A5067623584- Pain Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Anorectal Disease Treatments and Outcomes
- Inflammasome and immune disorders
- Congenital gastrointestinal and neural anomalies
- Autoimmune Neurological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Hereditary Neurological Disorders
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Receptor Mechanisms and Effects
- Migraine and Headache Studies
- Pelvic floor disorders treatments
- Photoreceptor and optogenetics research
- Inflammatory mediators and NSAID effects
- Blood groups and transfusion
The University of Texas Health Science Center at Houston
2024
The University of Texas at Dallas
2020-2023
The University of Texas Southwestern Medical Center
2021
Single-cell gene expression analysis predicts pain signaling pathways between sensory neurons and peripheral cell types.
Abstract Background Automated infrared pupillometry (AIP) and the Neurological Pupil index (NPi) provide an objective means of assessing trending pupillary light reflex (PLR) across a broad spectrum neurological diseases. NPi quantifies PLR ranges from 0 to 5; in healthy individuals, both eyes is expected be ≥ 3.0 symmetric. AIP values demonstrate emerging value as prognostic tool with predictive properties that could allow practitioners anticipate deterioration recovery. The presence...
Abstract Cells communicate with each other through ligand and receptor interactions. In the case of peripheral nervous system, these ligand-receptor interactions shape sensory experience. disease states, such as chronic pain, can change excitability target neurons augmenting nociceptive input to CNS. While importance cell neuron are widely acknowledged, they have not been thoroughly characterized. We sought address this by cataloging how types interact in dorsal root ganglion (DRG) using RNA...
The SARS-CoV-2 virus infects cells of the airway and lungs in humans causing disease COVID-19. This is characterized by cough, shortness breath, severe cases causes pneumonia acute respiratory distress syndrome (ARDS) which can be fatal. Bronchial alveolar lavage fluid (BALF) plasma from mild COVID-19 have been profiled using protein measurements bulk single cell RNA sequencing. Onset ARDS rapid COVID-19, suggesting a potential neuronal involvement pathology mortality. We sought to quantify...
We present the perianal exam and lumbosacral sensory evaluation of children who have undergone fetoscopic repair an open neural tube defect.
Persistent hyperactivity of nociceptors is known to contribute significantly long-lasting sensitization and ongoing pain in many clinical conditions. It often assumed that nociceptor mainly driven by continuing stimulation from inflammatory mediators. We have tested an additional possibility: persistent increases excitability promoting can be induced a prototypical cellular signaling pathway long induce late-phase long-term potentiation (LTP) synapses brain regions involved memory formation....
Cells communicate with each other through ligand and receptor interactions. In the case of peripheral nervous system, these ligand-receptor interactions shape sensory experience. disease states, such as chronic pain, can change excitability target neurons augmenting nociceptive input to CNS. While importance cell neuron are widely acknowledged, they have not been thoroughly characterized. We sought address this by cataloging how types interact in dorsal root ganglion (DRG) using RNA...
Introduction. The pupillary light reflex (PLR) is an integral aspect of the neurologic exam. With enhancement automated infrared pupillometry (AIP), Neurological Pupil index (NPi) being increasingly used when performing a neurological examination. NPi difference (the absolute between paired readings from left and right eye) relatively unexplored variable in AIP assessment.Aim. This study evaluates association Glasgow Coma Scale (GCS) scores differences eyes, normal, patients enrolled...