A5008259781- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Grief, Bereavement, and Mental Health
- Head and Neck Surgical Oncology
- Fetal and Pediatric Neurological Disorders
- Urological Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Tissue Engineering and Regenerative Medicine
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital gastrointestinal and neural anomalies
- Hernia repair and management
- Craniofacial Disorders and Treatments
- Anatomy and Medical Technology
- Personality Traits and Psychology
- Trauma and Emergency Care Studies
- Maternal and Perinatal Health Interventions
- Cleft Lip and Palate Research
- Facial Trauma and Fracture Management
- Personality Disorders and Psychopathology
- Injury Epidemiology and Prevention
- Bacterial Infections and Vaccines
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
The University of Texas Health Science Center at Houston
2015-2024
Memorial Hermann
2015-2024
Neurological Surgery
2023
Center for Clinical Research (United States)
2021
American Society of Plastic Surgeons
2021
Novartis (Germany)
2021
The University of Texas MD Anderson Cancer Center
2021
University of Padua
2021
Ochsner Medical Center
2020
Ochsner Health System
2019
Background Blood samples collected in rural and remote areas of Australasia are often exposed to a range environmental conditions prior analysis laboratory. The aim this study was determine analyte stability venous blood specimens serum gel tubes storage temperatures times centrifugation. Methods Thirty healthy adult volunteers were enrolled the study. into 11 separator tubes. All allowed clot at room temperature for 30 min. Two centrifuged analysed as controls. Nine stored 15, 25 or 35°C 4,...
Abstract BACKGROUND: The repressor element‐1 silencing transcription factor (REST) is a of neuronal genes. Its expression associated with poor differentiation in many neuroblastoma patient samples and cell lines. Because retinoic acid promotes differentiation, the authors postulated that it involves modulation REST expression. METHODS: an S‐phase kinase‐associated protein 1/cullin 1/F‐box (SCF) complex contains F‐box β‐transducin repeat‐containing (β‐TRCP) (SCF β‐TRCP ) tumor lines was...
OBJECTIVE The objective of this study was to assess the incidence, diagnosis, and treatment pediatric blunt cerebrovascular injury (BCVI) at a busy Level 1 trauma center develop tool for accurately predicting BCVI need diagnostic testing. METHODS This is retrospective cohort prospectively collected database patients who had sustained (patient age range 0-15 years) were treated between 2005 2015. Digital subtraction angiography, MR or CT angiography used confirm BCVI. Recently, Utah score has...
To identify a patch system to repair surgically created spina bifida in sheep model for its efficacy healing the skin defect, protecting underlying spinal cord and reducing Chiari II malformation.Spina was 16 fetuses from eight timed-pregnant at gestational age of 75 days. Two did not survive procedure. Repeat hysterotomy performed 95 days' gestation cover defect with either biocellulose film underwater adhesive (BCF-adhesive) (n = 7) or human umbilical suture (HUC-suture) 7). Three without...
Background: The use of alloplastic material in cranial reconstruction has been well described the adult population, especially when a paucity autologous tissue exists. In children it is unknown how long-term growth, however, may be affected by implantation nonexpansible material. Therefore, authors sought to compare outcomes pediatric patients undergoing versus reconstruction. Methods: To assess safety and cranioplasty children, an institutional review board-approved, retrospective, single...
The purpose of this study was to describe application and machine accuracy for a new computed tomography ( CT ) guided, frameless, stereotactic brain biopsy system in dogs. Heads from ten canine cadavers were secured bite‐plate with six attached fiducial markers imaged using . Fiducialized images imported into software spherical phantom lesions between 3.9 5.5 mm diameter created locations. Infrared cameras reflective used register fiducials the reconstructed image set. Coordinates X , Y Z...
Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barré (GBS), characterized by the triad ophthalmoplegia, ataxia, and areflexia, often following bacterial or viral illness. This case report presents 58-year-old Hispanic female patient with preceding streptococcal pharyngitis who developed symptoms bilateral facial nerve palsy lower limb ataxia. Cerebrospinal fluid (CSF) analysis revealed albuminocytologic dissociation and, combined her presentation supported diagnosis MFS. Magnetic...
Intracranial penetration during attempted nasogastric intubation is a rare, usually lethal, but avoidable complication. Such incidents are associated with facial and basilar skull fractures, acute neurologic deterioration, litigation. We report two such the successful surgical procedure which utilized craniotomies positioned that tubing could be removed in small, straight segments. The each case was without increasing deficit, patients made an acceptable recovery considering their premorbid status.
BACKGROUND: There is an urgent need for a regenerative patch in utero repair of spina bifida situations which primary closure difficult. CASES: We present two cases large myeloschisis defects that underwent at midgestation with the skin defect by using cryopreserved human umbilical cord patch. The pregnancies were uncomplicated, and births occurred 37 weeks planned cesarean delivery. sites intact no evidence cerebrospinal fluid leakage, regenerated after delivery over period 3–4 weeks....
Background: Both open cranial vault remodeling (CVR) and endoscopic suturectomy are effective in treating the anatomical deformity of craniosynostosis. While parents increasingly knowledgeable about these 2 treatment options, information regarding perioperative outcomes remains qualitative. This makes preoperative counseling surgical choices difficult. The purpose this study was to evaluate patients with craniosynostosis who underwent traditional CVR versus suturectomy. Methods: Open...
The objective of our study was to test the hypothesis that in utero repair surgically created spina bifida a sheep model using cryopreserved human umbilical cord (HUC) patch improves neurological outcome.Spina with myelotomy timed pregnant ewes at gestational day (GD) 75. fetuses were randomly assigned unrepaired versus HUC and treated GD 95 then delivered 140. Neurological evaluation performed Texas Spinal Cord Injury Scale (TSCIS), bladder control ultrasound, hindbrain herniation.Three...
Fetoscopic closure of spina bifida using heated and humidified carbon dioxide gas (hhCO
Despite significant improvement in spinal cord function after utero spina bifida (SB) repair compared with traditional postnatal repair, over half of the children who undergo this procedure do not benefit completely. This lack has been attributed to closure methods defect, subsequent tethering at site. Hence, a regenerative patch or material antiinflammatory and anti-scarring properties may alleviate comorbidities improved outcomes. The authors' primary objective was therefore compare...
Prenatal spina bifida (SB) repair with a regenerative patch may improve neurological outcomes by decreasing inflammatory scarring.This study aims to compare cryopreserved human umbilical cord (HUC) and biocellulose film (BCF) patches sutured over SB lesions for regeneration of native cells response.Sprague-Dawley rats were gavaged retinoic acid (RA) on embryonic day 10 induce SB. Hysterotomy was performed 20 HUC or BCF the defect. Pups harvested 30 34 h later, hematoxylin eosin staining...
Fetal surgery for repair of open neural tube defect (ONTD) typically results in decreased need a ventriculoperitoneal shunt (VPS). Our objectives were to determine the trend ventricle size (VS) during pregnancy and whether VS change VS, as assessed by ultrasound, predictive VPS with ONTD.This was retrospective analysis prospectively collected data consecutive pregnancies ONTD, evaluated single center from January 2012 May 2018. Two groups identified: first consisted that underwent in-utero...