A5070515648- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Global Public Health Policies and Epidemiology
- Frailty in Older Adults
- Health disparities and outcomes
- Human-Animal Interaction Studies
- Obesity, Physical Activity, Diet
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Air Quality and Health Impacts
- Noise Effects and Management
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Health, Environment, Cognitive Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Consumer Attitudes and Food Labeling
- Cardiac Health and Mental Health
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
University of Washington
2016-2025
Seattle University
2013-2025
Centers for Disease Control and Prevention
2010-2024
University of Newcastle Australia
2024
Seattle Public Schools
2023
SleepMed
2023
Seattle Children's Hospital
2023
Johns Hopkins University
2004-2022
East China University of Science and Technology
2020
Institute of Technology Sligo
2020
<b>Objective: </b> To compare associations of lean fish vs fatty (tuna or other fish) intake with dementia, Alzheimer disease (AD), and vascular dementia (VaD) in relation to <i>APOE</i> ε4 status the Cardiovascular Health Cognition Study (CHCS). <b>Methods: Fish was assessed by food frequency questionnaires. Incident AD, VaD were determined through a series cognitive tests, physician9s assessment, committee consensus. We used Cox proportional hazards regression calculate hazard ratios fried...
<h3>Objective:</h3> We sought to determine whether in the absence of clinical stroke, people with atrial fibrillation experience faster cognitive decline than without fibrillation. <h3>Methods:</h3> conducted a longitudinal analysis Cardiovascular Health Study, community-based study 5,888 men and women aged 65 years older, enrolled 1989/1990 or 1992/1993. Participants did not have history stroke at baseline. were censored when they experienced incident stroke. Incident was identified by...
Renal impairment is associated with an increased risk of carotid atherosclerosis and stroke, determinants cognitive dysfunction dementia. The purpose this study was to determine whether moderate renal incident dementia among community-dwelling older adults. Participants in the Cardiovascular Health Cognition Study without prevalent (n = 3349) were included analysis. Incident confirmed through neurologic testing. function at baseline estimated by inverse serum creatinine (1/SCr); defined as...
We evaluated self-perceived access to health care in a cohort of Medicare beneficiaries.We identified patterns use and barriers from self-administered questionnaires collected during the 1993-1994 annual examination Cardiovascular Health Study.The were completed by 4889 (91.1%) participants, with mean age 76.0 years. The most common seeing physician doctor's lack responsiveness patient concerns, medical bills, transportation, street safety. Low income, no supplemental insurance, older age,...
Recent evidence suggests that physical decline and slower gait may be associated with early signs of dementia, but more information on healthy older adults is needed.We determined associations between cognitive function, speed, self-reported measures function in 3035 mobile participants the Ginkgo Evaluation Memory Study evaluated 2000-2001. Gait speed was measured over a 15-foot course walking at both their usual rapid pace. Self-reported difficulties Activities Daily Living (ADLs) other...
Telomere length has emerged as a marker of exposure to oxidative stress and aging. Race/ethnic differences in telomere have been infrequently investigated. Leukocyte (LTL) was assessed 981 white, black Hispanic men women aged 45-84 years participating the Multi-Ethnic Study Atherosclerosis. Direct measurement questionnaire were used assess covariates. Linear regression estimate associations LTL with race/ethnicity age after adjustment for sex, income, education, smoking, physical activity,...
Epidemiologic and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce risk of Alzheimer disease (AD). We therefore investigated the association between use NSAIDs, aspirin, non-NSAID analgesic acetaminophen with incidence dementia AD.Participants in Cardiovascular Health Cognition Study included 3,229 individuals aged 65 or older, free at baseline, information on medication use. used Cox proportional hazards regression to estimate incident all-cause dementia,...
The aim of this study was to determine whether use diuretics, angiotensin-1 receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACE-I), calcium channel (CCB), or β-blockers (BB) associated with a reduced risk Alzheimer disease (AD) dementia in participants normal cognition mild cognitive impairment (MCI).Secondary longitudinal data analysis the Ginkgo Evaluation Memory Study older adults at least 75 years age (n = 1,928) MCI 320) over median 6.1-year period using Cox...
OBJECTIVES: To determine the relative effect of five chronic conditions on four representative universal health outcomes. DESIGN: Cross‐sectional. SETTING: Cardiovascular Health Study. PARTICIPANTS: Five thousand two hundred and ninety‐eight community‐living participants aged 65 older. MEASUREMENTS: Multiple regression Cox models were used to heart failure (HF), obstructive pulmonary disease (COPD), osteoarthritis, depression, cognitive impairment self‐rated health, 12 basic instrumental...
Organophosphate pesticide (OP) exposure to the U.S. population is dominated by dietary intake. The magnitude of from diet depends partly on personal decisions such as which foods eat and whether choose organic food. Most studies OP rely urinary biomarkers, are limited short half-lives often lack specificity parent compounds. A reliable means estimating long-term individual OPs needed assess potential relationship with adverse health effects.We assessed 14 among 4,466 participants in...
<h3>Importance</h3> Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major categories that largely define longevity in United States. However, it remains unclear whether LTL human life span. <h3>Objective</h3> To examine span contemporary humans. <h3>Design, Setting, Participants</h3> This cohort study included 3259 adults European ancestry from Cardiovascular Health Study (CHS), Framingham Heart (FHS), Women’s Initiative (WHI). was...
Research suggests that greenspace may confer neurocognitive benefits. This study examines whether residential is associated with risk of dementia among older adults.
Hearing and vision problems are individually associated with increased dementia risk, but the impact of having concurrent hearing deficits, ie, dual sensory impairment (DSI), on risk dementia, including its major subtypes Alzheimer disease (AD) vascular (VaD), is not well known.To evaluate whether DSI incident in older adults.This prospective cohort study from Cardiovascular Health Study (CHS) was conducted between 1992 1999, as many 8 years follow-up. The multicenter, population-based...
Abstract Background Although slow gait speed is an established risk factor for falls, few studies have evaluated change in as a predictor of falls or considered variability effects by cognitive status. Change may be more useful metric because its potential to identify decline function. In addition, older adults with mild impairment are at elevated falls. The purpose this research was quantify the association between 12-month and subsequent 6 months among without impairment. Methods Falls...
Background Falls contribute to impairments in activities of daily living (ADLs), resulting significant declines the quality life, safety, and functioning older adults. Understanding magnitude duration effect falls on ADLs, as well identifying characteristics adults more likely have post-fall ADL impairment is critical inform fall prevention intervention. The purpose this study 1) Quantify association between 2) Model trajectories pre- estimate long-term impact identify most impairment....
To compare dementia risks of elderly black and white subjects to determine whether differences in education cognitive test scores contribute the inconsistency reported between these groups.