A5017268309- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- COVID-19 epidemiological studies
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Colorectal Cancer Screening and Detection
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Vaccine Coverage and Hesitancy
- Genetic factors in colorectal cancer
- Healthcare professionals’ stress and burnout
- COVID-19 and Mental Health
- Diabetes Management and Education
- Workplace Violence and Bullying
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Health and Well-being Studies
- Job Satisfaction and Organizational Behavior
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Reforms
- Organ Donation and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Malaria Research and Control
University of Malaya
2015-2024
Sultan Abdul Halim Hospital
2023
Indraprastha Apollo Hospitals
2023
Johns Hopkins University
2012-2017
Kangbuk Samsung Hospital
2014-2016
Sungkyunkwan University
2014-2016
Bloomberg (United States)
2015
Samsung Medical Center
2014-2015
Johns Hopkins Medicine
2014-2015
Samsung (South Korea)
2014
Background: The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. Objective: To investigate the incident CKD across categories of body mass index in a large cohort men and women. Design: Prospective study. Setting: Kangbuk Samsung Health Study, Hospital, Seoul, South Korea. Participants: 62 249 healthy, young middle-aged women or proteinuria at baseline. Measurements:...
The risk of nonalcoholic fatty liver disease (NAFLD) among obese individuals without obesity-related metabolic abnormalities, a condition referred to as metabolically healthy (MHO), is largely unexplored. Therefore, we examined the association between body mass index (BMI) categories and development NAFLD in large cohort men women.A study was conducted 77,425 women free abnormalities at baseline, who were followed-up annually or biennially for an average 4.5 years. Being defined not having...
Introduction The prevalence of metabolic syndrome is increasing disproportionately among the different ethnicities in Asia compared to rest world. This study aims determine differences across Malaysia, a multi-ethnic country. Methods In 2004, we conducted national cross-sectional population-based using stratified two-stage cluster sampling design (N = 17,211). Metabolic was defined according International Diabetes Federation/National Heart, Lung and Blood Institute/American Heart Association...
Background: Overt and subclinical hypothyroidism are associated with higher levels of serum creatinine increased risk chronic kidney disease (CKD). The prospective association between thyroid hormones function in euthyroid individuals, however, is largely unexplored. Methods: We conducted a cohort study 104 633 South Korean men women who were free CKD proteinuria at baseline had normal hormone no history or cancer. At each annual biennial follow-up visit, thyroid-stimulating (TSH),...
The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility non-alcoholic fatty liver disease (NAFLD) in various cohorts. We further investigated the association of this steatohepatitis (NASH) severity and histological features NAFLD. A total 144 biopsy-proven NAFLD patients 198 controls were genotyped for PNPLA3 gene (rs738409 C>G). biopsy specimens histologically graded by a qualified pathologist. observed an G allele pooled subjects (OR 2.34, 95% CI...
There is suggestive but sparse evidence that dyslipidemia associated with colorectal neoplasms. We investigated the association of serum lipid and apolipoprotein concentrations prevalence adenomas.Cross-sectional study 19,281 consecutive participants aged 40-79 years undergoing screening colonoscopy at Center for Health Promotion Samsung Medical in Korea from January 2006 to June 2009.We identified 5,958 adenomas (30.9%), including 5,504 (28.5%) non-advanced 454 (2.4%) advanced adenomas. The...
Short and long sleep duration are associated with increased risk of clinical cardiovascular events, but the association between subclinical disease is not well established. We examined quality coronary artery calcification (CAC) brachial-ankle pulse wave velocity (PWV) in a large sample young middle-aged asymptomatic adults. conducted cross-sectional study adult men women who underwent health checkup examination, including assessment coupled either CAC (n=29 203) or PWV (n=18 106). The...
Introduction Guidelines for management of non-small cell lung cancer (NSCLC) strongly recommend EGFR mutation testing. These recommendations are particularly relevant in Asians that have higher prevalence. This study aims to explore current testing practices, logistics testing, types mutation, and prevalence mutations patients with advanced NSCLC a large comprehensive center Korea. Methods Our retrospective cohort included 1,503 aged ≥18 years, stage IIIB/IV disease, who attended the Samsung...
