A5005179597- Food Quality and Safety Studies
- Glioma Diagnosis and Treatment
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Advanced Proteomics Techniques and Applications
- Microbial Metabolism and Applications
- Barrier Structure and Function Studies
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- Heme Oxygenase-1 and Carbon Monoxide
- Protein Hydrolysis and Bioactive Peptides
- CAR-T cell therapy research
- Healthcare and Environmental Waste Management
- Food Supply Chain Traceability
- Viral Infectious Diseases and Gene Expression in Insects
- Acute Myeloid Leukemia Research
- Proteins in Food Systems
- Virus-based gene therapy research
- Gout, Hyperuricemia, Uric Acid
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Infant Health and Development
- Advanced biosensing and bioanalysis techniques
The University of Texas MD Anderson Cancer Center
2024
Northeast Agricultural University
2020-2024
The University of Texas Health Science Center at Houston
2024
University of Manitoba
2021-2022
Abstract β‐Casein, an important protein found in bovine milk, has significant potential for application the food, pharmaceutical, and other related industries. This review first introduces composition, structure, functional properties of β‐casein. It then reviews techniques isolating Chemical enzymatic isolation methods result inactivity β‐casein components it is difficult to control production conditions, limiting utilization range products. Physical technology not only achieves high...
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients display global dysfunction impaired killing capacity, altered metabolism, an exhausted phenotype at single-cell transcriptomic proteomic levels. In this study, we identified that was mediated through cross-talk between NK blasts cell-cell contact. cell...
Xanthine oxidase (XOD) catalyses the oxidation of hypoxanthine and xanthine to uric acid, inhibition its activity has become main strategy reduce acid production. Honeysuckle (HON) which is rich in polyphenols potentially capacity inhibit XOD activity. However, it carries bitter astringent flavor as well many traditional Chinese medicines, along with that most HON exist bound form, exploitation application food limited. In this study, we investigated effects Lacticaseibacillus rhamnosus L08...
Milk, which contains β-lactoglobulin (β-Lg; a major allergenic protein), is the most common food allergen and one of earliest discovered. Human milk oligosaccharides (HMOs), especially 2′-fucosyllactose (2′-FL), have multiple effects as prebiotics, including improvements to immune regulation, gut health, cognition. In this study, we investigated HMOs on immunoregulation intestinal flora in β-Lg-induced allergy mouse model. supplementation reduced allergic symptoms, decreased serum IgE...
Malignant gliomas derive from brain glial cells and represent >75% of primary tumors. This includes anaplastic astrocytoma (grade III; AS), the most common fatal glioblastoma multiforme IV; GBM), oligodendroglioma (ODG). We have generated patient-derived AS, GBM, ODG cell models to study disease mechanisms test patient-centered therapeutic strategies. used an aptamer-based high-throughput SOMAscan® 1.3K assay determine proteomic profiles 1307 different analytes. proteomes AS GBM...
Abstract: Honeysuckle (HON) is rich in polyphenols with abundant potential functional properties. However, it carries the bitter and astringent flavor as well many traditional Chinese medicines, along that most of honeysuckle exist bound form, exploitation application food limited. In this study, we investigated effects Lactobacillus rhamnosus L08 fermentation on bioactive components, properties characteristics HON. The results showed xanthine oxidase (XOD) inhibitory activity was increased...
<h3>Background</h3> Natural killer (NK) cells are crucial for eliminating tumor and virally-infected by integrating signals from activating inhibitory receptors. While NK-cell therapy has shown success in treating leukemias lymphomas, its effectiveness against solid tumors remains limited due to tumor-mediated suppression. Oncolytic viruses, which selectively target kill while enhancing antitumor immunity, offer a promising approach overcoming this Our study aims elucidate the mechanisms...
Introduction Breast cancer is the second leading cause of brain metastasis. 30% patients suffering from Triple Negative Cancer (TNBC) develop metastasis which confers poor prognosis to breast patients. The mechanisms that facilitate are not fully understood. TNBC cells have high levels endoplasmic reticulum stress (ER stress) and show activation IRE1 pathway Unfolded Protein Response (UPR). We showed MDA-231/BR cells, metastatic subline MDA-MB-231, endogenous activity suggesting this UPR...