A5103253535- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Diseases and Glomerulopathies
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Renal function and acid-base balance
- Nutritional Studies and Diet
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Liver Disease Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Diverse Approaches in Healthcare and Education Studies
- Diabetes Treatment and Management
- Renin-Angiotensin System Studies
- Renal and related cancers
- Adipose Tissue and Metabolism
- Health and Wellbeing Research
Sungkyunkwan University
2016-2025
Kangbuk Samsung Hospital
2016-2025
Yonsei University
2021-2025
Pediatric Nephrology of Alabama
2020
Samsung Medical Center
2015-2020
Johns Hopkins University
2016
University of Malaya
2016
Korea University
2010-2013
Ansan University
2012
Korea University Medical Center
2011
Background: The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. Objective: To investigate the incident CKD across categories of body mass index in a large cohort men and women. Design: Prospective study. Setting: Kangbuk Samsung Health Study, Hospital, Seoul, South Korea. Participants: 62 249 healthy, young middle-aged women or proteinuria at baseline. Measurements:...
Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins cause toxicological renal effects at high levels, but the relevance of low-level environmental exposures in general population is controversial. A total 1,797 adults who participated KNHANES (a cross-sectional nationally representative survey Korea) were examined, 128 them (7.1%) had chronic kidney disease (CKD). Our study assessed association between Pb, Hg, Cd exposure, CKD. Blood Pb levels correlated with CKD...
The NF-κB pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, has also been suggested as mechanism linking obesity, inflammation, metabolic disorders. However, there is no current evidence regarding the of action inhibition insulin resistance diabetic nephropathy type 2 animal models. We investigated effects inhibitor celastrol db/db mice. treatment with for months significantly lowered fasting plasma glucose (FPG), HbA1C homeostasis model assessment...
Despite the emerging importance of fibroblast growth factor 21 (FGF21) as a metabolic hormone regulating energy balance, its direct effects on renal function remain unexplored. FGF21 was injected ip daily for 12 weeks into db/db mice. Compared with control vehicle injection, treatment significantly improved lipid profiles and insulin resistance resulted in higher serum adiponectin levels. In contrast, 8-isoprostane levels were decreased. Interestingly, receptor components kidneys found to be...
The endocannabinoid system is important in the pathogenesis of obesity-related metabolic disorders. However, effect inhibiting type 2 diabetic nephropathy unclear. Therefore, we examined cannabinoid (CB)1 receptor antagonist, SR141716, on insulin resistance and db/db mice. Six-week-old mice were treated with CB1-specific antagonist SR141716 (10 mg/kg·d) for 3 months. Treatment significantly improved lipid abnormalities. Concomitantly, CB1 antagonism cardiac functional morphological...
Abstract Chronic inflammation caused by high glucose and free fatty acid (FFA) concentrations is a major contributor to the pathogenesis of type 2 diabetes. Recent evidence suggests that activation Toll-like receptor (TLR) signaling induces peripheral insulin resistance mediates central leptin resistance. In this study, we investigated renal effects TLR4 blockade in diabetic mice. Eight-week-old db/db mice were treated for 12 weeks with (S,R)-3-phenyl-4,5-dihydro-5-isoxasole acetic (GIT27),...
In response to the increase in prevalence of chronic kidney disease (CKD) Korea, growth patients requiring renal replacement therapy and subsequent medical costs, rapid expansion with end-stage (ESKD), decrease receiving home therapy, including peritoneal dialysis, Korean Society Nephrology has proclaimed new policy, Kidney Health Plan 2033 (KHP 2033). KHP would serve as a milestone bridge current issues future solution by directing prevention progression CKD ESKD, particularly diabetic...
Adverse changes in nutrition are prevalent and strong indicators of adverse outcomes patients with chronic kidney disease (CKD). The International Society Renal Nutrition Metabolism (ISRNM) proposed a common nomenclature diagnostic criteria to identify protein-energy wasting (PEW) CKD patients. We examined the nutritional status 1,834 adults predialysis enrolled KoreaN cohort study for Outcome With Chronic Kidney Disease (KNOW-CKD) study. As there was need further understanding associated...
