A5100352943- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- RNA modifications and cancer
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- TGF-β signaling in diseases
- Congenital heart defects research
- Cancer-related Molecular Pathways
- Adrenal Hormones and Disorders
- Bioinformatics and Genomic Networks
Sungkyunkwan University
2017-2025
Jackson Laboratory
2016-2023
Chonnam National University
2023
Pusan National University
2023
Convergence
2022
Farmington Community Library
2021
Yale University
2013-2019
Pusan National University Yangsan Hospital
2018
The University of Texas MD Anderson Cancer Center
2012-2017
Samsung Medical Center
2017
Infiltrating stromal and immune cells form the major fraction of normal in tumour tissue not only perturb signal molecular studies but also have an important role cancer biology. Here we describe 'Estimation STromal Immune MAlignant Tumours using Expression data' (ESTIMATE)—a method that uses gene expression signatures to infer samples. ESTIMATE scores correlate with DNA copy number-based purity across samples from 11 different types, profiled on Agilent, Affymetrix platforms or based RNA...
Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in typically fatal recurrence ∼7 mo after diagnosis. Understanding the molecular architecture this critical for development successful therapies. We used whole-genome sequencing whole-exome multiple sectors from primary paired recurrent GBM tumors reconstruct genomic profile residual, therapy resistant initiating...
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes increase the proliferation and clonogenicity tumor-initiating glioma stem-like (GSC). This event leads to significantly greater tumor burden decreased host survival compared with untreated GSCs orthotopic xenografts. Analysis exosomal content miR-1587 as...
Abstract Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade gliomas. The O-6-methylguanine-DNA methyltransferase (MGMT) responsible direct repair main TMZ-induced toxic DNA adduct, O6-Methylguanine lesion. MGMT promoter hypermethylation currently only known biomarker TMZ response patients. Here we show that subset recurrent gliomas carries genomic rearrangements lead...
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution single-cell copy number across patient tissues and cell line models observed how cell-to-cell frequency varies greatly. The exceptional intratumoral heterogeneity suggested ecDNA-specific replication propagation mechanisms. To evaluate transfer genetic material from parental to offspring cells during mitosis, we...
Abstract Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, is associated with poor outcomes for patients cancer 1–6 . At present, it unclear whether ecDNA a later manifestation genomic instability, or can be an early event in transition from dysplasia cancer. Here, better understand development ecDNA, we analysed whole-genome sequencing (WGS) data oesophageal adenocarcinoma (EAC) Barrett’s oesophagus. These included 206...
Despite extensive research, the details of biological mechanisms by which cancer cells acquire motility and invasiveness are largely unknown. This study identifies an invasion associated gene signature shedding light on these mechanisms.We analyze data from multiple cancers using a novel computational method identifying sets genes whose coordinated overexpression indicates presence particular phenotype, in this case high-stage cancer.We conclude that there is one shared "core"...
Parry-Romberg disease is a rare condition that results in progressive hemifacial atrophy, involving the skin, dermis, subcutaneous fat, muscle, and, finally, cartilage and bone. Patients have been treated with dermofat or fat grafts by microvascular free flap transfer. We hypothesized adipose-derived stem cells (ASCs) may improve of microfat grafting through enhancing angiogenesis. evaluated utility ASC patients measuring change volumes after injection ASCs alone.In April 2008, this...
Cediranib directly suppresses homology-directed DNA repair in tumor cells and confers synthetic lethal vulnerability to PARP inhibitors.
Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that can potentially maintain or enhance the stem cell phenotype of both normal cells and cancer cells. However, it remains to be determined whether fate regulated in vivo by hypoxic tumor microenvironment (TME). We established a hypoxia-sensing xenograft model identify primarily using human breast lines MDA-MB-231 MCF7. Hypoxic were identified situ fluorescence green protein....
Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category.We assembled gene expression profiles sample annotation 374 patients carrying the 1p/19q co-deletion. We predicted status using when was missing. A first cohort randomly split into training (n = 170) validation dataset 163). second set consisted 41 profiles. An elastic-net penalized Cox proportional hazards...
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared molecular profiles of canine with those human pediatric adult to characterize evolutionarily conserved mammalian mutational processes gliomagenesis. Employing whole-genome, exome, transcriptome, methylation sequencing 83 gliomas, we found alterations shared such as receptor tyrosine kinases, TP53 cell-cycle pathways, IDH1 R132. Canine showed high similarity...
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal 8,060 newly diagnosed primary cancers, untreated metastases heavily pretreated tumors. The ecDNAs were at significantly higher frequency metastatic tumors compared to cancers. Tumors from chemotherapy-pretreated patients showed ecDNA In particular, tubulin inhibition associated with increases, suggesting a for treatment response. longitudinally matched tumor samples,...