A5052723953- Veterinary Oncology Research
- Glioma Diagnosis and Treatment
- Microbial infections and disease research
- Hedgehog Signaling Pathway Studies
- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Neurological diseases and metabolism
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Toxoplasma gondii Research Studies
- Management of metastatic bone disease
- Parasite Biology and Host Interactions
- Rabies epidemiology and control
- Veterinary Orthopedics and Neurology
- Liver Disease Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Pancreatic and Hepatic Oncology Research
- Parasitic Infections and Diagnostics
- Epigenetics and DNA Methylation
- Helminth infection and control
- Fungal Infections and Studies
- Bartonella species infections research
- Trypanosoma species research and implications
Texas A&M University
2016-2025
Royal North Shore Hospital
2019-2024
Mid Yorkshire Hospitals NHS Trust
2023
University of Bradford
2023
University of Tennessee at Knoxville
2020
Lincoln Memorial University
2019
College Station Medical Center
2018
Université de Montréal
2017
University of Wyoming
2017
University of Georgia
2011-2015
The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology board, comprising both veterinarian and physician neuropathologists, conducted comprehensive review of 193 cases canine glioma. immediate goal was to improve existing classification methods through creation histologic atlas features, thus yielding greater harmonization phenotypic characterization. long-term support future incorporation clinical outcomes genomic data into...
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared molecular profiles of canine with those human pediatric adult to characterize evolutionarily conserved mammalian mutational processes gliomagenesis. Employing whole-genome, exome, transcriptome, methylation sequencing 83 gliomas, we found alterations shared such as receptor tyrosine kinases, TP53 cell-cycle pathways, IDH1 R132. Canine showed high similarity...
Astrocytomas and oligodendrogliomas represent one third of histologically confirmed canine brain tumors. Our purpose was to describe the magnetic resonance (MR) imaging features intracranial astrocytomas examine for MR that differentiate these tumor types. Thirty animals with astrocytoma (14) or oligodendroglioma (16) were studied. All 12 located in cerebrum thalamus, remainder cerebellum caudal brainstem. Most (27/30) tumors associated both gray white matter. The signal characteristics...
ABSTRACT A severe, sometimes fatal respiratory disease has been observed in captive ball pythons ( Python regius ) since the late 1990s. In order to better understand this and its etiology, we collected case control samples performed pathological diagnostic analyses. Electron micrographs revealed filamentous virus-like particles lung epithelial cells of sick animals. Diagnostic testing for known pathogens did not identify an etiologic agent, so unbiased metagenomic sequencing was performed....
Automation and artificial intelligence (AI) is already possible for many radiation therapy planning treatment processes with the aim of improving workflows increasing efficiency in oncology departments. Currently, AI technology advancing at an exponential rate, as are its applications oncology. This commentary highlights way has begun to impact looks ahead potential future developments this space. Historically, therapist's (RT's) role evolved alongside adoption new technology. In Australia,...
Background: Although the histopathologic features of necrotizing meningoencephalitis (NME) have been described previously, little information is available concerning signalment, geographic distribution, seasonal onset, treatment, and survival affected dogs. Animals: Sixty Pugs with NME 14 contemporaneous control other intracranial diseases (non‐NME group). Methods: that were euthanized or died because disease prospectively obtained. All dogs had necropsy, histopathology, testing for various...
Background Granulomatous meningoencephalomyelitis ( GME ) and necrotizing meningoencephalitis NME are common inflammatory conditions of the central nervous system dogs. Infectious pathogens, particularly viruses, suspected to contribute etiopathogenesis . Hypothesis Broadly reactive PCR might aid in identification infectious agents Animals Sixty‐eight client‐owned dogs evaluated by necropsy at 1 university referral hospital. Methods A mixed prospective/retrospective case‐control study was...
Vector-transmitted microorganisms in the genera Ehrlichia, Anaplasma, Rickettsia, Bartonella, and Borrelia are commonly suspected dogs with meningoencephalomyelitis (MEM), but prevalence of these pathogens brain tissue cerebrospinal fluid (CSF) MEM is unknown.To determine if DNA from present CSF MEM, including those meningoencephalitis unknown etiology (MUE) histopathologically confirmed cases granulomatous (GME) necrotizing (NME).Hundred nine examined for neurological signs at 3 university...
Leishmaniasis is a zoonotic disease caused by intracellular Leishmania protozoa that are transmitted sandflies. The occurs in 3 forms: cutaneous, mucocutaneous, and visceral. Cutaneous leishmaniasis has been reported cats Europe South America 1 cat from Texas. mexicana endemic Texas to cause cutaneous lesions humans. This article describes the pathology of 8 biopsy cases feline presented Veterinary Medical Diagnostic Laboratory over 3.5-year period. median age was years; each with nodular,...
