A5034533911- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Dysphagia Assessment and Management
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Ion channel regulation and function
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
University Medical Centre Mannheim
2025
Heidelberg University
2025
University Hospital Heidelberg
2025
Wake Forest University
2022
Kangbuk Samsung Hospital
2003-2016
Creative Commons
2015-2016
JCR Pharmaceuticals (Japan)
2015
Multichannel (China)
2015
Although the prognosis for pancreatic cancer is generally poor, it well known that survival rate resected much higher than more conservative treatment. The importance of early detection emphasized resection cancer. Measurement serum carbohydrate antigen (CA) 19-9 has shown satisfactory sensitivity and predictive value in symptomatic patients, but no available data been found on healthy asymptomatic subjects. Thus, authors aimed to determine clinical usefulness CA as a screening tool...
To compare the efficacy of radiofrequency ablation (RFA) and surgical resection in a group patients with Child-Pugh score 5 single HCC less than 4 cm diameter.Radiofrequency has become popular method for treatment hepatocellular carcinoma (HCC) been applied as an alternative primary therapy to resection.We compared outcomes 148 treated RFA (n = 55) those surgically 93).The rate local recurrence among was significantly higher surgery (P 0.005), while incidence remote similar between two...
Abstract Background and Aim: Although increased mast cells in the gut their role visceral hypersensitivity irritable bowel syndrome have been postulated, this relationship remains unclear. Our aim was to determine whether a exists between number of mucosal hypersensitivity. Method: Eighteen patients with diarrhea predominant (D‐IBS) (eight females, 10 males aged 25–65 years; mean 42.6 years) symptoms meeting Rome‐II criteria, 15 healthy controls (five 31–57 41.4 were recruited. Participants...
Abstract Background and Aims: Epidemiologic studies provide evidence for a link between obesity or diabetes the risk colorectal cancer. However, there is lack of information about relationship metabolic syndrome adenoma. Therefore, we investigated whether factor Methods: We did study consecutive subjects who underwent colonoscopy as screening exam at Center Health Promotion, Samsung Medical Center, from March 2004 to December 2005. According modified ATP III criteria, was diagnosed....
Despite the benefits from adjuvant chemotherapy or chemoradiotherapy, approximately one-third of stage II gastric cancer (GC) patients developed recurrences. The aim this study was to develop and validate a prognostic algorithm for (GCPS) that can robustly identify high-risk group recurrence among patients. A multi-step gene expression profiling conducted. First, microarray archived paraffin-embedded tumor blocks used candidate genes (N = 432). Second, focused assay including robust clinical...
Smooth muscle layers of the gastrointestinal tract consist a heterogeneous population cells that include enteric neurons, several classes interstitial mesenchymal origin, variety immune and smooth (SMCs). Over last number years complexity interactions between these cell types has begun to emerge. For example, cells, consisting both Cajal (ICC) platelet-derived growth factor receptor alpha-positive (PDGFRα(+)) generate pacemaker activity throughout (GI) also transduce motor nerve signals...
Hiroto Miwa, Uday C Ghoshal, Sutep Gonlachanvit, Kok-Ann Gwee, Tiing-Leong Ang, Full-Young Chang, Kwong Ming Fock, Michio Hongo, Xiaohua Hou, Udom Kachintorn, Meiyun Ke, Kwok-Hung Lai, Kwang Jae Lee, Ching-Liang Lu, Sanjiv Mahadeva, Soichiro Miura, Hyojin Park, Poong-Lyul Rhee, Kentaro Sugano, Ratha-korn Vilaichone, Benjamin CY Wong and Young-Tae Bak. J Neurogastroenterol Motil 2012;18:150-68. https://doi.org/10.5056/jnm.2012.18.2.150
Summary Background The risk of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor (PPI) use has been raised in cirrhotic patients ascites. However, this is based on case–control studies, often a small series. Aim To determine whether PPI increases the SBP using large cohort. Methods This retrospective cohort study included 1965 ascites diagnosed between January 2005 and December 2009. incidence rate was compared non‐PPI groups before after propensity score matching...
Summary Background Tegoprazan is a novel potassium‐competitive acid blocker that has fast onset of action and can control gastric pH for prolonged period, which could offer clinical benefit in acid‐related disorders. Aim To confirm the non‐inferiority tegoprazan to esomeprazole patients with erosive oesophagitis (EE). Methods In this multicentre, randomised, double‐blind, parallel‐group comparison study, 302 Korean endoscopically confirmed EE (Los Angeles Classification Grades A‐D) were...