Abstract Background Diet is a modifiable factor of chronic kidney disease (CKD) progression. However, the effect dietary salt intake on CKD progression remains unclear. Therefore, we analyzed renal outcome in Korean patients with CKD. Methods We measured 24-h urinary sodium (Na) excretion as marker prospective, multi-center, longitudinal KoreaN cohort study for Outcome With (KNOW-CKD). Data were from at Stages G3a to G5 (n = 1254). investigated association between and Patients divided into...
The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was developed to investigate various clinical courses and risk factors progression of Korean chronic kidney disease (CKD). KNOW-CKD study consists nine centers Korea, patients aged between 20 75 years with CKD from stage 1 5 (predialysis) were recruited. At baseline, blood urine samples obtained demographic data including comorbidities, drugs, quality life, health behaviors collected. Estimated glomerular...
Dietary net endogenous acid production (NEAP), which represents total dietary load of nonvolatile acid, may affect kidney function. Estimated NEAP (eNEAP) is calculated indirectly by the ratio protein and potassium intake. A few studies are available assessing association between eNEAP chronic disease (CKD), its relation to intake in elderly.A 1,369 community-dwelling elderly Koreans Kangbuk Samsung Cohort Study (KSCS) were evaluated using a food frequency questionnaire (FFQ) comprehensive...
It is unclear whether sleep duration and quality are associated with chronic kidney disease (CKD) glomerular hyperfiltration. The aim of this study was to examine the association CKD hyperfiltration in young middle-aged adults.We conducted a cross-sectional men women who underwent health checkup examination, including assessment (n = 241,607). Chronic defined as an estimated filtration rate (eGFR) less than 60 ml/min/1.73 m2, eGFR above age-/sex-specific 95th percentile.In multinomial...
There are no clear data to support the cardiovascular (CV) risk categories and low-density lipoprotein cholesterol (LDL-C) treatment goals in Korean people with type 2 diabetes mellitus (T2DM). We evaluated incidence of disease (CVD) according comorbidities suggested LDL-C T2DM nationwide cohort data. Using National Health Insurance Service database, 248,002 aged 30 90 years who underwent routine health check-ups during 2009 were included. Subjects previous CVD excluded from study. The...
Abstract Aim Previous studies have shown that fenofibrate improves outcomes such as albuminuria and estimated glomerular filtration rate decline. We hypothesize has renoprotective effects prevents or delays the development of end‐stage renal disease. The objective this study is to investigate risk incident disease in relation treatment patients who are already taking statins. Materials Methods performed a nationwide population‐based cohort using data from Korea National Health Information...
Background/Objectives: This study examined the effects of alcohol consumption on chronic kidney disease (CKD) risk in community-dwelling older adults. Methods: A nationwide retrospective observational was conducted using NHIS-Senior cohort data (2009–2018). Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) 60 mL/min/1.73 m2 were included. Alcohol classified as non-drinking, mild, moderate, or heavy drinking. CKD onset defined eGFR < m2. Results: Of 122,319...
Early mortality following hemodialysis initiation hinders survival improvement in older patients. This study aimed to develop a clinical risk model for predicting 6-month after dialysis Korean We analyzed data from incident patients aged >70 years the Society of Geriatric Nephrology (KSGN) database. A prediction was developed using multivariate logistic regression analysis and externally validated with independent datasets. Among 1,751 patients, rate 15.5%. Using analysis, we constructed...
Abstract Dibenzooxasiline‐derived compounds, 2,4‐bis(10,10‐diphenyl‐10H‐dibenzo[b,e][1,4]oxasilin‐2‐yl)‐6‐phenyl‐1,3,5‐triazine (mOSiTrz) and 9‐(4,6‐bis(10,10‐diphenyl‐10H‐dibenzo[b,e][1,4]oxasilin‐2‐yl)‐1,3,5‐triazin‐2‐yl)‐9H‐carbazole (mOSiCzTrz), are developed as high‐triplet‐energy n ‐type hosts for blue phosphorescent organic light‐emitting diodes (PhOLEDs). They used in a mixed host to assist positive‐polaron dispersion the p–n achieve high efficiency long device lifetime. The...
Background. Aliskiren is a direct renin inhibitor (DRI) and provides an organ-protective effect in human animal experiments. However, there no current evidence of the DRI on insulin resistance metabolic abnormalities type 2 diabetic animals.