Enterovirus A71 (EV-A71) is an important emerging pathogen causing large epidemics of hand, foot and mouth disease (HFMD) in children. In Malaysia, since the first EV-A71 epidemic 1997, recurrent cyclical have occurred every 2–3 years for reasons that remain unclear. We hypothesize this pattern due to changes population immunity children (measured as seroprevalence). Neutralizing antibody titers against were measured 2,141 residual serum samples collected from ≤12 old between 1995 2012...
COVID-19 has rapidly spread across the globe. Critical to control of is characterisation its epidemiology. Despite this, there been a paucity evidence from many parts world, including Malaysia. We aim describe epidemiology in Malaysia inform prevention and policies better.
Abstract Hemorrhoidal disease is a highly prevalent anorectal condition causing substantial discomfort, disability, and decreased quality of life. Evidence on preventable risk factors for hemorrhoidal limited. We conducted cross-sectional study 194,620 healthy men women who completed health screening exam including colonoscopy in 2011–2017. evaluated potential disease, lifestyle factors, medical history, birth gastrointestinal symptoms, anthropometric measurements. The prevalence was 16.6%,...
Abstract Background There is limited data on the nutritional status of Asian patients with various aetiologies cirrhosis. This study aimed to determine prevalence malnutrition and compare differences between aetiologies. Methodology A cross-sectional adult decompensated cirrhosis was conducted. Nutritional assessed using standard anthropometry, serum visceral proteins subjective global assessment (SGA). Results Thirty six (mean age 59.8 ± 12.8 years; 66.7% males; 41.6% viral hepatitis;...
The role of ethnicity in the development dyspepsia remains uncertain.To examine epidemiology a multi-ethnic Asian population and its impact on health-related quality life (HRQOL).A cross-sectional survey was conducted representative urban Kuala Lumpur, Malaysia.A total 2039 adults (mean +/- s.d. age: 40.5 11.8 years, males 44.2%, ethnicity: Malays 45.3%, Chinese 38.0% Indians 13.1%, tertiary education level 62%, professional employment 47.7% median monthly income USD 850.00) were...
The role of hepatitis virus infection in glucose homeostasis is uncertain. We examined the associations between B (HBV) or C (HCV) and development diabetes a cohort (N = 439,708) asymptomatic participants health screening examinations. In cross-sectional analyses, multivariable-adjusted odds ratio for prevalent comparing surface antigen (HBsAg) (+) to HBsAg (-) was 1.17 (95% CI 1.06-1.31; P 0.003). corresponding antibodies (HCV Ab) HCV Ab 1.43 1.01-2.02, 0.043). prospective hazard incident...
Hyperthyroidism and hypothyroidism, both overt subclinical, are associated with all-cause cardiovascular mortality. The association between thyroid hormones mortality in euthyroid individuals, however, is unclear.To examine the prospective levels within normal ranges endpoints.A cohort study of 212 456 middle-aged South Korean men women who had hormone no history disease at baseline from January 1, 2002 to December 31, 2009. Free T4 (FT4), free T3 (FT3), TSH were measured by RIA. Vital...
OBJECTIVES: The epidemiology and impact of dyspepsia in rural Asia remains uncertain. We aimed to determine the prevalence a Malaysian community. METHODS: A door-to-door survey was conducted representative population Malaysia. Dyspepsia defined according Rome II criteria, health-related quality life (HRQOL) assessed using Euroqol (EQ-5D) instrument. RESULTS: Of 2,260 adults, 2,000 (88.5%) completed survey. mean age respondents 40.4±15.3 years, 62.7% were women, 79.0% ethnic Malays, 8.4% had...
Overt and subclinical hypothyroidism are risk factors for atherosclerosis. It is unclear whether thyroid hormone levels within the normal range also associated with atherosclerosis measured by coronary artery calcium (CAC).We conducted a cross-sectional study of 41 403 apparently healthy young middle-aged men women levels. Free thyroxin, free triiodothyronine, thyroid-stimulating were electrochemiluminescent immunoassay. CAC score was multidetector computed tomography. The multivariable...