A5088299044- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Polyomavirus and related diseases
- Urologic and reproductive health conditions
- Management of metastatic bone disease
- Full-Duplex Wireless Communications
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Antenna Design and Analysis
- Reading and Literacy Development
- Colorectal and Anal Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Neuroscience, Education and Cognitive Function
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Bacteriophages and microbial interactions
- Cancer survivorship and care
- Plant Virus Research Studies
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods in Clinical Trials
Royal North Shore Hospital
2016-2025
The University of Sydney
2016-2025
Northern Sydney Local Health District
2015-2025
University of Kentucky
2011-2023
St Vincent's Clinic
2023
St Vincent's Hospital Sydney
2019-2023
Australian and New Zealand Urogenital and Prostate Cancer Trials Group
2023
University of British Columbia
2023
Australian and New Zealand Intensive Care Society
2018-2022
Mater Health Services
2019-2021
In prostate cancer with biochemical failure after therapy, current imaging techniques have a low detection rate at the prostate-specific antigen (PSA) levels which targeted salvage therapy is effective. <sup>11</sup>C-choline and <sup>18</sup>F-fluoromethylcholine, though widely used, poor sensitivity PSA levels. <sup>68</sup>Ga-PSMA (Glu-NH-CO-NH-Lys-(Ahx)-[<sup>68</sup>Ga-<i>N,N</i>′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-<i>N,N</i>′-diacetic acid]) has shown promising...
<sup>68</sup>Ga-PSMA PET/CT scanning has been shown to be more sensitive than conventional imaging techniques in patients with prostate cancer. This prospective Australian multicenter study assessed whether affects management intent primary or recurrent <b>Methods:</b> Before undertaking PET imaging, referring medical specialists completed a questionnaire detailing relevant demographic and clinical data as well their proposed plan. A separate follow-up was after the scan results were...
Abstract Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tumor. polyoma virus (MCV) has been implicated in a majority of MCC tumors; however, viral-negative tumors have reported to be more prevalent some geographic regions subject high sun exposure. While the impact MCV and viral T-antigens on development extensively investigated, little known about etiology tumors. We performed targeted capture massively parallel DNA sequencing 619 cancer genes compare gene...
To examine the detection rates of (68) Ga-PSMA-positron emission tomography (PET)/computed (CT) in patients with biochemical recurrence (BCR) after radical prostatectomy (RP), and also impact on their management.A total 300 consecutive prostate cancer (PCa) who underwent Ga-PSMA-PET/CT between February July 2015 were prospectively included Prostate Cancer Imaging (ProCan-I) database. For present analysis, we BCR (prostate-specific antigen [PSA] level ≥0.05 <1.0 ng/mL) RP, being considered...
Prostate-specific membrane antigen (PSMA) may be targeted for both diagnostic and therapeutic purposes in the management of prostate cancer (PCa). In preclinical models, androgen blockade (AB) increases expression PSMA hormone-sensitive castrate-resistant xenotypes. The aim this study was to evaluate effect AB treatment on <sup>68</sup>Ga-PSMA-11 PET imaging hormone-naive (luteinizing hormone-releasing hormone [LHRH] ± bicalutamide) men (enzalutamide or abiraterone) with metastatic PCa....
We assessed the feasibility of a watchful waiting protocol with selective delayed intervention using clinical, prostate specific antigen (PSA) or histological progression as treatment indications for clinically localized cancer.In this prospective, single arm cohort study patients favorable clinical parameters (stage T1b to T2b N0M0, Gleason score 7 less and PSA 15 ng./ml. less) are conservatively treated waiting. When patient meets disease criteria, arbitrarily defined by 3 rate increase,...
<sup>68</sup>Ga-PSMA (prostate-specific membrane antigen) PET/CT is increasingly used in men with prostate-specific antigen (PSA) failure after radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA-informed SRT improving outcomes context biochemical RP. <b>Methods:</b> We analyzed rising PSA RP readings between 0.05 and 1.0 ng/mL, considered eligible for at time PSMA. For each patient, clinical pathologic...
Several studies have suggested that desmoplastic neurotropic melanoma (DNM) is associated with higher local recurrence rates than other types of melanoma. The authors investigated the for patients DNM after surgery alone or followed by radiotherapy (RT).One hundred twenty-eight were treated at Sydney Melanoma Unit and Cancer Center from 1996 to 2007. All underwent excision, 27 also received RT. For both groups, clinical pathologic features, treatment details, data analyzed.The median age...
<sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT is increasingly used in men with biochemical recurrence (BCR) after radical prostatectomy (RP), but its longer-term prognostic or predictive potential these unknown. The aim of this study was to evaluate the value PSMA PET for a 3-y freedom from progression (FFP) BCR RP undergoing salvage radiotherapy (sRT). <b>Methods:</b> This prospective multicenter enrolled 260 between 2015 and 2017. Eligible patients were referred...
Objective To evaluate the ability of prostate‐specific membrane antigen ( PSMA )‐positron‐emission tomography PET )/computed CT ) to detect intermediate‐grade intra‐prostatic prostate cancer PC a), and determine if ‐ improves diagnostic accuracy multiparametric magnetic resonance imaging (mp MRI ). Patients Methods A total 56 consecutive patients with International Society Urological Pathology ISUP grade 2–3 a after radical prostatectomy, who underwent both mp (hereafter preoperatively, were...
The brain is a common site of metastasis for patients with high-risk melanoma. Although surgery or stereotactic radiosurgery are highly effective local treatments small number metastases, there high risk developing additional metastases. role adjuvant whole-brain radiotherapy (WBRT) in reducing new metastases controversial, lack high-level evidence specifically melanoma.In this randomized phase III trial, who had treatment one to three melanoma were randomly assigned WBRT observation....
Background Fear of cancer recurrence (FCR) is a common and severe problem amongst survivors, but mechanisms to explain its development maintenance are still lacking. The self-regulatory executive function (S-REF) model suggests that metacognitions attentional bias cancer-related words may high FCR. Thus, this study aimed explore relationships between FCR, in mixed group survivors. Method Sixty-three early-stage breast or prostate diagnosed within 6 months 5 years prior participation who had...
Abstract Objective This cross‐sectional study aimed to identify the prevalence and correlates of supportive care needs in testicular cancer (TC) survivors. Methods Men who had completed active anti‐cancer treatment for TC between 6 months 5 years previously showing no evidence recurrence were recruited from 14 Australian centers (September 2009–February 2011). Participants a self‐report questionnaire measuring sociodemographics, disease, information, (CaSUN), psychological distress (DASS21)...