Previously we showed therapeutic efficacy of unprotected miR-124 in preclinical murine models glioblastoma, including heterogeneous genetically engineered by exploiting the immune system and thereby negating need for direct tumor delivery. Although these data were promising, to implement clinical trials, required a scalable formulation that afforded protection against circulatory RNases.We devised lipid nanoparticles encapsulate protect miRs from degradation provide enhanced delivery into...
Background Grading schemes for the assessment of hepatic fibrosis and necroinflammatory activity in humans previously have been applied to dogs with chronic hepatitis. Interobserver agreement is a desirable characteristic any histological scoring scheme. Hypothesis/Objectives To assess interobserver associated pathologists using published scheme compare scores assigned serial sections stained hematoxylin & eosin (H&E) picrosirius red. Animals Histological liver from 50 variable...
Necrotizing meningoencephalitis (NME) affects toy and small breed dogs causing progressive, often fatal, inflammation necrosis in the brain. Genetic risk loci for NME previously were identified pug dogs, particularly associated with dog leukocyte antigen (DLA) class II complex on chromosome 12, but have not been investigated other susceptible breeds. We sought to evaluate Maltese Chihuahua addition identify novel or shared genetic factors development. Genome-wide association testing of...
Cetacean morbillivirus (CeMV) is a major natural cause of morbidity and mortality in cetaceans worldwide results epidemic endemic fatalities. The pathogenesis CeMV has not been fully elucidated, questions remain regarding tissue tropism the mechanisms immunosuppression. We compared histopathologic viral immunohistochemical features molecularly confirmed CeMV-infected Guiana dolphins (Sotalia guianensis) from Southwestern Atlantic (Brazil) striped (Stenella coeruleoalba) bottlenose (Tursiops...
Cetacean morbillivirus (CeMV; Paramyxoviridae) is the most significant pathogen of cetaceans worldwide. The novel “multi-host” Guiana dolphin ( Sotalia guianensis; GD)-CeMV strain reported in South American waters and infects dolphins southern right whales Eubalaena australis). This study aimed to describe pathologic findings, GD-CeMV viral antigen distribution detection by RT-PCR (reverse transcriptase polymerase chain reaction), infectious comorbidities 29 that succumbed during an unusual...
Morphologic development of unidentified Sarcocystis sp. schizonts associated with encephalitis in a 9-wk-old gray fox (Urocyon cinereoargenteus) from Texas is described. were confined to lesions. They sparsely distributed and their staining affinity for hematoxylin eosin varied developmental stages; immature deeply stained compared mature schizonts. Most parasites extravascular the host cell was not identified those that intracellular. The parasite divided by endopolygeny, which nucleus...
Due to their unique population structure, purebred dogs have emerged as a key model for the study of complex genetic disorders. To evaluate utility newly available high-density canine whole-genome array with >170 000 single nucleotide polymorphisms (SNPs), genome-wide association was performed on small number case and control determine disease susceptibility loci in necrotizing meningoencephalitis (NME), disorder known non-Mendelian inheritance that shares clinical similarities atypical...
Background Canine necrotizing meningoencephalitis ( NME ) is a fatal, noninfectious inflammatory disease of unknown etiology. has been reported only in small number dog breeds, which led to the presumption that it breed‐restricted disorder. Hypothesis/Objectives Our objective was describe histopathologically confirmed breeds condition not previously and provide preliminary evidence affects wider spectrum than reported. Animals Four dogs with . Methods Archives from 3 institutions 1 author's...
Oligodendroglioma is one of the most common primary central nervous system neoplasms dogs. It often diagnosed in older, brachycephalic breeds, and although its typical clinical features neuroanatomic location have been well described, less presentations may hinder diagnosis. We describe 3 cases canine cerebral oligodendroglioma that clinically grossly present as intraventricular tumors. Histologic findings all were oligodendroglioma. Neoplastic cells uniformly immunoreactive for Olig2...
A 4‐year‐old, spayed‐female great Dane was referred for surgical treatment of a suspected meningioma, diagnosed on magnetic resonance imaging 10 days prior to presentation. The meningioma removed via image‐guided stereotactic craniotomy. Histopathological diagnosis severe, locally extensive, chronic meningoencephalitis with an intralesional nematode egg. egg morphologically consistent Eucoleus boehmi , and aberrant migration into the cranial cavity presumed cause this lesion. Three faecal...
The G M2 gangliosidoses are a group of lysosomal storage diseases caused by defects in the genes coding for enzyme hexosaminidase or activator protein. Four Jacob sheep from same farm were examined over 3-year period progressive neurologic disease. Two lambs 6-month-old intact males and 2 8-month-old females. Clinical findings included ataxia all 4 limbs, proprioceptive deficits, cortical blindness. At necropsy, nervous system appeared grossly normal. Histologically, most neurons within...