A5058144503- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Meningioma and schwannoma management
- Parkinson's Disease Mechanisms and Treatments
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Transcranial Magnetic Stimulation Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Botulinum Toxin and Related Neurological Disorders
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Chemical Reactions and Isotopes
- Lung Cancer Treatments and Mutations
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Research Studies
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
Advanced Institute of Convergence Technology
2017-2025
Soonchunhyang University
2023-2024
National University College
2006-2023
New Generation University College
2006-2023
University of Minnesota
2023
Weatherford College
2023
Clinical Research Institute
2008-2020
Seoul National University of Science and Technology
2020
Abstract Brain metastases are associated with a dismal prognosis. Whether brain harbor distinct genetic alterations beyond those observed in primary tumors is unknown. We performed whole-exome sequencing of 86 matched metastases, tumors, and normal tissue. In all clonally related cancer samples, we branched evolution, where metastatic sites shared common ancestor yet continued to evolve independently. 53% cases, found potentially clinically informative the not detected primary-tumor sample....
Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to be of great biomedical importance for studies disease and development advance clinical deliberations regarding cell transplantation. Eleven hESC lines were established by somatic nuclear transfer (SCNT) skin from patients with or injury into donated oocytes. These lines, (NT)-hESCs, grown on feeders the same NT donor genetically unrelated individuals, at high rates, regardless sex age. NT-hESCs...
OBJECTIVE: Patients with brain metastases were analyzed retrospectively to assess the risks and benefits of surgery modern neurosurgical techniques, including image guidance coupled as indicated corticography. METHODS: We charts patients treated surgically for metastases. identified single or multiple who underwent craniotomies reverse associated neurological symptoms establish a diagnosis. assessed according recursive partitioning analysis (RPA) prognostic groups well functional grades...
Object. Rathke cleft cysts (RCCs) are rarely symptomatic. The purpose of this study was to clarify the clinical, neuroimaging, surgical, and pathological features symptomatic RCCs with special attention their recurrence. Methods. This retrospective involved 53 patients pathologically confirmed RCCs. There were 28 female 25 male patients, ranging in age from 11 68 years (mean 37 years). Common clinical presentations included headache, visual impairment, endocrine disturbance. most common...
To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, authors used a prospective study design analyze these patients.Between December 1997 January 2002, 25 schwannoma serviceable were enrolled current study. The median tumor volume was 3.0 cc (0.16-9.1 cc). prescription dose 12.0 +/- 0.7 gray at an isodose line of 49.8 1.1%. control complications evaluated by focusing on...
Calcium signaling is important in many processes cancer cell proliferation and motility including deadly glioblastomas of the brain that aggressively invade neighboring tissue. We hypothesized disturbing Ca(2+) pathways might decrease invasive behavior giloblastoma, extending survival. Evaluating a panel small-molecule modulators signaling, we identified caffeine as an inhibitor glioblastoma motility. Caffeine, which known to activate ryanodine receptors, paradoxically inhibits increase by...
A challenge associated with deep brain stimulation (DBS) in treating advanced Parkinson disease (PD) is the direct visualization of nuclei, which often involves indirect approximations stereotactic targets. In present study, authors compared T2*-weighted images obtained using 7-T MR imaging those 1.5- and 3-T to ascertain whether enables better targets for DBS PD.
Dopaminergic degeneration is a pathologic hallmark of Parkinson's disease (PD), which can be assessed by dopamine transporter imaging such as FP-CIT SPECT. Until now, has been routinely interpreted human though it show interobserver variability and result in inconsistent diagnosis. In this study, we developed deep learning-based SPECT interpretation system to refine the diagnosis disease. This trained images PD patients normal controls shows high classification accuracy comparable with...
Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high efficacy compared conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at biological safe range magnetic field (Happl ·fappl < 3.0-5.0 × 109 A m-1 s-1 ), highly required biocompatibility superparamagnetic nanoparticle (SPNP) agents are still remained critical challenges for successful clinical...
Vascular inflammation is characteristic feature of diabetic retinopathy. In retina, a variety the pro-inflammatory cytokines are elevated and involved in endothelial dysfunction. STAT3 transcription factor has been implicated mediating cytokine signaling during vascular inflammation. However, whether how direct regulation permeability currently undefined. Our studies revealed that IL-6-induced activation increases retinal leakage retinas mice through reduced expression tight junction...
Calcium (Ca2+) signaling is an important process, implicated in cancer cell proliferation and motility of the deadly glioblastomas that aggressively invade neighboring brain tissue. We have previously demonstrated caffeine blocks glioblastoma invasion extends survival by inhibiting Ca2+ release channel inositol 1,4,5-trisphosphate receptor (IP3R) subtype 3. Trifluoperazine (TFP) FDA-approved antipsychotic drug for schizophrenia. Interestingly, TFP has been recently reported to show a strong...
Abstract Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas response therapeutic pressure, we performed an epigenomic analysis 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) IDH-mutant (IDHmut) IDHwt showed a stable epigenome over time relatively low levels global methylation. The IDHmut high genome-wide DNA methylation that was progressively reduced similar those...
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal 8,060 newly diagnosed primary cancers, untreated metastases heavily pretreated tumors. The ecDNAs were at significantly higher frequency metastatic tumors compared to cancers. Tumors from chemotherapy-pretreated patients showed ecDNA In particular, tubulin inhibition associated with increases, suggesting a for treatment response. longitudinally matched tumor samples,...
In isocitrate dehydrogenase wildtype glioblastoma (GBM), cellular heterogeneity across and within tumors may drive therapeutic resistance. Here we analyzed 121 primary recurrent GBM samples from 59 patients using single-nucleus RNA sequencing bulk tumor DNA to characterize transcriptional heterogeneity. First, GBMs can be classified by their broad composition, encompassing malignant nonmalignant cell types. Second, in each type describe the diversity of states pathway activation,...
The evolution of isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) after standard-of-care therapy remains poorly understood. Here we analyzed matched primary and recurrent GBMs from 59 patients using single-nucleus RNA sequencing bulk DNA sequencing, assessing the longitudinal GBM ecosystem across layers cellular molecular heterogeneity. most consistent change was a lower malignant cell fraction at recurrence reciprocal increase in glial neuronal types tumor microenvironment (TME)....