A5049889876- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary medicine and infectious diseases
- Bacterial Identification and Susceptibility Testing
- Veterinary Pharmacology and Anesthesia
- Pharmacological Effects and Assays
- Human-Animal Interaction Studies
- Veterinary Practice and Education Studies
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Behavior and Welfare Studies
- Diphtheria, Corynebacterium, and Tetanus
- Antibiotic Resistance in Bacteria
- Coccidia and coccidiosis research
- Aquaculture disease management and microbiota
- Inflammatory mediators and NSAID effects
- Veterinary Equine Medical Research
- Diet and metabolism studies
- Animal testing and alternatives
- Health Sciences Research and Education
- Helminth infection and control
- Meta-analysis and systematic reviews
- Reproductive Physiology in Livestock
- Animal health and immunology
- Innovations in Medical Education
Texas A&M University
2016-2025
Texas College
2013-2025
University of Georgia
2022
University of Tennessee at Knoxville
2021
Mitchell Institute
2020
American Association of Nurse Practitioners
2019
Qilu Hospital of Shandong University
2014
Baylor College of Medicine
2014
Angelo State University
2013
Michigan State University
2010
BackgroundThe immune therapeutic potential of microRNAs (miRNAs) in the context tumor-mediated suppression has not been previously described for monocyte-derived glioma-associated macrophages, which are largest infiltrating cell population glioblastomas and facilitate gliomagenesis.
Abstract The performance of antimicrobial susceptibility testing (AST) bacteria and the interpretation AST results for isolated from animals are complex tasks which must be performed using standard published methodology overseen by experts in clinical microbiology consultation with pharmacologists. Otherwise, has significant potential errors mistakes. In this review, we provide guidance on how to correctly perform interpret results. Particular emphasis is placed various approved or...
To determine current attitudes and practices related to pain analgesia in cattle among US veterinarians bovine practice identify factors associated with these practices.Web-based survey. Sample-3,019 members of the American Association Bovine Practitioners (AABP) e-mail addresses.Veterinarians were invited via participate a Web-based Respondents replied questions supplied personal, professional, demographic information. Descriptive statistical analysis was performed, associations various...
SUMMARY A scoping review was conducted to identify modifiable non-antimicrobial factors reduce the occurrence of antimicrobial resistance in cattle populations. Searches were developed retrieve peer-reviewed published studies animal, human and vitro microbial Citations retained when or interventions potentially associated with described. Studies described five bacterial genera, species types, 40 antimicrobials. Modifiable ranged widely type, depth evidence animal populations shallow....
Abstract Background Combatting antimicrobial resistance requires a One Health approach to stewardship including drug (AMD) use evaluation. Current veterinary AMD prescribing data are limited. Objectives To quantify companion animal in primary care and specialty practice across 3 academic hospitals with particular focus on third‐generation cephalosporins, fluoroquinolones, carbapenems. Animals Dogs cats presented from 2012 2017. Methods In this retrospective study, 2017 were extracted...
Abstract While there has been an abundance of studies on the important relationship between physical activity and age in both dogs humans, have primarily focused how a dog’s biological characteristics, such as their weight, affect age–activity relationship. To date, is little knowledge about this may be associated with contextual- owner-level characteristics. We leveraged large novel data set from Dog Aging Project (DAP) to investigate extent which certain dog owner namely size, age,...
Exposure to social environmental adversity is associated with health and survival across many species, including humans. However, little known about how these mortality effects vary the lifespan may be differentially impacted by various components of environment. Here, we leveraged a relatively new powerful model for human aging, companion dog, investigate which environment are dog associations lifespan. We drew on comprehensive survey data collected 21,410 dogs from Dog Aging Project...
Previously we showed therapeutic efficacy of unprotected miR-124 in preclinical murine models glioblastoma, including heterogeneous genetically engineered by exploiting the immune system and thereby negating need for direct tumor delivery. Although these data were promising, to implement clinical trials, required a scalable formulation that afforded protection against circulatory RNases.We devised lipid nanoparticles encapsulate protect miRs from degradation provide enhanced delivery into...
