A5037079426- Cancer-related cognitive impairment studies
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- RNA Research and Splicing
- Digestive system and related health
- Pluripotent Stem Cells Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Chemical Reactions and Isotopes
- 3D Printing in Biomedical Research
- Chemokine receptors and signaling
- Protein Structure and Dynamics
- Autoimmune and Inflammatory Disorders
- Machine Learning in Bioinformatics
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- SARS-CoV-2 and COVID-19 Research
The University of Texas MD Anderson Cancer Center
2020-2025
The University of Texas Southwestern Medical Center
2021
University of Miami
2021
University of California, Irvine
2021
National Institutes of Health
2021
University of Houston
2018-2020
Genomics Research Center, Academia Sinica
2013-2014
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There no FDA-approved treatment for these neurotoxicities. We investigated the capacity of a highly selective A3 adenosine receptor (AR) subtype (A3AR) agonist, MRS5980, prevent reverse cisplatin-induced MRS5980 prevented impairment (decreased executive function impaired spatial working memory), neuropathic pain (mechanical...
Cognitive deficits (chemobrain) and peripheral neuropathy occur in ∼75% of patients treated for cancer with chemotherapy persist long-term >30% survivors. Without preventive or curative interventions increasing survivorship rates, the population debilitated by these neurotoxicities is rising. Platinum-based chemotherapeutics, including cisplatin, induce neuronal mitochondrial defects leading to chemobrain neuropathic pain. This study investigates capacity nasally administered mesenchymal...
Abstract Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality life an increasing number survivors. The underlying mechanisms are not fully understood there is no effective treatment. We show here cisplatin mice only caused dysfunction but also impaired function. These functional associated with reduced myelin density complexity in cingulate cortex. At ultrastructural level,...
Interferon (IFN) signaling contributes to stemness, cell proliferation, death, and cytokine in cancer immune cells; however, the role of IFN glioblastoma (GBM) GBM stem-like cells (GSCs) is unclear. Here, we investigated cancer-cell-intrinsic tumorigenesis GBM. We report here that GSCs tumors exhibited differential cell-intrinsic type I II signaling, high IFN/STAT1 was associated with mesenchymal phenotype poor survival outcomes. In addition, chronic inhibition decreased proliferation...
Breast cancer is the most common female malignancy in both developed and developing world.Doxorubicin one of commonly used chemotherapies for breast cancer.Unfortunately, up to 60% survivors report long-term chemotherapy-induced cognitive dysfunction (CICD) characterized by deficits working memory, processing speed executive function.Currently, no therapeutic standard treating CICD exists.Here, we hypothesized that treatment with a blood-brain barrier permeable histone deacetylase 6 (HDAC6)...
Abstract Complications associated with Type 1 and 2 diabetes, such as diabetic peripheral neuropathy foot ulcers, are a growing health-care concern. In addition, this concern increases patients age due to their increased susceptibility complications. To address problem, it is important understand fluctuations in physiology which lead pathological changes the metabolic disturbances of diabetes. Our study explores dysregulation immune cell populations hindpaws healthy mice at 12 21 weeks using...
Abstract Coronavirus disease‐2019 (COVID‐19) is a global pandemic and caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which has resulted in millions of deaths worldwide. Reports denote SARS‐CoV‐2 uses angiotensin‐converting enzyme (ACE2), transmembrane serine protease (TMPRSS2) as its primary entry point into the host cell. However, understanding biology behind this viral replication, disease mechanism drug discovery efforts are limited due to lack suitable...
Abstract BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults and associated with abysmal patient outcomes. While it well-known that glutamatergic neurons can form functional synapses GBM cells to enhance growth, less known about effects of activity other neuronal types on biology. Here, we examined effect acetylcholine growth belonging different molecular subtypes. We also explored ways modulate produced by cholinergic mouse basal forebrain further study...
Reports of neurological sequelae related to colon cancer are largely restricted rare instances paraneoplastic syndromes, due autoimmune reactions. Systemic inflammation associated with tumor development influences sensory neuron function in other disease models, though the extent which this occurs colorectal is unknown. We induced orthotopic via injection two cell lines (MC38 and CT26) different mouse strains (C57BL/6 Balb/c, respectively). Behavioral tests pain sensitivity activity did not...
Neurotoxic side effects of chemotherapy include deficits in attention, memory, and executive functioning. Currently, there are no FDA-approved therapies. In mice, cisplatin causes long-term cognitive deficits, white matter damage, mitochondrial dysfunction, loss synaptic integrity. We hypothesized that MSC-derived small extracellular vesicles (sEVs) could restore cisplatin-induced impairments brain damage. Animals were injected with intraperitoneally treated sEVs intranasally 48 96 h after...
Abstract Background Epidermal growth factor receptor (EGFR) amplification is found in nearly 40%–50% of glioblastoma cases. Several EGFR inhibitors have been tested but failed to demonstrate long-term therapeutic benefit, presumably because acquired resistance. Targeting downstream signaling with mitogen-activated protein kinase 1 and 2 (MEK1/2) would be a more effective approach treatment. We the potential MEK1/2 using 3D cultures glioma stem-like cells (GSCs) mouse models glioblastoma....
Background and Purpose: Lack of suitable experimental models hinders SARS-CoV-2 research. Reports denote uses ACE2, TMPRSS-2 as its primary receptors. However, clinical symptoms were also related to organs with poor or no expressions Hence, using single-cell RNA sequencing data human organoids, we analyzed expression levels receptors array for their involvement in pathogenesis. Experimental Approach: From the gene omnibus (GEO) express database, normalized cell counts intestine coventional,...
Abstract BACKGROUND Because of major advancements in cancer treatment especially chemotherapy, 85% children with are predicted to survive for 5 years or more. However, chemotherapy can cause long-term health problems when childhood survivors enter adulthood (known as late effects). The neurocognitive features these effects (chemobrain) include trouble concentrating, memorizing, and decreased processing speed, results lower IQ academic achievement, poor hand-eye coordination, slower...
Abstract INTRODUCTION Glioblastoma (GBM) are the most common primary brain tumor in adults associated with a dismal patient outcome. While it is well-known that glutamatergic neurons can form functional synapses glioblastoma cells to enhance growth, lesser known about effects of activity other neuronal types on biology, especially among different molecular subtypes. Here, we examined various neurotransmitters growth characterized as classical, proneural and mesenchymal METHODS...
Abstract Because of major advancements in cancer treatment especially chemotherapy, 85% children with are predicted to survive for 5 years or more. However, chemotherapy can cause long-term health problems when childhood survivors enter adulthood (known as late effects). The neurocognitive features these effects (chemobrain) include trouble concentrating, memorizing, and decreased processing speed, results lower IQ academic achievement, poor hand-eye coordination, slower development over...
Background: Right ventricular failure (RVF) impacts the prognosis of pulmonary arterial hypertension (PAH). Alternative polyadenylation (APA) generates transcript diversity and is implicated in diseases, including left heart failure. However, understanding genome-wide maps RVF patients with PAH limited, no studies investigating RVF-specific APA events. Objective: This study mapped 3' untranslated regions (3'UTRs) to explore dynamics development, comparing healthy donors from PAH. Methods...
A robust and reliable culture system of adult stem cells is essential for applying the cutting-edge technologies drug screening, gene editing, genomics to cell research necessary breakthroughs in this field. In addition, personalized regenerative medicine based on autologous transplantation requires our ability clone expand numbers these vitro. comparison 3D "organoid" that shows limited propagate as majority are differentiated or transit amplifying cells, ground-state a novel technology...