20 monoclonal antibody targeting cells, has been shown to be effective steroid-refractory, disease. However, most data were from small numbers patients or retrospective analyses. We, therefore, conducted multicenter phase II study confirm efficacy this treatment strategy targets cells.Design and Methods We diagnosed evaluated disease according National...
Two histone marks, H3K27me3 and H3K9me3, are well known for their repressive roles in the genic nongenic regions of metazoan genomes. Several protein complexes to be responsible generating these including polycomb repression complex 2 several H3K9 methylases. Recent studies have shown that targeting histone-modifying within mammalian genomes may mediated through DNA-binding proteins, AEBP2, JARID2, YY1. In this review, we discuss potential mechanisms light recent results been derived from...
Several studies suggest that subjective health status is closely related to various behavioral addictions, but there are few on smartphone overuse.This study investigated the associations between psychological and conditions overuse in Korean college students.A total of 608 students participated this study. We perceived factors, such as stress, depression symptoms suicidal ideation. Overall was evaluated with self-assessed items, including usual condition EuroQol-visual analog scales...
Natural killer/T-cell lymphoma (NKTCL) is a disease with limited treatment options and poor outcomes. Daratumumab monotherapy demonstrated clinical activity in single-patient case report. We present data from the primary analysis of phase 2 study daratumumab relapsed or refractory (R/R) NKTCL.This Simon's two-stage design evaluated patients histologically confirmed extranodal NKTCL, nasal type, per WHO classification that was to after ≥ 1 line chemotherapy, who were not candidates for other...
Abstract The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility. Although recent studies have reported that EGFR signaling is involved osteoclast recruitment formation, the molecular mechanism of for regulation osteoclastogenesis remains unclear. We investigated role differentiation survival show expression was highly up‐regulated by activator nuclear factor‐κB ligand (RANKL) during...
Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated target 1-dehydro-[10]-gingerdione (D10G), one pungent ginger, that mediates its suppression NF-κB-regulated expression genes linked to toll-like receptor (TLR)-mediated innate immunity.
Unclear-onset strokes are generally excluded from time-based thrombolytic therapy. We examined the safety and feasibility of magnetic resonance imaging-based reperfusion therapy in unclear-onset stroke.This prospective, multicenter, single-arm study screened consecutive stroke patients within 6 hours symptom detection. Patients with perfusion-diffusion mismatch>20% negative or subtle fluid-attenuated inversion recovery changes were treated intravenous tissue plasminogen activator,...
Tumor metastasis involves circulating and tumor‐initiating capacities of metastatic cancer cells. Epithelial‐mesenchymal transition (EMT) is related to self‐renewal capacity tumor cell (CTC) characteristics for metastasis. Although a life‐threatening, complicated process that occurs through circulation cells, mechanistic aspects have been largely unknown. Hepatic transmembrane 4 L six family member 5 (TM4SF5) promotes EMT malignant growth migration, so it was rationalized TM4SF5, as...
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OBJECTIVE Diet-induced obesity (DIO) is linked to peripheral insulin resistance—a major predicament in type 2 diabetes. This study aims identify the molecular mechanism by which DIO-triggered endoplasmic reticulum (ER) stress promotes hepatic resistance mouse models. RESEARCH DESIGN AND METHODS C57BL/6 mice and primary hepatocytes were used evaluate role of LIPIN2 ER stress-induced resistance. Tunicamycin, thapsigargin, lipopolysaccharide invoke acute conditions. To promote chronic stress,...
d-allulose is a rare sugar with zero energy that can be consumed by obese/overweight individuals. Many studies have suggested zero-calorie has beneficial effects on obesity-related metabolism in mouse models, but only few been performed human subjects. Therefore, we preliminary study 121 Korean subjects (aged 20–40 years, body mass index ≥ 23 kg/m2). A randomized controlled trial involving placebo control (sucralose, 0.012 g × 2 times/day), low (d-allulose, 4 and high 7 times/day) groups was...
Abstract Melatonin protects against Cadmium (Cd)-induced toxicity, a ubiquitous environmental toxicant that causes adverse health effects by increasing reactive oxygen species (ROS) production and mitochondrial dysfunction. However, the underlying mechanism remains unclear. Here, we demonstrate Cd exposure reduces levels of mitochondrially-localized signal transducer activator transcription 3 (mitoSTAT3) using human prostate stromal cells mouse embryonic fibroblasts. enhances mitoSTAT3...
The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires activation nuclear factor-κB (NF-κB) and consequent up-regulation matrix metalloproteinase-9 (MMP-9). This study was undertaken to test for a possible effect α-lipoic acid (ALA), potent inhibitor NF-κB, on MMP-9 expression. ALA inhibited high-glucose- TNF-α-stimulated VSMC migrations vitro. It also TNF-α-induced increases activity MMP-9-promoter...