To suggest an appropriate surveillance strategy after curative endoscopic submucosal dissection (ESD) for early gastric cancers, based on incidence and patterns of local, metachronous, extragastric recurrence.Between 2003 2011, 1497 consecutive patients with 1539 differentiated-type cancers meeting absolute or expanded indication criteria underwent ESD. They were followed up esophagogastroduodenoscopy (EGD) abdominal computed tomography (CT) under a standardized protocol. Long-term outcomes...
Abstract Background and Aims : Ulcerative colitis (UC) is regarded as a rare disease in developing countries, but accurate data are generally lacking. We performed the present study to evaluate incidence prevalence of UC Korea. Methods A retrospective was from 1986 1997 Songpa‐Kangdong district Seoul, To recruit patients completely possible, multiple information sources including all medical facilities area three referral centres located nearby, outside were used. The rates adjusted using...
ㅋMeasurement of colon transit time is the most basic and primary tool in evaluating disorders colonic motility.In particular, it helpful pathologic diagnosis for planning management patients with constipation.Several techniques measuring currently exist.The standard measurement has been performed using radioopaque marker test.The test widely used method; simple to perform as well being cost effective.But, this technique produces radiation exposure.Radionuclide scintigraphy wireless motility...
Abstract To investigate whether Helicobacter pylori ( HP) infection affects the clinical response to levodopa and its eradication could improve motor fluctuation in patients with Parkinson's disease (PD). Using [ 13 C] urea breath test, we monitored HP 65 PD fluctuations of “wearing‐off” or delayed “on” types, without dyskinesia. We compared features L ‐dopa between noninfected (n = 30) infected 35) by reviewing home diaries kept for 72 hours. Among patients, differences “onset” time,...
Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen colonoscopy.A total 232 patients were randomly assigned receive 4 liters PEG (day before procedure; group 1, n=79), 2 procedure) followed by another 2, n=80), or citrate (250 ml, day 3, n=73). quality bowel cleansing, tolerability, adverse effects in 3 compared with those groups 1...
This study evaluated the significance of cystic fluid analysis and radiologic findings in differential diagnosis biliary cystadenomas (BCA) hepatic simple cysts (HSCs).BCA are premalignant lesions. The treatment choice is surgical excision. It important to differentiate BCA from HSCs because they have different clinical significances plans. However, it difficult preoperatively a HSC.This retrospective was done with 31 patients suffering pathologically diagnosed or HSC. All underwent surgery...
Environmental factors such as food, lifestyle and prevalence of Helicobacter pylori infection are widely different in Asian countries compared with the West, physiological functions genetic Asians may also be from those Westerners. Establishing an consensus for functional dyspepsia is crucial order to attract attention data countries, articulate experience views experts, provide a relevant guide on management primary care physicians working Asia.Consensus team members were selected experts...
Esophageal hypersensitivity is currently believed to have a crucial role in the pathogenesis of functional chest pain (FCP). The aim this study was evaluate clinical efficacy venlafaxine, serotonin-norepinephrine reuptake inhibitor (SNRI), for FCP young adult patients.Patients diagnosed with were randomized either an extended-release formulation venlafaxine (75 mg hora somni) or placebo 4 weeks. After washout period 2 weeks, patients crossed over other arm study. primary variable number >50%...
Extracellular electrical recording and studies using animal models have helped establish important concepts of human gastric physiology. Accepted standards include quiescence in the fundus, 3 cycles per minute (cpm) pacemaker activity corpus antrum, a proximal-to-distal slow wave frequency gradient. We investigated activity, contractions distribution interstitial cells Cajal (ICC) muscles. Muscles were obtained from patients undergoing resection for cancer, anatomical locations each specimen...
There is suggestive but sparse evidence that dyslipidemia associated with colorectal neoplasms. We investigated the association of serum lipid and apolipoprotein concentrations prevalence adenomas.Cross-sectional study 19,281 consecutive participants aged 40-79 years undergoing screening colonoscopy at Center for Health Promotion Samsung Medical in Korea from January 2006 to June 2009.We identified 5,958 adenomas (30.9%), including 5,504 (28.5%) non-advanced 454 (2.4%) advanced adenomas. The...