A5012824041- Advanced Breast Cancer Therapies
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Aquaculture disease management and microbiota
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Fish Biology and Ecology Studies
- Aquaculture Nutrition and Growth
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Water Quality and Pollution Assessment
- Peptidase Inhibition and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Heavy metals in environment
- Chronic Lymphocytic Leukemia Research
- Heavy Metal Exposure and Toxicity
- Virus-based gene therapy research
- Head and Neck Cancer Studies
- Vibrio bacteria research studies
- Identification and Quantification in Food
- RNA Interference and Gene Delivery
- Escherichia coli research studies
Ehime University
2023-2025
University of Dhaka
2015-2025
The University of Texas MD Anderson Cancer Center
2015-2025
American InterContinental University
2024
American University
2024
National Institute of Cancer Research and Hospital
2022-2024
University of Rajshahi
2024
Eli Lilly (United States)
2006-2023
Northern University Bangladesh
2023
Daffodil International University
2023
MicroRNAs are an extensive family of ∼22-nucleotide-long noncoding RNAs expressed in a wide range eukaryotes, including humans, and they important development disease. We found that microRNA Mir-17-5p has complementarity to the mRNA AIB1 (named for “amplified breast cancer 1”). Cell culture experiments showed expression was downregulated by Mir-17-5p, primarily through translational inhibition. Expression low cell lines. also downregulation resulted decreased estrogen receptor-mediated, as...
Purpose The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and thoracic radiation therapy (TRT) followed by consolidation pemetrexed, versus etoposide-cisplatin TRT nonpemetrexed doublet therapy. Patients Methods with stage IIIA/B unresectable nonsquamous non–small-cell lung cancer randomly received (1:1) pemetrexed 500 mg/m 2 cisplatin 75 intravenously every 3 weeks for three cycles plus (60 to 66 Gy) four (arm A), or standard etoposide 50...
Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and immune system. We sought to determine whether exosomes from glioblastoma (GBM)-derived stem cells (GSCs) induce immunosuppression. report that GSC-derived (GDEs) have predilection for monocytes, precursor macrophages. The GDEs traverse monocyte cytoplasm, cause reorganization actin cytoskeleton, skew monocytes toward suppresive M2 phenotype, programmed...
MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs most effective against glioblastomas and how these should be delivered major unanswered problems. To identify potent antiglioma miRs, we selected 8 based on a literature search screened them panel of glioma stem cell (GSC) lines, representing all the glioblastoma subtypes defined by The Cancer Genome Atlas. address delivery, tested hypothesis that ex vivo cultured bone marrow–derived mesenchymal cells...
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes increase the proliferation and clonogenicity tumor-initiating glioma stem-like (GSC). This event leads to significantly greater tumor burden decreased host survival compared with untreated GSCs orthotopic xenografts. Analysis exosomal content miR-1587 as...
Abstract Although mesenchymal stem cells (MSCs) have been implicated as stromal components of several cancers, their ultimate contribution to tumorigenesis and potential drive cancer cells, particularly in the unique microenvironment human brain tumors, remain largely undefined. Consequently, using established criteria, we isolated glioma-associated-human MSCs (GA-hMSCs) from fresh glioma surgical specimens for first time. We show that these GA-hMSCs are nontumorigenic phenotypically similar...
neoMONARCH assessed the biological effects of abemaciclib in combination with anastrozole neoadjuvant setting.Postmenopausal women stage I-IIIB HR+/HER2- breast cancer were randomized to a 2-week lead-in abemaciclib, anastrozole, or plus followed by 14 weeks combination. The primary objective evaluated change Ki67 from baseline 2 treatment. Additional objectives included clinical, radiologic, and pathologic responses, safety, as well gene expression changes related cell proliferation immune...
A follow-up in 1262 women was conducted after the discontinuation of teriparatide. The hazard ratio for combined teriparatide group (20 and 40 microg) 50-month period baseline 0.57 (p = 0.002), suggesting a sustained effect reducing risk nonvertebral fragility fracture.Treatment with [rhPTH(1-34)] 20 microg once-daily subcutaneous dosing significantly reduced fractures over median exposure 19 months.All participants Fracture Prevention Trial were invited to participate study. Prior treatment...
The product of the Wilms' tumor gene, WT1, is essential for male sex determination and differentiation in mammals. In addition to causing tumor, mutations WT1 often cause two distinct but overlapping urogenital defects men, Denys-Drash syndrome Frasier syndrome. this study we investigated regulation gene SRY by WT1. Our results showed that up-regulates through proximal early growth response gene-1-like DNA-binding sequences core promoter. Mutant proteins patients were unable activate These...
