A5023097709- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Xenotransplantation and immune response
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Pediatric Urology and Nephrology Studies
- Genetic Syndromes and Imprinting
- Animal Genetics and Reproduction
- Liver Disease Diagnosis and Treatment
- Renal function and acid-base balance
- Immune Cell Function and Interaction
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Biomedical Research and Pathophysiology
- Organ and Tissue Transplantation Research
- Blood Pressure and Hypertension Studies
- T-cell and B-cell Immunology
National Medical Center
2021-2025
Seoul National University
2016-2025
University of Cincinnati Medical Center
2025
Yonsei University
2000-2024
New Generation University College
2009-2024
Seoul National University Hospital
2014-2023
National University College
2000-2023
The Radiosurgery Society
2023
Ewha Womans University
2023
MetroWest Medical Center
2023
Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of pluripotent embryonic stem (ES) line (SCNT-hES-1) from cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES morphology and surface markers were capable differentiating into embryoid bodies in vitro forming teratomas vivo containing derivatives all three germ layers severe combined immunodeficient mice. After...
Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to be of great biomedical importance for studies disease and development advance clinical deliberations regarding cell transplantation. Eleven hESC lines were established by somatic nuclear transfer (SCNT) skin from patients with or injury into donated oocytes. These lines, (NT)-hESCs, grown on feeders the same NT donor genetically unrelated individuals, at high rates, regardless sex age. NT-hESCs...
Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins cause toxicological renal effects at high levels, but the relevance of low-level environmental exposures in general population is controversial. A total 1,797 adults who participated KNHANES (a cross-sectional nationally representative survey Korea) were examined, 128 them (7.1%) had chronic kidney disease (CKD). Our study assessed association between Pb, Hg, Cd exposure, CKD. Blood Pb levels correlated with CKD...
The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), albuminuria (A). KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease), which is a prospective cohort study, enrolls subjects with stages 1 to 5 (predialysis). Nine nephrology centers major university hospitals throughout Korea will enroll approximately 2,450 adults over 5-year period from 2011 2015. participating...
Urinary tract infection (UTI) occurs in 30%-50% of individuals with autosomal dominant polycystic kidney disease (ADPKD). However, the clinical relevance asymptomatic pyuria ADPKD patients remains unknown.We retrospectively reviewed medical records 256 who registered to clinic at Seoul National University Hospital from Aug 1999 2010. We defined as more than 5-9 white blood cells high-power field no related symptoms or signs overt UTI. Patients were categorized into 2 groups depending on its...
Abstract The prevalence of hyperuricemia and chronic kidney disease (CKD) has been steadily increasing. role efficacy uric acid-lowering agents against CKD progression remain controversial. This study aimed to evaluate the effect on CKD. A total 2042 patients with were analyzed in KoreaN cohort Study for Outcomes With Chronic Kidney Disease (KNOW-CKD), a prospective study. Patients classified into quartiles basis their serum acid level advanced was higher high level. composite renal outcome...
BACKGROUND: It is unclear whether intraoperative arterial hypotension associated with postoperative delirium. We hypothesized that within a range frequently observed in clinical practice increased odds of delirium after surgery. METHODS: Adult noncardiac surgical patients undergoing general anesthesia at 2 academic medical centers between 2005 and 2017 were included this retrospective cohort study. The primary exposure was hypotension, defined as the cumulative duration an mean pressure...
Background The incidences of atrial fibrillation (AF) and chronic kidney disease (CKD) are increasing, AF is prevalent in patients with CKD. However, few studies have investigated the incidence or association a large CKD population from longitudinal study. Methods Results From nationwide cohort, total 4 827 987 Korean individuals without prior AF, who received biennial health checkups provided by National Health Insurance Service between 2009 2012 Korea, were analyzed. Incidence was...
Background In recent years, laboratory and clinical research has suggested the need for peritoneal dialysis fluids (PDFs) that are more biocompatible than conventional PDFs commonly used today. Bioincompatibility of PDF been attributed to low pH, lactate, glucose, glucose degradation products (GDPs), osmolality. with neutral pH GDPs now available commercially. vitro early studies suggest these solutions indeed but, as now, there is no evidence their use improves patient outcome. Methods...
Background.In vitro studies of peritoneal dialysis (PD) solutions demonstrated that a biocompatible fluid with neutral-pH and low glucose degradation products (LF) has better biocompatibility than conventional acidic lactate-buffered (CF). However, few clinical trials have investigated the effects solution on residual renal function (RRF). We performed prospective, randomized trial patients starting continuous ambulatory (CAPD).
Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion injury (IRI), but the isolation and ex vivo expansion of these for clinical application remains challenging. Here, we investigated whether IL-2/anti-IL-2 complex (IL-2C), a mediator Treg expansion, attenuate IRI mice. IL-2C administered before bilateral induced both spleen kidney, improved function, attenuated histologic apoptosis after IRI. Furthermore, administration reduced expression inflammatory...
REPORT (d) transgenic pig facilities; (e) biomaterials and encapsulation; (f) immunosuppression tolerance induction.The guidance document from the Second Global Consultation (Geneva, 2011) was also included in these discussions.
Abstract Introduction In patients with chronic kidney disease (CKD), studies investigating the association between smoking and deterioration of function are scarce. Aims Methods We analyzed data for 1,951 an estimated glomerular filtration rate (eGFR) ≥15 mL/min/1.73 m2 enrolled in KoreaN cohort study Outcome With Chronic Kidney Disease (KNOW-CKD) from 2011 to 2016. Patients were categorized by load. Primary outcome was a composite ≥50% reduction eGFR, initiation dialysis, or...