The Dog Aging Project (DAP) is a large-scale longitudinal study for studying aging in dogs. For some dogs the DAP, blood samples plasma isolation are collected by non-DAP personnel. However, sometimes inadequate, eg, insufficient volume assays. We aimed to examine three factors that may affect yield: resting time after sample collection, centrifugation time, and level of operator or technician training. designed experiments using convenience 5 Each experiment varied one held other two...
Cattle veterinarians have the responsibility of selecting, using, dispensing and prescribing drugs in a legal manner. The process for drug approval food animals U.S. is briefly reviewed, federal law allowing extralabel use detailed. Application regulations to exemplar case scenarios are presented illustration discussion.
ABSTRACT Building the skills and knowledge necessary to practice evidence‐based veterinary medicine (EBVM) should occur throughout curriculum. Operationalizing EBVM includes asking a clinical question in PICO format, searching biomedical literature for evidence, critically appraising applying evidence make recommendation. At Texas A&M University College of Veterinary Medicine & Biomedical Sciences, we have embedded skill‐reinforcing assignments into two rotations, Dermatology Food...
Abstract Objective —To compare the effectiveness of 3 treatment regimens for small ruminants with caseous lymphadenitis. Design —Randomized clinical trial. Animals —44 client-owned sheep and goats. Procedures —Aspirates were obtained from 48 lesions 44 enrolled animals submitted bacterial culture. randomly assigned to 1 groups. Treatment group A (n = 15 lesions) consisted opening, draining, flushing SC administration procaine penicillin G. B closed-system lavage intralesional tulathromycin....
Matrix metalloproteinase-9 is elevated within the acutely injured murine spinal cord and blockade of this early proteolytic activity with GM6001, a broad-spectrum matrix metalloproteinase inhibitor, results in improved recovery after injury. As likewise dogs naturally occurring injuries, we evaluated efficacy GM6001 solubilized dimethyl sulfoxide second species. Safety pharmacokinetic studies were conducted naïve dogs. After confirming safety, subsequent analyses demonstrated that 100 mg/kg...
Pain management in rabbits can be difficult because they are adept at hiding pain and stressed by handling restraint for injection. The use of opioid analgesics with prolonged durations activity could alleviate pain, but associated adverse effects including gastrointestinal ileus, inappetence, tissue reactions have been reported. In this study, we compared gross the site injection, food consumption, fecal production after single injections buprenorphine HCl (Bup; n = 7), sustained-release...
Abstract Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously relatively small cohorts of dogs using multiple different rating scales. This study aimed to use minimally modified CCD scale developed by previous researchers describe the prevalence more thoroughly large, nationwide cohort companion participating Dog Aging Project (DAP) (n = 15,019). Associations between various canine characteristics, predicted lifespan quartiles, and...
Clinical specimens from dogs, cats, and horses were examined for the presence of obligate anaerobic bacteria. Of 4,018 cultured, 368 yielded 606 isolates bacteria (248 50 308 horses). There 100 94 animals which only anaerobes isolated (25 8 61 The most common sites tested abdominal fluid (dogs cats) intestinal contents (horses). microorganism was Clostridium perfringens (75, 13, and101 isolates, respectively). MICs amoxicillin with clavulanate, ampicillin, chloramphenicol, metronidazole,...
Pneumonia caused by Pasteurella (Mannheimia) haemolytica was induced in weaned beef heifer calves, approximately 6 months of age. Calves were treated at 20 h after challenge with therapeutic doses danofloxacin or tilmicosin. Peripheral blood neutrophils collected 3, 24 and 48 treatment. The ex vivo effects on neutrophil function, apoptosis, hematological parameters examined, as the effect percentage lung consolidation. Neutrophil function assays included random migration under agarose,...
Abstract Objective —To compare apparent prevalence and patterns of antimicrobial resistance in Campylobacter spp feces collected from pigs reared with antimicrobial-free versus conventional production methods 8 states the Midwestern United States. Design —Cross-sectional study. Sample Population —95 swine farms that used (n = 35) or (60) methods. Procedures —Fecal samples 15 pigs/farm were collected. Biochemical multiplex-PCR analyses to identify spp. The minimal inhibitory concentrations...