A5085711321- Virus-based gene therapy research
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- interferon and immune responses
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Structural Anomalies and Repair
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Mechanical Circulatory Support Devices
- Genomics and Phylogenetic Studies
- Caveolin-1 and cellular processes
- Cancer Treatment and Pharmacology
- Extracellular vesicles in disease
- Chemical Reactions and Isotopes
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- RNA Interference and Gene Delivery
- Gene expression and cancer classification
The University of Texas MD Anderson Cancer Center
2014-2025
Columbia University
2021-2024
Columbia University Irving Medical Center
2023-2024
Texas Health Dallas
2023-2024
Massachusetts General Hospital
2024
University Hospital Regensburg
2024
Roivant Sciences (United States)
2020-2022
The University of Texas Health Science Center at Houston
2015
University of Tübingen
1995-2015
Heidelberg University
1995
Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe TumorFusions, data portal that catalogues 20 731 gene fusions detected 9966 well characterized samples 648 normal specimens from The Cancer Genome Atlas (TCGA). spans 33 types TCGA. Fusion transcripts were identified via uniform pipeline, including filtering against list 3838 transcript panel non-neoplastic samples. Fusions mapped to somatic DNA...
MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs most effective against glioblastomas and how these should be delivered major unanswered problems. To identify potent antiglioma miRs, we selected 8 based on a literature search screened them panel of glioma stem cell (GSC) lines, representing all the glioblastoma subtypes defined by The Cancer Genome Atlas. address delivery, tested hypothesis that ex vivo cultured bone marrow–derived mesenchymal cells...
Glioblastoma (GBM) is the most common and aggressive form of brain cancer. Our previous studies demonstrated that combined inhibition HDAC KDM1A increases apoptotic cell death in vitro. However, whether this combination also glioma stem (GSC) population or has an effect vivo yet to be determined. Therefore, we evaluated translational potential on patient-derived GSCs xenograft GBM mouse models. We investigated changes transcriptional programing induced by effort understand molecular...
GM-CSF (granulocyte-macrophage colony-stimulating factor) has emerged as a promising target against the hyperactive host immune response associated with coronavirus disease (COVID-19).
Introduction Right heart failure (RHF) is a well-known complication after left ventricular assist device (LVAD) implantation and portends increased morbidity mortality. Understanding the mechanisms predictors of RHF in this clinical setting may offer ideas for early identification aggressive management to minimize poor outcomes. A variety medical therapies mechanical circulatory support options are currently available post-LVAD RHF.
Abstract Introduction A previous phase 2b study supported the use of 5‐HT6 receptor antagonist intepirdine as adjunctive therapy to donepezil for Alzheimer's disease (AD) dementia. 3 study, MINDSET, was performed test this hypothesis. Methods MINDSET a global, double‐blind, randomized, placebo‐controlled trial in 1315 mild‐to‐moderate AD dementia patients on stable donepezil. Patients received 35 mg/day or placebo 24 weeks. The co‐primary endpoints were change from baseline week Disease...
Abstract BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults and associated with abysmal patient outcomes. While it well-known that glutamatergic neurons can form functional synapses GBM cells to enhance growth, less known about effects of activity other neuronal types on biology. Here, we examined effect acetylcholine growth belonging different molecular subtypes. We also explored ways modulate produced by cholinergic mouse basal forebrain further study...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells, including gliomas, and is currently anticancer clinical trials. However, the full-length tagged forms of TRAIL, unlike untagged (soluble TRAIL (sTRAIL)), exhibits toxicity against normal cells. Here, we report generation testing an adenovirus (AdsTRAIL) that expresses sTRAIL intracranial xenograft model a human glioma organotypic slice culture model. AdsTRAIL efficiently...
Abstract DNX-2401 is a replication competent oncolytic adenovirus that has shown potent antitumor effect in preclinical glioma models and safe profile when administer as single agent patients. Previously, our group showed combination of with temozolomide significantly increased the survival mice bearing gliomas. Even though virotherapy becoming real therapeutic option still precise mechanism action, interplay tumor microenvironment biomarkers predict response remain elusive. The main...
Abstract Introduction A phase 2b clinical trial, HEADWAY‐DLB, was performed to assess treatment with intepirdine, a serotonin receptor antagonist, in patients dementia Lewy bodies (DLB). Methods HEADWAY‐DLB multinational, double‐blind, randomized, placebo‐controlled study. Two hundred sixty‐nine DLB were randomized receive placebo, 70 mg/day or 35 intepirdine over 24 weeks. The primary endpoint change from baseline week on the Unified Parkinson's Disease Rating Scale–Part III (UPDRS‐III)....
Zellschwellung wird durch Freisetzung von Ionen (K+-Kanal und/oder Anionen-Kanal-Aktivierung, KCl-Kotransport, gleichzeitige Aktivierung K+/H+-Austauscher und Cl–/HCO3 –-Austauscher) kompensiert, während Zellschrumpfung regulatorische Ionenaufnahme ausgeglichen (Aktivierung Na+, K+, 2Cl–-Kotransport, Na+/H+-Austausch bei gleichzeitigem –-Austausch Na+-Kanälen). Zusätzlich werden organische Osmolyte akkumuliert (z. B.: Myoinositol, Betain, Phosphorylcholin, Taurin). Das Zellvolumen kann den...
Valve-in-valve (VIV) transcatheter aortic valve implantation (TAVI) is a less invasive therapeutic option compared with redo surgical replacement for high-risk patients. Relative to procedures within stented valves, VIV-TAVI stentless valves associated higher complication rate due challenging underlying anatomy and absence of fluoroscopic landmarks.We share single-center experience in discussing our procedural insights outcomes.Our institutional database was queried, 25 patients who had...
Abstract Introduction/Purpose NT-proBNP is a widely used diagnostic marker in the emergency department (ED). The main objective of current study was to determine association patients with chest pain presenting sinus rhythm (SR) compared atrial fibrillation (AFib). Hereby, focus evaluation serum head-to-head urinary NT-proBNP. Methods In this study, as well blood concentrations were measured total 601 patients, who presented acute ED (mean age = 61.1 y, SD 16.9 y). initial ECG 68 suffered...
<h3>Background</h3> Previous trials testing oncolytic adenovirus Delta-24-RGD in malignant gliomas has shown encouraging results. Since viruses can stimulate immune reactions against both virus and tumor, immunodominance of viral antigens may prevent the preferred generation tumor-specific clones. In this work, we tested extent to which nanoparticle-induced tolerance shift focus system tumor improves therapeutic outcome. <h3>Methods</h3> Genomic DNA from surgical samples 9 glioma patients...
<h3>Background</h3> Natural killer (NK) cells are crucial for eliminating tumor and virally-infected by integrating signals from activating inhibitory receptors. While NK-cell therapy has shown success in treating leukemias lymphomas, its effectiveness against solid tumors remains limited due to tumor-mediated suppression. Oncolytic viruses, which selectively target kill while enhancing antitumor immunity, offer a promising approach overcoming this Our study aims elucidate the mechanisms...
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myeloid cell growth and pro-inflammatory cytokine, may drive the overactive host immune response in COVID-19. We conducted clinical trial assessing anti-GM-CSF monoclonal antibody gimsilumab for hyperinflammatory COVID-19 pneumonia (BREATHE). Here, we report pre-specified subgroup analysis demonstrating signal of benefit patients invasively ventilated at baseline. Methods: BREATHE (NCT04351243) was double-blind,...