Rivers, often the primary recipients of untreated domestic and industrial effluents, have increasingly become reservoirs potent toxins, particularly heavy metals, raising serious concerns for health both human aquatic life. This study investigates ecological risks associated with metal accumulation in sediments fish from Padma River, a major river system Bangladesh. Using Atomic Absorption Spectrometry (AA-7000 series), we analysed concentrations cadmium (Cd), chromium (Cr), copper (Cu),...
Copper is an essential metal nutrient, yet copper overload toxic. Here, we report that human transporter (hCtr) 1 plays important role in the maintenance of homeostasis by demonstrating expression hCtr1 mRNA was up-regulated under copper-depleted conditions and down-regulated copper-replete conditions. Overexpression full-length transfection with a recombinant <i>hCtr1</i> cDNA clone reduced endogenous levels, whereas overexpression N terminus-deleted did not change suggesting increased...
Abstract Although studies have suggested that bone marrow human mesenchymal stem cells (BM-hMSC) may be used as delivery vehicles for cancer therapy, it remains unclear whether BM-hMSCs are capable of targeting cells, including glioma (GSC), which the tumor-initiating responsible treatment failures. Using standard models, we identify TGF-β a tumor factor attracts via receptors (TGFβR) on BM-hMSCs. and rat GSCs, then show first time intravascularly administered home to GSC-xenografts express...
Human mesenchymal stem cells (hMSCs) have been shown to reside as stromal in human gliomas glioma-associated hMSCs (GA-hMSCs), but their biological role remains unclear. Because recent evidence indicates that GA-hMSCs drive tumor cell proliferation and stemness, we hypothesized a higher percentage of tumors predicts poor patient prognosis.We determined the coexpressing GA-hMSC markers CD105+/CD73+/CD90+ from patients with newly diagnosed high-grade glioma analyzed association between this...
Although originally isolated from the bone marrow, mesenchymal stem cells (MSCs) have recently been detected in other tissues. However, little is known about MSCs brain.To determine extent to which with features of exist normal brain tissue and location these brain.Single-cell suspensions mouse brains were cultured according same methods used for culturing marrow-derived (BM-MSCs). These brain-derived analyzed by fluorescence-activated cell sorting surface markers associated BM-MSCs (stem...
Previous studies have demonstrated that treating cultured cells with cisplatin (CDDP) up-regulated the expression of glutathione (GSH) and its de novo rate-limiting enzyme glutamate-cysteine ligase (GCL), which consists a catalytic (GCLC) modifier (GCLM) subunit. It has also been shown many CDDP-resistant cell lines exhibit high levels GCLC/GCLM GSH. Because GSH system is major intracellular regulator redox conditions serve as an important detoxification cytoprotector, these results taken...
Abstract Background Glioblastoma (GBM) has poor prognosis due to ineffective agents and delivery methods. MicroRNAs (miRs) have been explored as novel therapeutics for GBM, but the optimal miRs ideal strategy remain unresolved. In this study, we sought identify most effective pan-subtype anti-GBM develop an improved system these miRs. Methods We conducted unbiased screen of over 600 against 7 glioma stem cell (GSC) lines representing all GBM subtypes a set pan-subtype-specific then used...
This paper compares several methods for estimating the parameters of two-parameter Weibull distribution with complete, multiply time censored, and type II censored samples. An extensive simulation study performance these estimators.
OBJECTIVE Mesenchymal stem cells (MSCs) have been shown to localize gliomas after intravascular delivery. Because these home areas of tissue injury, the authors hypothesized that administration ionizing radiation (IR) tumor would enhance tropism MSCs gliomas. Additionally, they sought identify which radiation-induced factors might attract MSCs. METHODS To assess effect IR on MSC migration in vitro, transwell assays using conditioned medium (CM) from an irradiated commercially available...
<h3>Importance</h3> The appropriate use of surgery or radiotherapy-based approaches for organ preservation has been the subject much debate. Unfortunately, there a lack improvement in overall survival patients with laryngeal carcinoma last 30 years. <h3>Objective</h3> To assess rates and laryngectomy-free receiving cetuximab radiotherapy (CRT) alone. <h3>Design, Setting, Participants</h3> Patients were enrolled multicenter, open-label, stratified, randomized, phase 3 study from April 1,...